Chemotherapy for Chagas' Disease: A Perspective of Current Therapy and Considerations for Future Research

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Taxol stabilizes microtubules in mouse fibroblast cells.

1980 • 1,942 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

Localization of nine glycolytic enzymes in a microbody‐like organelle in Trypanosoma brucei: The glycosome

1977 • 581 citations

The Role of Free Radical Reactions in Biological Systems

1976 • 374 citations

The Molecular Biology of Trypanosomes

1982 • 249 citations

Free-Radical Intermediates in the Metabolism of Toxic Chemicals

1982 • 197 citations

The Kinetoplast of the Hernoflagellates

1972 • 190 citations

Oxygen inhibition of nitroreductase: Electron transfer from nitro radical-anions to oxygen

1976 • 184 citations

Free Radical Metabolites in the Mode of Action of Chemotherapeutic Agents and Phagocytic Cells on Trypanosoma cruzi

1984 • 173 citations

Conversion of dihydroorotate to orotate in parasitic protozoa

1979 • 155 citations

Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

1979 • 136 citations

Present status of chemotheraphy and chemoprophylaxis of human trypanosomiasis in the Western Hemisphere

1979 • 122 citations

Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis.

1985 • 119 citations

Free minicircles of kinetoplast DNA in Crithidia fasciculata.

1979 • 118 citations

In vitroandin vivoevaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives againstTrypanosoma cruzi

1978 • 109 citations

Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae

1983 • 107 citations

Chemotherapeutic Properties of Heterocyclic Compounds: Monocyclic Compounds with Five-Membered Rings

1973 • 105 citations

Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations

1982 • 105 citations

Toxicity of Nitro Compounds Toward Hypoxic Mammalian Cells In Vitro: Dependence on Reduction Potential

1980 • 104 citations

Antitrypanosomal Effect of Allopurinol: Conversion in Vivo to Aminopyrazolopyrimidine Nucleotides by Trypanosoma cruzi

1978 • 104 citations

Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus.

1983 • 98 citations

The potential use of inhibitors of glycerol‐3‐phosphate oxidase for chemotherapy of African trypanosomiasis

1976 • 92 citations

A re-examination of purine and pyrimidine synthesis in the three main forms of Trypanosoma cruzi

1979 • 91 citations

Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in β-lapachone-treated Trypanosoma cruzi epimastigotes

1978 • 86 citations

Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi

1981 • 84 citations

Purine metabolism in Trypanosoma cruzi

1981 • 83 citations

Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes.

1984 • 79 citations

Subcellular localization of some glycolytic enzymes in parasitic flagellated protozoa

1980 • 77 citations

Biological action of inosine analogs in Leishmania and Trypanosoma spp

1984 • 73 citations

Trypanosoma cruzi: Allopurinol in the treatment of mice with experimental acute Chagas disease

1981 • 68 citations

The enzymes of pyrimidine biosynthesis in a range of parasitic protozoa and helminths

1981 • 67 citations

A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and Leishmania

1981 • 67 citations

UMP synthesis in the kinetoplastida

1982 • 66 citations

Nitroimidazoles as anaerobic electron acceptors for xanthine oxidase

1982 • 65 citations

A NEW ANTIBIOTIC, FORMYCIN.

1964 • 59 citations

Cross-linking of the enzymes in the glycosome of Trypanosoma brucei.

1985 • 59 citations

Reduction of nitroimidazole derivatives by hydrogenosomal extracts of Trichomonas vaginalis

1985 • 54 citations

Replication of the kinetoplast DNA of Leishmania tarentolae and Crithidia fasciculata

1974 • 54 citations

Recent developments in the field of Chagas' disease.

1982 • 53 citations

On the Fine Structure of the Nucleus in Trypanosoma cruzi in Tissue Culture Forms. Spindle Fibers in the Dividing Nucleus*

1974 • 51 citations

Subcellular localization of phosphoenolpyruvate carboxykinase in the trypanosomatids Trypanosoma cruzi and Crithidia fasciculata

1982 • 50 citations

Effect of Allopurinol on Different Strains of Trypanosoma Cruzi

1981 • 49 citations

Multiple-dose kinetics of the trypanosomicide benznidazole in man.

