Novel biochemical pathways in parasitic protozoa

GLUTATHIONE

1983 • 5,487 citations

Federation Proceedings

2009 • 3,950 citations

Bulletin of the World Health Organization

1955 • 3,648 citations

POLYAMINES

1984 • 2,996 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

The Journal of General Microbiology

1985 • 2,446 citations

Molecular biology of the cell

1983 • 1,007 citations

Biology of the Kinetoplastida

1978 • 691 citations

Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids

1985 • 668 citations

Biochemistry and Physiology of Protozoa

1979 • 603 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Localization of nine glycolytic enzymes in a microbody‐like organelle in Trypanosoma brucei: The glycosome

1977 • 581 citations

THE JOURNAL OF BIOLOGICAL CHEMISTRY.

1905 • 551 citations

Biochemistry of Plasmodium (malarial parasites)

1979 • 497 citations

Compartmentation of Carbohydrate Metabolism in Trypanosomes

1987 • 476 citations

Atomic Structure of Thymidylate Synthase: Target for Rational Drug Design

1987 • 329 citations

Biochemistry of Plasmodium (malarial parasites).

1979 • 323 citations

Energy Metabolism of Protozoa without Mitochondria

1988 • 312 citations

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases

1986 • 267 citations

The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase

1988 • 265 citations

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

1987 • 261 citations

Mr 26,000 antigen of Schistosoma japonicum recognized by resistant WEHI 129/J mice is a parasite glutathione S-transferase.

1986 • 254 citations

Purine and pyrimidine metabolism in the trypanosomatidae

1984 • 244 citations

Glycolytic enzymes of Trypanosoma brucei. Simultaneous purification, intraglycosomal concentrations and physical properties

1986 • 216 citations

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

1982 • 214 citations

Progress in Clinical and Biological Research

1983 • 206 citations

In vitro activities of and mechanisms of resistance to antifol antimalarial drugs

1985 • 199 citations

Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei.

1984 • 199 citations

Trypanothione is the primary target for arsenical drugs against African trypanosomes.

1989 • 196 citations

Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme

1987 • 195 citations

Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3′ sequences

1988 • 192 citations

Metabolism of Entamoeba histolytica Schaudinn, 1903

1985 • 191 citations

Entamoeba histolytica : a Eukaryote Without Glutathione Metabolism

1984 • 189 citations

Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity

1985 • 186 citations

Chemotherapy and drug resistance in malaria

1990 • 184 citations

Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition.

1987 • 181 citations

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.

1988 • 181 citations

Folic acid metabolism.

1967 • 179 citations

The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni.

1988 • 177 citations

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

1987 • 175 citations

Topogenesis of microbody enzymes: a sequence comparison of the genes for the glycosomal (microbody) and cytosolic phosphoglycerate kinases of Trypanosoma brucei.

1985 • 168 citations

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major.

1986 • 165 citations

Conversion of dihydroorotate to orotate in parasitic protozoa

1979 • 155 citations

Trypanosomiasis: An Approach to Chemotherapy by the Inhibition of Carbohydrate Catabolism

1976 • 151 citations

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa

1984 • 145 citations

Insights into Enzyme Function from Studies on Mutants of Dihydrofolate Reductase

1988 • 143 citations

Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.

1979 • 143 citations

Leishmaniasis: the current status and new strategies for control

1989 • 140 citations

Characterization of the gene for the microbody (glycosomal) triosephosphate isomerase of Trypanosoma brucei.

1986 • 135 citations

Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids

1985 • 134 citations

Purine phosphoribosyltransferases from Leishmania donovani.

1980 • 134 citations

Two tandemly linked identical genes code for the glycosomal glyceraldehyde-phosphate dehydrogenase in Trypanosoma brucei.

1986 • 130 citations

Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei

1984 • 126 citations

Carbohydrate Metabolism in African Trypanosomes, with Special Reference to the Glycosome

1986 • 122 citations

Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes

1986 • 121 citations

Folate metabolism in malaria.

1977 • 120 citations

The enzymes of the glycolytic pathway in erythrocytes infected with Plasmodium falciparum malaria parasites

1988 • 118 citations

Parasite enzymes as potential targets for antiparasitic chemotherapy

1984 • 117 citations

Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo

1980 • 113 citations

Inhibition of pyrimidine biosynthesis de novo in Plasmodium falciparum by 2-(4-t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone in vitro

1985 • 111 citations

Structure and regulated expression of genes encoding fructose biphosphate aldolase in Trypanosoma brucei.

1985 • 110 citations

Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae

1983 • 107 citations

Common elements on the surface of glycolytic enzymes from Trypanosoma brucei may serve as topogenic signals for import into glycosomes.

1987 • 105 citations

Chemotherapy for Chagas' Disease: A Perspective of Current Therapy and Considerations for Future Research

1986 • 104 citations

Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei

1987 • 104 citations

Antitrypanosomal Effect of Allopurinol: Conversion in Vivo to Aminopyrazolopyrimidine Nucleotides by Trypanosoma cruzi

1978 • 104 citations

Biochemistry of Parasites

1973 • 104 citations

Subcellular Compartmentation of Glycolytic Intermediates in Trypanosoma brucei

1981 • 101 citations

New approach to screening drugs for activity against African trypanosomes

1977 • 101 citations

The topogenic signal of the glycosomal (microbody) phosphoglycerate kinase of Crithidia fasciculata resides in a carboxy-terminal extension.

