Binding and Oxidation of Amitriptyline and a Series of its Oxidized Metabolites in Liver Microsomes from Untreated and Phenobarbital-treated Rats

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVER

1962 • 718 citations

Ligand interactions with cytochrome P-450. I. Binding of primary amines

1969 • 227 citations

Cytochrome P-450 of liver microsomes—One pigment or many

1968 • 224 citations

Inhibition of the TPNH-linked lipid peroxidation of liver microsomes by drugs undergoing oxidative demethylation

1964 • 191 citations

Substrate interaction with hydroxylase system in liver microsomes

1966 • 183 citations

Relationship between the lipid solubility of drugs and their oxidation by liver microsomes

1959 • 152 citations

A specific gas-chromatographic method for the measurement of “steady-state” plasma levels of amitriptyline and nortriptyline in patients

1971 • 125 citations

Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry

1972 • 107 citations

A gas chromatographic method for the quantitative determination of nortriptyline and some of its metabolites in human plasma and urine

1972 • 82 citations

A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase

1972 • 66 citations

Novel peak matching technique by means of a new and combined multiple ion detector-peak matcher device. Elemental analyses of compounds in submicrogram quantities without prior isolation

1971 • 65 citations

Domethylation Studies--I., The Effect of Chemical Structure and Lipis Solubility

1961 • 62 citations

Gas chromatography‐mass spectrometry of nortriptyline in body fluids of man

1971 • 56 citations

History and Scope

1962 • 48 citations

Concentrations of Amitriptyline and its Metabolites in Urine, Blood and Tissue in Fatal Amitriptyline Poisoning

1969 • 39 citations

Spectral Studies on the Interaction of Imipramine and some of its Oxidized Metabolites with Rat Liver Microsomes

1971 • 39 citations

The Role of Cytochrome P-450 in Microsomal Mixed Function Oxidation Reactions

1968 • 36 citations

Species of cytochrome P-450 in rat liver microsomes with different stereoselectivity for the binding and monooxygenation of (+)- and (?)-methylphenobarbital

1971 • 25 citations

Effect of Phenobarbital and_3,4-Benzpyrene Treatment of Rats on the Microsomal Binding and Hydroxylation of Nortriptyline and Desmethyl-imipramine: Evidence for Qualitative Changes in Cytochrome P-450-Ligand Interaction following Phenobarbital Pretreatment

1972 • 22 citations

Excretion of Nortriptyline Hydrochloride in Man I

1966 • 18 citations

THE MICROSOMAL HYDROXYLATION OF ETHYLBENZENE STEREOCHEMICAL, INDUCTION AND ISOTOPIC STUDIES

1969 • 8 citations