1980 • 49 citations

Evaluation of the toxicity of 3-allyl-β-lapachone against Trypanosma cruzi bloodstream forms

1980 • 47 citations

Maxi-circles and mini-circles in kinetoplast DNA from Trypanosoma cruzi

1980 • 46 citations

Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei

1983 • 46 citations

Effect of allopurinol on Trypanosoma cruzi: metabolism and biological activity in intracellular and bloodstream forms

1982 • 46 citations

Adenylosuccinate synthetase and adenylosuccinate lyase from trypanosoma cruzi

1982 • 45 citations

Studies on glycerol kinase and its role in ATP synthesis in Trypanosoma brucei

1980 • 45 citations

9-Deazaadenosine—A new potent antitumor agent

1984 • 40 citations

Metronidazole Inhibition of Hydrogen Production in vivo in Drug-sensitive and Resistant Strains of Trichomonas vaginalis

1985 • 39 citations

Chemotherapy of experimental Chagas' disease with nitrofuran compounds.

1957 • 39 citations

Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi

1978 • 39 citations

Kinetoplast DNA minicircles of trypanosomatids encode for a protein product

1984 • 39 citations

STEREOCHEMICAL ANALYSIS OF THE SPECIFICITY OF PANCREATIC RNASE WITH POLYFORMYCIN AS SUBSTRATE: DIFFERENTIATION OF THE TRANSPHOSPHORYLATION AND HYDROLYSIS REACTIONS

1969 • 39 citations

Inhibition of lymphocyte function by 9-deazaadenosine

1983 • 39 citations

Enzymes of purine salvage in Trypanosoma cruzi

1981 • 38 citations

Purine Metabolism in Trypanosomatids*

1979 • 35 citations

Drug metabolism and chemosensitization

1983 • 30 citations

Quantitative determination of nifurtimox in body fluids of rat, dog and man.

1972 • 28 citations

No detectable reaction of the anion radical metabolite of nitrofurans with reduced glutathione or macromolecules

1984 • 28 citations

Treatment of urinary tract infections with a new antibacterial nitrofuran.

1953 • 28 citations

The metabolism and cytotoxic effects of formycin B in Trypanosoma cruzi

1983 • 27 citations

Properties of the purine phosphoribosyltransferases ofTrypanosoma cruzi

1982 • 27 citations

Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages ofTrypanosoma cruzi

1978 • 27 citations

Differences in allopurinol and 4-aminopyrazolo(3,4-d) pyrimidine metabolism in drug-sensitive and insensitive strains of Trypanosoma cruzi

1984 • 22 citations

Efficacy of Pyrazolopyrimidine Ribonucleosides Against Irypanosoma cruzi: Studies in Vitro and in Vivo with Sensitive and Resistant Strains

1984 • 22 citations

Studies on Experimental Chagas' Disease in Mice in Relation to Chemotherapeutic Testing

1951 • 21 citations

Effects of nitroheterocyclic drugs on macromolecule synthesis and degradation in Trypanosoma cruzi

1985 • 19 citations

Enzymes of pyrimidine biosynthesis in Trypanosoma cruzi

1980 • 19 citations

9-Deazaadenosine. Cytocidal activity and effects on nucleic acids and protein synthesis in human colon carcinoma cells in culture.

1983 • 18 citations

The Replication of Kinetoplast DNA

1980 • 17 citations

FREE RADICAL INTERMEDIATES IN THE TRYPANOCIDAL ACTION OF DRUGS AND PHAGOCYTIC CELLS

1984 • 16 citations

Nucleotide and polynucleotide synthesis in Trypanosoma cruzi. VII. Precursors of the pyrimidine nucleotides

1962 • 15 citations

Studies on the glycosomal orotate phosphoribosyl transferase of Trypanosoma cruzi

1983 • 15 citations

Effect of benznidazole on the mixed function oxygenase system from rat liver microsomes.

1985 • 11 citations

Aspects of pyrimidine biosynthesis of Trypanosoma cruzi.

1974 • 7 citations