1988 • 98 citations

Immunization with a Plasmodium falciparum merozoite surface antigen induces a partial immunity in monkeys.

1985 • 96 citations

Levels of Polyamines, Glutathione and Glutathione-Spermidine Conjugates during Growth of the Insect Trypanosomatid Crithidia fasciculata

1988 • 96 citations

Parasitic Protozoa and Polyamines

1987 • 95 citations

Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

1987 • 93 citations

The potential use of inhibitors of glycerol‐3‐phosphate oxidase for chemotherapy of African trypanosomiasis

1976 • 92 citations

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins.

1986 • 92 citations

Phosphorylation and anti-leishmanial activity of formycin B

1981 • 92 citations

Free radical metabolism of antiparasitic agents.

1986 • 91 citations

Stimulation of Trypanosoma brucei pyruvate kinase by fructose 2,6‐bisphosphate

1985 • 90 citations

Polyamine Depletion Following Exposure to DL‐α‐Difluoromethylornithine Both In Vivo and In Vitro Initiates Morphological Alterations and Mitochondrial Activation in a Monomorphic Strain of Trypanosoma brucei brucei

1986 • 89 citations

Free-Radical Intermediates in the Antiparasitic Action of Drugs and Phagocytic Cells

1984 • 86 citations

Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase

1988 • 84 citations

Aldolase Activity of a Plasmodium falciparum Protein with Protective Properties

1988 • 83 citations

The phosphoglycerate kinases from Trypanosoma brucei

1987 • 82 citations

Purine metabolism in Trichomonas vaginalis

1982 • 79 citations

In vivo time course of synthesis and processing of major schizont membrane polypeptides in Plasmodium falciparum

1986 • 75 citations

The Biochemistry and Functional Morphology of the Entamoeba1

1985 • 75 citations

Dihydrolipoamide dehydrogenase from Trypanosoma brucei. Characterization and cellular location

1987 • 72 citations

Proteins Responsible for a Punctate Fluorescence Pattern in Plasmodium Falciparum Merozoites

1984 • 72 citations

Glycosomes may provide clues to the import of peroxisomal proteins

1988 • 72 citations

Inhibition of Growth of Giardia lamblia by Difluoromethylornithine, a Specific Inhibitor of Polyamine Biosynthesis1

1984 • 71 citations

Mitochondrial DNA of the human malarial parasite Plasmodium falciparum

1988 • 70 citations

De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparum

1989 • 70 citations

A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and Leishmania

1981 • 67 citations

UMP synthesis in the kinetoplastida

1982 • 66 citations

Purine and pyrimidine metabolizing activities in Trichomonas vaginalis extracts

1983 • 64 citations

The pathway of arginine catabolism in the parasitic flagellate Trichomonas vaginalis

1983 • 63 citations

Entamoeba histolytica: I. Aerobic metabolism

1974 • 63 citations

Metabolism and mechanism of action of formycin B in Leishmania.

1983 • 63 citations

Biogenesis of the glycosome in Trypanosoma brucei: the synthesis, translocation and turnover of glycosomal polypeptides.

1987 • 62 citations

The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata

1986 • 61 citations

Biochemical changes associated with α-difluoromethylornithine uptake and resistance in Trypanosoma brucei

1987 • 61 citations

Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6‐bisphosphate and of glycolytic intermediates in Trypanosoma brucei

1987 • 61 citations

Mechanisms of sulfadoxine resistance in Plasmodium falciparum

1986 • 61 citations

Nucleotide sequence analysis of an Entamoeba histolytica ferredoxin gene

1988 • 61 citations

Fine Structure and Cytochemistry of the Hydrogenosome of Tritrichomonas foetus¹

1983 • 60 citations

The role of compartmentation and glycerol kinase in the synthesis of ATP within the glycosome of Trypanosoma brucei.

1985 • 59 citations

Cross-linking of the enzymes in the glycosome of Trypanosoma brucei.

1985 • 59 citations

Properties and substrate specificity of a purine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum

1988 • 58 citations

Glycerol, a metabolic end product of Trichomonas vaginalis and Tritrichomonas foetus

1986 • 55 citations

The purification and properties of two soluble reduced nicotinamide: acceptor oxidoreductases from Trichomonas vaginalis

1988 • 53 citations

Trypanosomatid hydrogen peroxidase metabolism

1987 • 53 citations

In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes

1987 • 52 citations

Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells.

1987 • 50 citations

Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei

1988 • 49 citations

Pyrimidine metabolism in Tritrichomonas foetus.

1983 • 48 citations

Products of Leishmania braziliensis glucose catabolism: release of D-lactate and, under anaerobic conditions, glycerol.

