Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The insulin signaling system.

1994 • 1,733 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin.

1995 • 499 citations

Exercise induces recruitment of the “insulin-responsive glucose transporter”. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.

1990 • 475 citations

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

1996 • 469 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 358 citations

The Effects of Wortmannin on Rat Skeletal Muscle

1995 • 320 citations

Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle

1985 • 263 citations

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes*

1997 • 252 citations

Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells

1997 • 241 citations

Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

1997 • 217 citations

Identification and Characterization of an Exercise-sensitive Pool of Glucose Transporters in Skeletal Muscle

1995 • 198 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner

1997 • 169 citations

Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter

1995 • 166 citations

Regulation of glucose transport into skeletal muscle

1996 • 165 citations

Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway

1997 • 143 citations

Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

1997 • 138 citations

Phosphoinositide 3-Kinase Is Required for Insulin-Induced but Not for Growth Hormone- or Hyperosmolarity-Induced Glucose Uptake in 3T3-L1 Adipocytes

1997 • 119 citations

Acute exercise increases the number of plasma membrane glucose transporters in rat skeletal muscle

1988 • 113 citations

Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors

1994 • 97 citations

Effect of diffusion distance on measurement of rat skeletal muscle glucose transport in vitro

1991 • 81 citations

Regulation of Protein Kinase B in Rat Adipocytes by Insulin, Vanadate, and Peroxovanadate

1997 • 75 citations

Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism

1997 • 69 citations

Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter.

1995 • 60 citations

Treadmill Running Increases Phosphatidylinostol 3-Kinase Activity in Rat Skeletal Muscle

1997 • 58 citations

A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in Vivo

1997 • 48 citations