Overexpression of p53 is a late event in the development of malignant melanoma.

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma

1984 • 963 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

1991 • 512 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland

1992 • 350 citations

The developmental biology of primary human malignant melanomas.

1975 • 336 citations

Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue.

1992 • 257 citations

Expression of p53 in premalignant and malignant squamous epithelium.

1991 • 237 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis.

1992 • 198 citations

Expression of mutant p53 in melanoma.

1991 • 170 citations

p53 Protein alterations in human testicular cancer including pre‐invasive intratubular germ‐cell neoplasia

1991 • 133 citations

Mutational Analysis of the Human p53 Gene in Malignant Melanoma

1991 • 84 citations