Comparison of the metabolism of the three antidepressants amitriptyline, imipramine, and chlorimipramine in vitro in rat liver microsomes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVER

1962 • 718 citations

SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).

1964 • 234 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression

1979 • 142 citations

Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline

1979 • 106 citations

Human cytochromes P-450

1984 • 99 citations

Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat

1982 • 94 citations

Active metabolites of imipramine and desipramine in man

1982 • 89 citations

The metabolism of imipramine and its metabolites by rat liver microsomes

1966 • 77 citations

Hydroxylated metabolites of tricyclic antidepressants: preclinical assessment of activity.

1979 • 74 citations

Inhibition of biogenic amines uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain

1979 • 66 citations

Desipramine hydroxylation: Variability and effect of antipsychotic drugs

1983 • 50 citations

Neuropharmacological Properties of Amitriptyline, Nortriptyline and their Metabolites

1980 • 49 citations

Imipramine metabolites in blood of patients during therapy and after overdose

1983 • 46 citations

Liver metabolic reactions: Tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation

1972 • 45 citations

Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels

1982 • 45 citations

Sex-dependent differences in drug metabolism in the rat. IV. Effect of morphine administration.

1974 • 40 citations

Evidence for Two Catalytically Different Binding Sites of Liver Microsomal Cytochrome P‐450: Importance for Species and Sex Differences in Oxidation Pattern of Lidocaine

1977 • 40 citations

Spectral Studies on the Interaction of Imipramine and some of its Oxidized Metabolites with Rat Liver Microsomes

1971 • 39 citations

Steady-state plasma concentrations of cis- and trans-10-OH amitriptyline metabolites

1982 • 39 citations

Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.

1981 • 39 citations

New metabolites of imipramine

1966 • 38 citations

The analysis and disposition of imipramine and its active metabolites in man

1984 • 35 citations

Relationship between the plasma concentration of clomipramine and desmethylclomipramine in depressive patients and the clinical response

1982 • 35 citations

Plasma steady-state concentrations of hydroxylated metabolites of clomipramine

1982 • 33 citations

Studies on the demethylation,hydroxylation and N-oxidation of imipramine in rat liver

1970 • 28 citations

Sex-dependent differences in drug metabolism in the rat. 3. Temporal changes in type I binding and NADPH-cytochrome, P-450 reductase during sexual maturation.

1974 • 25 citations

Metabolic Interconversions and Binding of Imipramine, Imipramine-N-Oxide, and Desmethylimipramine in Rat Liver Slices

1971 • 20 citations

Hydroxylation and Subsequent Glucuronide Conjugation of Desmethylimipramine in Rat Liver Microsomes

1971 • 20 citations

Binding and Oxidation of Amitriptyline and a Series of its Oxidized Metabolites in Liver Microsomes from Untreated and Phenobarbital-treated Rats

1972 • 20 citations

N-oxidation of imipramine by isolated perfused rat and rabbit lung

1980 • 20 citations

Vergleichende Demethylierung von tricyclischen Psychopharmaka durch Rattenleber-Mikrosomen

1967 • 18 citations

Intraindividual Similarity in the Metabolism of Amitriptyline and Chlorimipramine in Depressed Patients

1979 • 18 citations

Identification and evaluation of amitryptiline and its basic metabolites in rabbit's urine

1968 • 16 citations

Imipramine and chlorpromazine in hepatic microsomal systems.

1974 • 11 citations

[Comparative demethylation of tricyclic psychotropic drugs by rat liver microsomes].

1967 • 6 citations

MECHANISM OF N-OXIDE FORMATION BY HEPATIC MIXED FUNCTION OXIDASES

1977 • 5 citations

Metabolic oxidation of desmethylchlorimipraminein vitroby 9000grabbit-liver preparations

1982 • 4 citations

Phase I metabolism of imipramine by microsomes of small intestine in comparison with metabolism by liver microsomes

1983 • 3 citations