The analysis and disposition of imipramine and its active metabolites in man

Statistical moments in pharmacokinetics

1978 • 1,251 citations

Bioavailability -- A Problem in Equivalence

1974 • 620 citations

A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximation

1978 • 423 citations

Altered Hepatic Blood Flow and Drug Disposition1

1976 • 209 citations

Plasma protein binding of basic drugs. I. Selective displacement from alpha 1-acid glycoprotein by tris(2-butoxyethyl) phosphate.

1977 • 162 citations

First‐pass metabolism of imipramine in man

1975 • 121 citations

Plasma protein binding of basic drugs

1977 • 118 citations

Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil)

1961 • 113 citations

Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of the anesthetized dogs

1977 • 99 citations

Active metabolites of imipramine and desipramine in man

1982 • 89 citations

First‐pass metabolism of nortriptyline in man

1975 • 78 citations

Hydroxylated metabolites of tricyclic antidepressants: preclinical assessment of activity.

1979 • 74 citations

High‐Performance Liquid Chromatographic Assay for Imipramine, Desipramine, and Their 2‐Hydroxylated Metabolites

1979 • 72 citations

4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranolol

1980 • 70 citations

Plasma levels of imipramine and desipramine in man after different routes of administration

1975 • 63 citations

The demethylation of imipramine and clomipramine as apparent from their plasma kinetics

1977 • 59 citations

Preliminary pharmacological and clinical results with desmethylimipramine (DMI) G 35020, a metabolite of imipramine

1961 • 58 citations

Presystemic and systemic glucuronidation of propranolol

1979 • 57 citations

Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine.

1983 • 50 citations

Route of Administration and Drug Disposition

1975 • 50 citations

Desmethylimipramine, a New Type of Antidepressant Drug

1961 • 45 citations

Desipramine and 2-hydroxy-desipramine pharmacokinetics in normal volunteers

1981 • 37 citations

Comparison of single dose kinetics of imipramine, nortriptyline and antipyrine in man

1976 • 33 citations

Dose-dependent kinetics of imipramine in elderly patients

1981 • 33 citations

Plasma Concentration Monitoring of Hydroxylated Metabolites of Imipramine and Desipramine

1981 • 22 citations

CLOZAPINE-LIKE DRUGS

1980 • 20 citations

The effect of various phenothiazines and tricyclic antidepressants on the accumulation and release of (3H)norepinephrine and (3H)5-hydroxytryptamine in slices of rat occipital cortex.

1976 • 16 citations

The clinical impact of blood collection methods on tricyclic antidepressants as measured by GC/MS-SIM.

1978 • 13 citations