1987 • 47 citations

Characterisation of cDNA clones for hypoxanthine–guanine phosphoribosyltransferase from the human malarial parasite,Plasmodium falciparum: comparisons to the mammalian gene and protein

1987 • 47 citations

Antileishmanial action of 4-thiopyrazolo (3,4-d)pyrimidine and its ribonucleoside

1982 • 46 citations

Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei

1983 • 46 citations

Studies on glycerol kinase and its role in ATP synthesis in Trypanosoma brucei

1980 • 45 citations

d-lactate production by Leishmania braziliensis through the glyoxalase pathway

1988 • 44 citations

Purification and properties of NADPH:flavin oxidoreductase from Entamoeba histolytica

1980 • 44 citations

More molecular opportunism

1988 • 43 citations

Trypanosoma brucei: Preparation and some properties of a multienzyme complex catalysing part of the glycolytic pathway

1980 • 42 citations

A Freeze-Fracture Electron Microscope Study ofTrichomonas vaginalisDonné andTritrichomonas foetus(Riedmüller)¹

1984 • 42 citations

The metabolism of Plasmodium berghei, the malaria parasite of rodents. I. The preparation of the erythrocytic form of P. berghei separated from the host cell

1960 • 42 citations

¹³C‐NMR reveals glycerol as an unexpected major metabolite of the protozoan parasite Trichomonas vaginalis

1985 • 41 citations

Effect of dl-α-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium

1988 • 40 citations

Trypanothione metabolism: a chemotherapeutic target in trypanosomatids

1987 • 39 citations

The interactionin vitrobetween bovine immunoglobulin and juvenileFasciola hepatica

1981 • 38 citations

<scp>dl</scp>-α-difluoromethyl[3,4-3H]arginine metabolism in tobacco and mammalian cells. Inhibition of ornithine decarboxylase activity after arginase-mediated hydrolysis of <scp>dl</scp>-α-difluoromethylarginine to <scp>dl</scp>-α-difluoromethylornithine

1988 • 37 citations

Esters of 3,4-dihydroxybenzoic acid, highly effective inhibitors of the sn-glycerol-3-phosphate oxidase of Trypanosoma brucei brucei

1986 • 37 citations

End products of carbohydrate metabolism in Trichomonas vaginalis

1980 • 36 citations

p-alkyloxybenzhydroxamic acids, effective inhibitors of the trypanosome glycerol-3-phosphate oxidase

1986 • 35 citations

A comparative study of d-lactate, l-lactate and glycerol formation by four species of Leishmania and by Trypanosoma lewisi and Trypanosoma brucei gambiense

1988 • 32 citations

Polyamine Metabolism in Acanthamoeba: Polyamine Content and Synthesis of Ornithine, Putrescine, and Diaminopropane1

1987 • 30 citations

Entamoeba histolytica: Isolation of ferredoxin

1980 • 29 citations

Properties of the purine phosphoribosyltransferases ofTrypanosoma cruzi

1982 • 27 citations

Purine metabolism during continuous erythrocyte culture of human malaria parasites (P. falciparum).

1981 • 27 citations

Alternate metabolic pathways in protozoan energy metabolism.

1981 • 26 citations

The action of trypanocidal arsenical drugs on Trypanosoma brucei and Trypanosoma rhodesiense

1974 • 25 citations

Plasmodium berghei: Glycolytic enzymes of the infected mouse erythrocyte

1981 • 22 citations

Annual Review of Microbiology.

1985 • 22 citations

Effects of α-difluoromethylornithine on protein synthesis and synthesis of the variant-specific glycoprotein (VSG) in Trypanosoma brucei brucei

1988 • 21 citations

Tricarboxylic acid and glyoxylate cycles in the Leishmaniae.

1977 • 20 citations

Occurrence and role of phosphoenolpyruvate carboxykinase in procyclic Trypanosoma brucei brucei glycosomes

1983 • 20 citations

Purification and Properties of NADP-Linked, Alcohol Dehydrogenase from Entamoeba histolytica

1982 • 19 citations

Chemotherapy of trypanosomiasis: the potentiation of melarsoprol by concurrent difluoromethylornithine (DFMO) treatment

1988 • 19 citations

Identification of two integral glycosomal membrane proteins in Trypanosoma brucei

1987 • 19 citations

Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids

1987 • 18 citations

Polyamines in Acanthamoeba castellanii: Presence of an unusually high, osmotically sensitive pool of 1,3-diaminopropane

1984 • 18 citations

Subcellular localisation of purinemetabolising enzymes in Leishmania mexicana mexicana

1985 • 17 citations

The role of threonine in the metabolism of acetyl coenzyme A by Trypanosoma brucei brucei

1983 • 16 citations

Plasmodium berghei: Glycolytic intermediate concentrations of the infected mouse erythrocyte

1981 • 16 citations

Purification and properties of a secondary alcohol dehydrogenase from the parasitic protozoan Tritrichomonas foetus.

1985 • 15 citations

Studies on the glycosomal orotate phosphoribosyl transferase of Trypanosoma cruzi

1983 • 15 citations

THE GLYCOSOME

1982 • 13 citations

Absence of substrate channeling in the glycosome of Trypanosoma brucei

1986 • 7 citations