Predominance of the metastatic phenotype in hybrids formed by fusion of mouse and human melanoma clones

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With <sup>125</sup>I-5-Iodo-2′ -deoxyuridine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1970 • 990 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Antioncogenes and human cancer.

1993 • 772 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes.

1967 • 517 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 355 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.

1981 • 291 citations

Gene amplification in cultured cells.

1988 • 289 citations

Speculations on the Role of Ultraviolet Radiation in the Development of Malignant Melanoma4

1979 • 228 citations

Cancer invasion and metastasis : biologic and therapeutic aspects

1984 • 221 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 213 citations

DNA Strand Breaks: the DNA Template Alterations That Trigger p53-Dependent DNA Damage Response Pathways

1994 • 198 citations

Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.

1981 • 195 citations

Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells.

1994 • 195 citations

Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells.

1991 • 192 citations

Growth Dominance of the Metastatic Cancer Cell: Cellular and Molecular Aspects

1990 • 179 citations

Expression of mutant p53 in melanoma.

1991 • 170 citations

High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors: evidence for strand bias and tumor heterogeneity.

1993 • 164 citations

Somatic allelic deletion of nm23 in human cancer.

1991 • 159 citations

Tumor invasion and metastasis.

1986 • 156 citations

Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity.

1994 • 139 citations

Correlation of Growth Capacity of Human Tumor Cells in Hard Agarose With Their In Vivo Proliferative Capacity at Specific Metastatic Sites

1989 • 135 citations

Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11.

1992 • 130 citations

Cell adhesion receptor expression during melanoma progression and metastasis

1991 • 125 citations

Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate-mediated DNA transfection.

1987 • 120 citations

Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements.

1986 • 116 citations

Overexpression of p53 is a late event in the development of malignant melanoma.

1993 • 115 citations

p53 Mutations: Gains or losses?

1991 • 111 citations

Chromosome banding techniques.

1976 • 106 citations

Clonal dominance of primary tumours by metastatic cells: genetic analysis and biological implications.

1988 • 105 citations

Molecular mechanisms of cancer metastasis

1991 • 103 citations

Mutation and expression of the p53 gene in malignant melanoma cell lines

1993 • 90 citations

Location of genes involved in invasion and metastasis on human chromosome 7.

1987 • 85 citations

Mutational Analysis of the Human p53 Gene in Malignant Melanoma

1991 • 84 citations

Differential suppression of mammary and prostate cancer metastasis by human chromosomes 17 and 11.

1994 • 83 citations

Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8.

1994 • 79 citations

p53 immunoreactivity in human malignant melanoma and dysplastic naevi

1993 • 74 citations

Physical mapping of human chromosome 17 using fragment-containing microcell hybrids

1989 • 66 citations

Expression of p53 protein in cutaneous melanoma

1992 • 64 citations

p53 Protein Expression in Nevi and Melanomas

1993 • 59 citations

Different Deficiencies in the Prevention of Tumorigenic-Low-Metastatic Murine K-1735b Melanoma Cells From Producing Metastases<xref ref-type="fn" rid="FN2">2</xref>

1986 • 54 citations

p53 Protein Detected By Immunohistochemical Staining is Not Always Mutant

1993 • 51 citations

The Ernst W. Bertner Memorial Award lecture: the evolution of biological heterogeneity in metastatic neoplasms.

1983 • 49 citations

Metastatic inefficiency

1982 • 39 citations

Expression level of the nm23 gene in clonal populations of metastatic murine and human neoplasms.

1992 • 38 citations

Predominance of the metastatic phenotype in somatic cell hybrids of the K-1735 murine melanoma.

1991 • 23 citations

Transfection of activated c-H-rasEJ/pSV2neo or pSV2neo genes into rat mammary cells: rapid stimulation of clonal diversification of spontaneous metastatic and cell-surface properties.

1992 • 19 citations

P53 MUTATIONS ARE INFREQUENT AND DO NOT CORRELATE WITH THE METASTATIC POTENTIAL OF HUMAN-MELANOMA CELLS

1993 • 9 citations

Evidence for human DNA-mediated transfer of the suppressed phenotype into malignant Chinese hamster cells.

1991 • 6 citations

Genetic aspects of tumour metastasis.

1988 • 5 citations

Suppression of tumorigenicity in T-cell lymphoma hybrids is correlated with changes in myc expression and DNA replication of the myc chromosomal domain

1988 • 5 citations

Metastatic phenotype in hybrid cells derived from B16 melanoma

1994 • 3 citations

Suppression of malignancy in human lymphoid cell hybrids: The role of differentiation

1989 • 2 citations