Neuroimaging correlates of HIV-associated BBB compromise

The AIDS Dementia Complex

1988 • 1,387 citations

HIV-associated neurologic disease incidence changes:

2001 • 597 citations

HIV-associated cognitive impairment before and after the advent of combination therapy

2002 • 585 citations

Cellular reservoirs of HIV-1 in the central nervous system of infected individuals

1996 • 412 citations

Neuropsychological Outcome of Zidovudine (AZT) Treatment of Patients with AIDS and AIDS-Related Complex

1988 • 395 citations

HIV Dementia Scale: A Rapid Screening Test

1995 • 374 citations

Transient Exposure to HIV-1 Tat Protein Results in Cytokine Production in Macrophages and Astrocytes

1999 • 351 citations

A Trojan Horse mechanism for the spread of visna virus in monocytes

1985 • 340 citations

Changes in pathological findings at autopsy in AIDS cases for the last 15 years

2000 • 327 citations

Reduced basal ganglia volume in HIV‐1‐associated dementia

1993 • 318 citations

Human Immunodeficiency Virus (HIV) Proteins in Neuropathogenesis of HIV Dementia

2002 • 318 citations

HIV antigen in the brains of patients with the AIDS dementia complex

1987 • 289 citations

Role of Mononuclear Phagocytes in the Pathogenesis of Human Immunodeficiency Virus Infection

1990 • 277 citations

Blood‐brain barrier abnormalities in acquired immunodeficiency syndrome: Immunohistochemical localization of serum proteins in postmortem brain

1992 • 275 citations

Human immunodeficiency virus-1 infection of the nervous system: An autopsy study of 268 adult, pediatric, and fetal brains

1991 • 269 citations

Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex

1999 • 238 citations

Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia

1999 • 231 citations

Apoptosis induced by HIV-1 infection of the central nervous system.

1996 • 230 citations

Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.

1993 • 224 citations

HIV-Related Neuropathology, 1985 to 1999: Rising Prevalence of HIV Encephalopathy in the Era of Highly Active Antiretroviral Therapy

2002 • 224 citations

TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.

1997 • 188 citations

The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α

1995 • 169 citations

Acceleration of HIV dementia with methamphetamine and cocaine

2001 • 168 citations

Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV patients

1999 • 167 citations

Patterns of cerebral atrophy in HIV–1–infected individuals

1992 • 164 citations

TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier

1997 • 163 citations

AIDS And the Nervous System

1988 • 157 citations

The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α

1995 • 150 citations

AIDS dementia complex: evaluation with proton MR spectroscopic imaging.

1995 • 147 citations

Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments.

2001 • 142 citations

Metabolite abnormalities in progressive rnultifocal leukoencephalopathy by proton magnetic resonance spectroscopy

1997 • 136 citations

HIV Dementia and the Basal Ganglia

1997 • 125 citations

Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia.

1996 • 125 citations

Cocaine opens the blood-brain barrier to HIV-1 invasion

1998 • 124 citations

Pathobiology of Human Immunodeficiency Virus Dementia

1999 • 117 citations

Regional brain atrophy in HIV-1 infection: association with specific neuropsychological test performance

2009 • 109 citations

HIV-1 Tat-Mediated Apoptosis in Human Brain Microvascular Endothelial Cells

2003 • 108 citations

Cerebrovascular changes in the basal ganglia with HIV dementia

2000 • 90 citations

Absolute Quantitation of Short TE Brain 1H-MR Spectra and Spectroscopic Imaging Data

1993 • 87 citations

HIV infection of human brain capillary endothelial cell — Implications for AIDS dementia

1994 • 86 citations

Potential Time Course of Human Immunodeficiency Virus Type 1–Associated Minor Motor Deficits

2000 • 83 citations

Clinical and spectroscopic improvement in HIV-associated cognitive impairment

2001 • 82 citations

Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

2004 • 80 citations

HIV-1 Tat Molecular Diversity and Induction of TNF-α: Implications for HIV-Induced Neurological Disease

1998 • 80 citations

Cerebral metabolic change in patients with AIDS: report of a six-month follow-up using positron-emission tomography

1995 • 79 citations

A randomized clinical trial of CPI-1189 for HIV-associated cognitive–motor impairment

2002 • 74 citations

Release of Calcium from Inositol 1,4,5-Trisphosphate Receptor-Regulated Stores by HIV-1 Tat Regulates TNF-α Production in Human Macrophages

2000 • 73 citations

Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1-infected individuals—correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels

2001 • 70 citations

The relationship between age and cognitive impairment in HIV‐1 infection

1994 • 65 citations

Increased cerebral blood volume in HIV‐positive patients detected by functional MRI

1998 • 65 citations

AIDS and the Nervous System

1997 • 65 citations

Understanding pathogenesis and treatment of HIV dementia: a role for magnetic resonance?

2002 • 58 citations

Metabolic characterization of AIDS dementia complex by spectroscopic imaging

1999 • 54 citations

Vascular changes in the cerebral cortex in HIV-1 infection

1996 • 47 citations

In Vivo Magnetic Resonance Spectroscopy in HIV and HIV-Related Brain Diseases

1995 • 44 citations

Frequency and topographical distribution of CD68-positive macrophages and HIV-1 core proteins in HIV-associated brain lesions.

1993 • 41 citations

Brain imaging in acquired immunodeficiency syndrome dementia complex

1990 • 40 citations

Intrathecal IgG synthesis and albumin leakage are increased in subjects with HIV-1 neurologic disease.

1994 • 37 citations

Neurocognitive Symptoms and Impairment in an HIV Community Clinic

2001 • 25 citations

Neuropsychological aspects of HIV infection

1992 • 24 citations

Electrophysiological motor testing, MRI findings and clinical course in AIDS patients with dementia

1993 • 22 citations