Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Gel electrophoresis of proteins: A practical approach

1982 • 798 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

1995 • 533 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

1990 • 508 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Modern Analytical Ultracentrifugation

1994 • 294 citations

Solution structure of the tetrameric minimum transforming domain of p53

1994 • 260 citations

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1993 • 252 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

Direct Evidence for DNA Bending at the Lambda Replication Origin

1987 • 233 citations

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.

1992 • 230 citations

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1993 • 206 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

p53 tagged sites from human genomic DNA

1994 • 178 citations

DNA bending by Cro protein in specific and nonspecific complexes: implications for protein site recognition and specificity

1994 • 166 citations

Protein-induced bending and DNA cyclization.

1992 • 163 citations

Interaction of p53 with Its Consensus DNA-Binding Site

1995 • 146 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

The p53 tumor suppressor protein: meeting review.

1993 • 128 citations

Physiological Concentration of Magnesium Ions Induces a Strong Macroscopic Curvature in GGGCCC-containing DNA

1994 • 127 citations

p53 oligomerization and DNA looping are linked with transcriptional activation.

1994 • 127 citations

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.

1995 • 126 citations

Gel electrophoresis of nucleic acids: A practical approach

1991 • 92 citations

DNA curving and bending in protein–DNA recognition

1992 • 83 citations

Specific sequences from the carboxyl terminus of human p53 gene product form anti-parallel tetramers in solution.

1994 • 62 citations

DNA bending induced by Cro protein binding as demonstrated by gel electrophoresis.

1991 • 57 citations

Interaction of the DNA‐binding domain of Drosophila heat shock factor with its cognate DNA site: A thermodynamic analysis using analytical ultracentrifugation

1994 • 55 citations

Studies of DNA bending and flexibility using gel electrophoresis

1993 • 55 citations

Forms and functions of p53.

1994 • 37 citations

Structural and kinetic analysis of p53-DNA complexes and comparison of human and murine p53.

1995 • 14 citations

Giant leap for p53, small step for drug design

1995 • 11 citations