High density lipoproteins and reverse cholesterol transport: Lessons from mutations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Molecular physiology of reverse cholesterol transport.

1995 • 1,452 citations

Early incorporation of cell-derived cholesterol into pre-.beta.-migrating high-density lipoprotein

1988 • 643 citations

Meeting Highlights

1996 • 497 citations

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.

1995 • 416 citations

Apolipoprotein-mediated removal of cellular cholesterol and phospholipids

1996 • 346 citations

Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.

1991 • 331 citations

Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.

1982 • 296 citations

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

1997 • 285 citations

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.

1995 • 279 citations

Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol

1991 • 259 citations

Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases

1994 • 207 citations

Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides

1995 • 188 citations

Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes.

1996 • 180 citations

A plasma lipoprotein containing only apolipoprotein Eand with gamma mobility on electrophoresis releases cholesterol fromcells.

1994 • 177 citations

Phospholipid transfer protein mediated conversion of high density lipoproteins generates preβ1-HDL

1996 • 169 citations

Independent Pathways for Secretion of Cholesterol and Apolipoprotein E by Macrophages

1983 • 162 citations

Physiological role and clinical relevance of high-density lipoprotein subclasses

1994 • 153 citations

Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apo A-I from HDL and subsequent formation of discoidal HDL

1992 • 150 citations

Apolipoprotein E Produced by Human Monocyte-derived Macrophages Mediates Cholesterol Efflux That Occurs in the Absence of Added Cholesterol Acceptors

1996 • 147 citations

Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3.

1994 • 135 citations

Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities.

1992 • 130 citations

Regulation of Cellular Cholesterol Efflux by Lecithin:Cholesterol Acyltransferase Reaction through Nonspecific Lipid Exchange

1996 • 121 citations

Apolipoprotein E secretion by macrophages: its potential physiological functions

1996 • 118 citations

Serum Albumin Is a Significant Intermediate in Cholesterol Transfer between Cells and Lipoproteins

1996 • 113 citations

Regulation of the concentration of pre.beta. high-density lipoprotein in normal plasma by cell membranes and lecithin-cholesterol acyltransferase activity

1992 • 110 citations

Increased prebeta-HDL levels, cholesterol efflux, and LCAT-mediated esterification in mice expressing the human cholesteryl ester transfer protein (CETP) and human apolipoprotein A-I (apoA-I) transgenes.

1996 • 108 citations

Quantitation of pre.beta.-HDL-dependent and nonspecific components of the total efflux of cellular cholesterol and phospholipid

1993 • 107 citations

Pre-β HDL: structure and metabolism

1996 • 89 citations

Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.

1994 • 85 citations

Reverse Cholesterol Transport in Plasma of Patients With Different Forms of Familial HDL Deficiency

1995 • 85 citations

Cholesterol efflux from macrophages and other cells

1996 • 78 citations

Lipoproteins Containing Apolipoprotein A-IV but Not Apolipoprotein A-I Take Up and Esterify Cell-Derived Cholesterol in Plasma

1995 • 78 citations

Cycling of apolipoprotein A-I between lipid-associated and lipid-free pools

1995 • 76 citations

An investigation of the role of lecithin: cholesterol acyltransferase and triglyceride-rich lipoproteins in the metabolism of pre-beta high density lipoproteins

1991 • 72 citations

Remodelling of reconstituted high density lipoproteins by lecithin: cholesterol acyltransferase

1996 • 71 citations

Characterization of apoA-IV-containing lipoprotein particles isolated from human plasma and interstitial fluid.

1993 • 67 citations

Independent Regulation of Cholesterol Incorporation into Free Apolipoprotein-mediated Cellular Lipid Efflux in Rat Vascular Smooth Muscle Cells

1995 • 65 citations

Apolipoprotein A-I-containing lipoproteins, with or without apolipoprotein A-II, as progenitors of pre-.beta. high-density lipoprotein particles

1993 • 65 citations

Biochemical Characterization of Pre-β₁ High-Density Lipoprotein from Human Ovarian Follicular Fluid: Evidence for the Presence of a Lipid Core^,

1996 • 64 citations

Interconversion of prebeta-migrating lipoproteins containing apolipoprotein A-I and HDL.

1990 • 64 citations

Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.

1995 • 63 citations

Role of HDL Apolipoprotein E in Cellular Cholesterol Efflux: Studies in Apo E Knockout Transgenic Mice

1994 • 60 citations

Compound Heterozygosity for a Structural Apolipoprotein A-I Variant, Apo A-I(L141R) _Pisa , and an Apolipoprotein A-I Null Allele in Patients With Absence of HDL Cholesterol, Corneal Opacifications, and Coronary Heart Disease

1996 • 59 citations

Synthesis and secretion of apoE in thioglycolate-elicited mouse peritoneal macrophages: effect of cholesterol efflux.

1989 • 59 citations

Lecithin:cholesterol acyltransferase reaction on cellular lipid released by free apolipoprotein-mediated efflux

1995 • 54 citations

Characterization of human plasma apolipoprotein E-containing lipoproteins in the high density lipoprotein size range: focus on pre-beta1-LpE, pre-beta2-LpE, and alpha-LpE.

1997 • 52 citations

Evidence for the separation of albumin- and apo A-I-dependent mechanisms of cholesterol efflux from cultured fibroblasts into human plasma.

1982 • 51 citations

Comparison of apo A-I-containing subpopulations of dog plasma and prenodal peripheral lymph: evidence for alteration in subpopulations in the interstitial space

1993 • 46 citations

Dissociation of high density lipoprotein precursors from apolipoprotein B-containing lipoproteins in the presence of unesterified fatty acids and a source of apolipoprotein A-I.

1991 • 44 citations

A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma

1997 • 37 citations

Formation of new HDL particles from lipid-free apolipoprotein A-I.

1996 • 35 citations

Generation of Pre-β ₁ -HDL and Conversion Into α-HDL

1995 • 27 citations

Effects of Genotype and Diet on Cholesterol Efflux into Plasma and Lipoproteins of Normal, Apolipoprotein A-I-, and Apolipoprotein E-Deficient Mice

1997 • 23 citations

Phenotype dependent differences in apolipoprotein E gene expression and protein secretion in human monocyte-derived macrophages

1996 • 3 citations

Defective cholesterol efflux into plasmas of apolipoprotein E-deficient men and mice

1997 • 1 citations