Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

The AIDS Dementia Complex

1988 • 1,387 citations

HIV-associated neurologic disease incidence changes:

2001 • 597 citations

HIV-associated cognitive impairment before and after the advent of combination therapy

2002 • 585 citations

Cytokine expression in the brain during the acquired immunodeficiency syndrome

1992 • 572 citations

Changes to AIDS dementia complex in the era of highly active antiretroviral therapy

1999 • 422 citations

Cellular reservoirs of HIV-1 in the central nervous system of infected individuals

1996 • 412 citations

Relationship between human immunodeficiency virus—associated dementia and viral load in cerebrospinal fluid and brain

1997 • 397 citations

Neuropsychological Outcome of Zidovudine (AZT) Treatment of Patients with AIDS and AIDS-Related Complex

1988 • 395 citations

HIV Dementia Scale: A Rapid Screening Test

1995 • 374 citations

Leukocyte traffic in the central nervous system: the participants and their roles

1999 • 348 citations

Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood‐brain barrier

1993 • 333 citations

?-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia

1998 • 331 citations

Changes in pathological findings at autopsy in AIDS cases for the last 15 years

2000 • 327 citations

Brain pathology induced by infection with the human immunodeficiency virus (HIV)

1987 • 315 citations

HIV antigen in the brains of patients with the AIDS dementia complex

1987 • 289 citations

Blood‐brain barrier abnormalities in acquired immunodeficiency syndrome: Immunohistochemical localization of serum proteins in postmortem brain

1992 • 275 citations

Human immunodeficiency virus-1 infection of the nervous system: An autopsy study of 268 adult, pediatric, and fetal brains

1991 • 269 citations

AIDS dementia complex and HIV‐1 brain infection: Clinical‐virological correlations

1995 • 254 citations

Distribution of Brain HIV Load in AIDS

1998 • 252 citations

Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex

1999 • 238 citations

Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia

1999 • 231 citations

Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.

1993 • 224 citations

HIV-Related Neuropathology, 1985 to 1999: Rising Prevalence of HIV Encephalopathy in the Era of Highly Active Antiretroviral Therapy

2002 • 224 citations

Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia

1999 • 204 citations

Changing Patterns in the Neuropathogenesis of HIV During the HAART Era

2003 • 189 citations

Early Brain Changes in HIV Infection

1992 • 167 citations

Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis

2002 • 160 citations

The neuropathology of adult HIV infection.

1998 • 154 citations

AIDS dementia complex: evaluation with proton MR spectroscopic imaging.

1995 • 147 citations

Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex

1996 • 143 citations

Human Immunodeficiency Virus (HIV) Leukoencephalopathy and the Microcirculation

1990 • 132 citations

HIV-related metabolic abnormalities in the brain: depiction with proton MR spectroscopy with short echo times.

1996 • 131 citations

Cerebrospinal fluid HIV-1 RNA levels

1998 • 126 citations

HIV Infection of Human Choroid Plexus

1995 • 115 citations

Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia

2000 • 113 citations

HIV-1 infection alters monocyte interactions with human microvascular endothelial cells.

1995 • 106 citations

Exogenous tat protein activates central nervous system-derived endothelial cells

1994 • 96 citations

Cerebrovascular changes in the basal ganglia with HIV dementia

2000 • 90 citations

Interactions between macrophages and brain microvascular endothelial cells: role in pathogenesis of HIV-1 infection and blood-brain barrier function

1999 • 88 citations

Absolute Quantitation of Short TE Brain 1H-MR Spectra and Spectroscopic Imaging Data

1993 • 87 citations

Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases

2000 • 82 citations

Brain Proton Magnetic Resonance Spectroscopy in HIV-Related Encephalopathy: Identification of Evolving Metabolic Patterns in Relation to Dementia and Therapy

1997 • 81 citations

The role of the blood-brain barrier in HIV infection of the central nervous system

1994 • 79 citations

HIV-1 Proviral DNA Load Across Neuroanatomic Regions of Individuals With Evidence for HIV-1-Associated Dementia

1997 • 75 citations

A randomized clinical trial of CPI-1189 for HIV-associated cognitive–motor impairment

2002 • 74 citations

Quantitative contrast-enhanced magnetic resonance imaging to evaluate blood-brain barrier integrity in multiple sclerosis: a preliminary study

2001 • 74 citations

A modified protocol to improve the detection of enhancing brain and spinal cord leasions in multiple sclerosis

2001 • 74 citations

CSF, Plasma Viral Load and HIV Associated Dementia

1998 • 72 citations

Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1-infected individuals—correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels

2001 • 70 citations

The relationship between age and cognitive impairment in HIV‐1 infection

1994 • 65 citations

Increased cerebral blood volume in HIV‐positive patients detected by functional MRI

1998 • 65 citations

Human immunodeficiency virus type 1 TAT protein induces adhesion molecule expression in astrocytes

1999 • 64 citations

Understanding pathogenesis and treatment of HIV dementia: a role for magnetic resonance?

2002 • 58 citations

AIDS-associated mild neurocognitive impairment is delayed in the era of highly active antiretroviral therapy

2001 • 57 citations

Assessing the Efficacy of Highly Active Antiretroviral Therapy in the Brain

2003 • 52 citations

Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: A coregistered1H MRS and SPECT study

2000 • 49 citations

Frequency and topographical distribution of CD68-positive macrophages and HIV-1 core proteins in HIV-associated brain lesions.

1993 • 41 citations

Increasing Cerebrospinal Fluid Chemokine Concentrations Despite Undetectable Cerebrospinal Fluid HIV RNA in HIV-1???Infected Patients Receiving Antiretroviral Therapy

2000 • 39 citations

Deep gray matter structures in HIV infection: a proton MR spectroscopic study.

1996 • 37 citations

Cerebral Metabolic Alterations in Human Immunodeficiency Virus-Related Encephalopathy Detected by Proton Magnetic Resonance Spectroscopy

1997 • 34 citations

Astrocytic adhesion molecules are increased in HIV‐1‐associated cognitive/motor complex

1997 • 31 citations

Vascular changes in the cerebral cortex in HIV-1 infection: I. A morphometric investigation by light and electron microscopy.

1996 • 26 citations

HIV-1 RNA levels in the cerebrospinal fluid may increase owing to damage to the blood-brain barrier.

1997 • 20 citations

Brain HIV burden and length of survival after AIDS diagnosis.

1998 • 18 citations

HIV neuropathogenesis.

1997 • 2 citations