Mammary tumorigenesis and chemoprevention studies in carcinogen-treated rats

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

1992 • 1,647 citations

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

1988 • 1,533 citations

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 • 997 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Mammary Cancer Induced by a Single Feeding of Polynuclear Hydrocarbons, and its Suppression

1961 • 788 citations

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

1994 • 745 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Differentiation of the mammary gland and susceptibility to carcinogenesis

1982 • 629 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins.

1985 • 495 citations

Inhibition of carcinogenesis by minor dietary constituents.

1992 • 407 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model.

1987 • 355 citations

<italic>N</italic>-Nitrosomethylurea as Mammary Gland Carcinogen in Rats

1975 • 354 citations

Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites.

1991 • 267 citations

Comparative dose—response tumorigenicity studies of dibenzo[a,l]pyrene versus 7, 12-dimethylbenz[a]anthracene, benzo[a and two dibenzo[a,l]pyrene dihydrodiols in mouse skin and rat mammary gland

1991 • 247 citations

DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

1987 • 233 citations

Mechanisms of induction of enzymes that protect against chemical carcinogenesis

1989 • 226 citations

Limonene-induced regression of mammary carcinomas.

1992 • 210 citations

Environmental carcinogens that may be involved in human breast cancer etiology

1992 • 180 citations

Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene

1984 • 167 citations

Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations.

1994 • 153 citations

Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea.

1981 • 145 citations

The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil

1989 • 145 citations

Dose-responsive induction of mammary gland carcinomas by the intraperitoneal injection of 1-methyl-1-nitrosourea.

1991 • 142 citations

Selective Responsiveness of Human Breast Cancer Cells to Indole-3-carbinol, a Chemopreventive Agent

1994 • 136 citations

Pathogenesis of Mammary Carcinomas Induced in Rats by 7, 12-Dimethylbenz[a]anthracene2

1977 • 132 citations

Piroxicam and other cyclooxygenase inhibitors: Potential for cancer chemoprevention

1992 • 122 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.

1992 • 120 citations

Prevention of mammary carcinogenesis in rats by pregnancy: effect of full-term and interrupted pregnancy

1988 • 109 citations

Chemoprevention of <italic>N</italic>-Nitroso-<italic>N</italic>-methylurea-Induced Mammary Cancers by Pretreatment with 17<italic>β</italic>-Estradiol and Progesterone<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1985 • 109 citations

Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid.

1990 • 103 citations

Genetic control of resistance to chemically induced mammary adenocarcinogenesis in the rat.

1986 • 97 citations

Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

1994 • 90 citations

Enhanced inhibition of mammary carcinogenesis by combined treatment with N-(4-hydroxyphenyl)retinamide and ovariectomy.

1982 • 87 citations

Effect of human chlorionic gonadoropin on mammary gland differentiation and carcinogenesis

1990 • 72 citations

Inhibition of Benzo[<italic>a</italic>]pyrene-Induced Mammary Carcinogenesis by Retinyl Acetate<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 67 citations

Evaluation of chemopreventive agents against breast cancer and proposed strategies for future clinical intervention trials

1994 • 66 citations

Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague–Dawley rats

1994 • 66 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary tumors and DNA adducts by dietary selenite.

1991 • 64 citations

Influence of dosage schedule on the biological characteristics of N-nitrosomethylurea-induced rat mammary tumors.

1980 • 63 citations

N-methyl-N-nitrosourea-induced rat mammary tumors. Hormone responsiveness but lack of spontaneous metastasis.

1981 • 62 citations

A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary turmorigenesis in rats fed different amounts of essential fatty acid

1989 • 59 citations

Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-l-nitrosourea

1992 • 56 citations

Retinoid antagonism of estrogen-responsive transforming growth factor alpha and pS2 gene expression in breast carcinoma cells.

1992 • 53 citations

Mammary Carcinogenesis in Rats in Relation to Age at Time of <italic>N</italic>-Nitroso-<italic>N</italic>-methylurea Administration<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1983 • 50 citations

A Direct Mechanism of Mammary Carcinogenesis Induced by 7,12-Dimethylbenz[a]anthracene2

1974 • 45 citations

Suppression by pregnancy of chemically induced preneoplastic cells of the rat mammary gland.

1986 • 45 citations

Mammary Cancer Induction by 7,12-Dimethylbenz( a )anthracene: Relation to Age

1969 • 43 citations

Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis.

1992 • 42 citations

Effect of D,L-α-difluoromethylornithine on murine mammary carcinogenesis

1984 • 42 citations

The Respective Rôles of Heredity and Somatic Mutation in the Origin of Malignancy

1936 • 37 citations

Cancer chemoprevention by aliphatic selenocyanates: effect of chain length on inhibition of mammary tumors and DMBA adducts

1995 • 37 citations

Effects of the prostaglandin synthetase inhibitor indomethacin on tumorigenesis, tumor proliferation, cell kinetics, and receptor contents of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague-Dawley rats fed a high- or low-fat diet.

1991 • 36 citations

Progression of rat mammary development with age and its relationship to carcinogenesis by a chemical carcinogen

1983 • 35 citations

Hyperplastic Lesions in the Mammary Glands of Sprague-Dawley Rats After 7,12-Dimethylbenz[<italic>a</italic>]anthracene Treatment<xref ref-type="fn" rid="FN1">2</xref>

1967 • 35 citations

Tumor production in rats injected intravenously with oil emulsions containing 9,10-dimethyl-1,2-benzanthracene.

1951 • 34 citations

The histogenesis of mammary tumours induced in the rat by chemical carcinogens

1965 • 33 citations

DNA Adduct Formation by 7, 12-Dimethylbenz[<italic>a</italic>]anthracene and Its Noncarcinogenic 2-Fluoro Analogue in Female Sprague-Dawley Rats<xref ref-type="fn" rid="FN2">2</xref>

1983 • 33 citations

Squamous cell differentiation markers in normal, premalignant, and malignant epithelium: Effects of retinoids

1993 • 32 citations

Site of origin of mammary tumors induced by 7,12-dimethylbenz(a)anthracene in the rat.

1975 • 30 citations

Mammary Tumor Formation Within Outgrowths of Transplanted Hyperplastic Nodules From Carcinogen-Treated Rats<xref ref-type="fn" rid="FN2">2</xref>

1968 • 29 citations

New Approaches to Cancer Chemoprevention With Difluoromethylornithine and Selenite

1989 • 20 citations

Cancer chemoprevention by retinoids: Animal models

1990 • 19 citations

DNA binding and adduct formation of 7,12-dimethylbenz[a]-anthracene by rat mammary epithelial cell aggregates in vitro

1986 • 19 citations

Estrogenic Mammary Cancer in the Rat

1939 • 18 citations

The effect of age on the histopathogenesis of 7,12‐dimethylbenz(a)‐anthracene‐induced mammary tumors in the lewis rat

1980 • 18 citations

Boundaries in Mammary Carcinogenesis

1991 • 9 citations

Tumours in the mammary gland induced in Lewis rats by intravenous methylnitrosurea

1975 • 9 citations

Effects of Ovariectomy on Preneoplastic Nodule Formation and Maintenance in the Mammary Glands of Carcinogen-Treated Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 8 citations