Failure at the Effector Phase: Immune Barriers at the Level of the Melanoma Tumor Microenvironment

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 • 1,136 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

T cell apoptosis by tryptophan catabolism

2002 • 960 citations

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 • 834 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens

1998 • 712 citations

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

2006 • 705 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

The BRAF–MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells

2006 • 647 citations

Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses

2007 • 571 citations

Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy

2004 • 571 citations

Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma

2005 • 462 citations

Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy

2007 • 425 citations

Immune resistance orchestrated by the tumor microenvironment

2006 • 422 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma

2006 • 412 citations

CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers

2005 • 407 citations

Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

2004 • 366 citations

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

2007 • 353 citations

Priming of naive T cells inside tumors leads to eradication of established tumors

2004 • 344 citations

The B7 Family and Cancer Therapy: Costimulation and Coinhibition

2007 • 326 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

Inability of a Fusion Protein of IL-2 and Diphtheria Toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to Eliminate Regulatory T Lymphocytes in Patients With Melanoma

2005 • 293 citations

B7-H1 pathway and its role in the evasion of tumor immunity

2003 • 272 citations

Bystander elimination of antigen loss variants in established tumors

2004 • 259 citations

T cell clonal anergy

1997 • 257 citations

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

2006 • 250 citations

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 • 247 citations

Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen

2005 • 243 citations

Increasing Tumor Antigen Expression Overcomes “Ignorance” to Solid Tumors via Crosspresentation by Bone Marrow-Derived Stromal Cells

2002 • 239 citations

Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.

2000 • 238 citations

Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

2006 • 234 citations

Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts.

2000 • 229 citations

Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

2002 • 214 citations

Immunization With Melan-A Peptide-Pulsed Peripheral Blood Mononuclear Cells Plus Recombinant Human Interleukin-12 Induces Clinical Activity and T-Cell Responses in Advanced Melanoma

2003 • 153 citations

Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide

2001 • 153 citations

New Generation Vaccine Induces Effective Melanoma-Specific CD8+ T Cells in the Circulation but Not in the Tumor Site

2006 • 151 citations

Tumor progression despite massive influx of activated CD8+ T cells in a patient with malignant melanoma ascites

2006 • 143 citations

Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma

2005 • 134 citations

Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects

2005 • 132 citations

Tumor iNOS predicts poor survival for stage III melanoma patients

2006 • 127 citations

Toll-like Receptors in Tumor Immunotherapy

2007 • 120 citations

Differential expression of inflammatory chemokines by Th1‐ and Th2‐cell promoting dendritic cells: A role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation

2005 • 115 citations

Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control

2006 • 114 citations

CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma: correlation with clinicopathological prognostic factors

2006 • 103 citations

Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma

2005 • 101 citations

Interleukin 10 (IL-10): an immunosuppressive factor and independent predictor in patients with metastatic renal cell carcinoma

1999 • 88 citations

Homeostatic Proliferation as an Isolated Variable Reverses CD8+ T Cell Anergy and Promotes Tumor Rejection

2006 • 86 citations

Inhibition of in vivo tumor growth by the beta chemokine, TCA3.

1994 • 83 citations

Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.

1997 • 61 citations

In situ expression of B7 and CD28 receptor families in human malignant melanoma: Relevance for T‐cell‐mediated anti‐tumor immunity

1995 • 57 citations

Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumor.

1997 • 49 citations

CXC Chemokine Ligand 12 (Stromal Cell-Derived Factor 1α) and CXCR4-Dependent Migration of CTLs toward Melanoma Cells in Organotypic Culture

2005 • 42 citations

Control of T lymphocyte signal transduction through clonal anergy

1996 • 40 citations

The Role of LIGHT in T Cell-Mediated Immunity

2004 • 38 citations

Metabolic Mechanisms of Tumor Resistance to T Cell Effector Function

2005 • 20 citations

Intratumoral Expression of Macrophage-Derived Chemokine Induces CD4+ T Cell-Independent Antitumor Immunity in Mice

2003 • 12 citations