Three-dimensional structure of a highly thermostable enzyme, 3-isopropylmalate dehydrogenase of Thermus thermophilus at 2.2 Å resolution

A semi-empirical method of absorption correction

1968 • 7,409 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Electrostatic Effects in Proteins

1978 • 734 citations

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

1990 • 727 citations

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

1965 • 715 citations

Imaging plate illuminates many fields

1988 • 495 citations

Interaction of pyrophosphate moieties with .alpha.-helixes in dinucleotide-binding proteins

1985 • 475 citations

Disulfide Bond Engineered into T4 Lysozyme: Stabilization of the Protein Toward Thermal Inactivation

1984 • 311 citations

Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme

1987 • 300 citations

Dependence of conformational stability on hydrophobicity of the amino acid residue in a series of variant proteins substituted at a unique position of tryptophan synthase alpha subunit.

1987 • 247 citations

Regulation of an Enzyme by Phosphorylation at the Active Site

1990 • 246 citations

Processing oscillation diffraction data for very large unit cells with an automatic convolution technique and profile fitting

1979 • 228 citations

Protein engineering of subtilisin BPN': enhanced stabilization through the introduction of two cysteines to form a disulfide bond

1987 • 224 citations

Structure and Conformation of Nucleic Acids and Protein-Nucleic Acid Interactions

1976 • 209 citations

High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus.

1984 • 207 citations

The crystal structure of myoglobin: Phase determination to a resolution of 2 Å by the method of isomorphous replacement

1961 • 207 citations

Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.

1989 • 205 citations

RIBBON: a stereo cartoon drawing program for proteins

1988 • 190 citations

Computing in crystallography

1981 • 159 citations

On the relative scaling of X-ray photographs

1965 • 154 citations

Processing and post-refinement of oscillation camera data

1979 • 139 citations

Cloning of 3-Isopropylmalate Dehydrogenase Gene of an Extreme Thermophile and Partial Purification of the Gene Product

1981 • 133 citations

Effect of a single amino acid substitution on stability of conformation of a protein

1977 • 127 citations

Heat Stability of a Tetrameric Enzyme, D-Glyceraldehyde-3-PhosphateDehydrogenase

1980 • 119 citations

Electrostatic and Steric Contributions to Regulation at the Active Site of Isocitrate Dehydrogenase

1990 • 118 citations

An alternative method of solving the layer scaling equations of Hamilton, Rollett and Sparks

1966 • 109 citations

Unpaired cysteine-54 interferes with the ability of an engineered disulfide to stabilize T4 lysozyme

1986 • 91 citations

Purification, Catalytic Properties, and Thermal Stability of Threo-Ds-3-Isopropylmalate Dehydrogenase Coded by leuB Gene from an Extreme Thermophile, Thermus thermophilus Strain HB81

1990 • 81 citations

Describing patterns of protein tertiary structure

1985 • 49 citations

The nucleotide sequence of 3-isopropylmalate dehydrogenase gene fromBacillus subtilis

1987 • 33 citations

DNA and amino-acid sequences of 3-isopropylmalate dehydrogenase of Bacillus coagulans. Comparison with the enzymes of Saccharomyces cerevisiae and Thermus thermophilus

1986 • 29 citations

The nucleotide sequence of 3-isopropylmalate dehydrogenase gene fromBacillus caldotenax

1987 • 22 citations

A storage phosphor detector (imaging plate) and its application to diffraction studies using synchrotron radiation

1988 • 21 citations

Crystallization and Preliminary X-Ray Data for 3-Isopropylmalate Dehydrogenase of Thermus thermophilus1

1988 • 6 citations

Crystallization and Preliminary X-Ray Studies of a Bacillus subtilis and Thermuts thermophilus HB8 Chimeric 3-Isopropylmalate Dehy drogenasel

1991 • 5 citations