Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA

1982 • 668 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

1989 • 569 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

1982 • 540 citations

Viral and cellular fos proteins: A comparative analysis

1984 • 523 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Identification of a major keratinocyte cell envelope protein, loricrin

1990 • 420 citations

Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues.

1984 • 406 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

1986 • 235 citations

Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis

1981 • 228 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

The fos Oncogene

1987 • 196 citations

Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins

1987 • 187 citations

Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.

1988 • 183 citations

Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis.

1988 • 182 citations

Collagenolytic mechanisms in tumor cell invasion

1984 • 146 citations

Early signals for keratinocyte differentiation: role of Ca²⁺-mediated inositol lipid metabolism in normal and neoplastic epidermal cells

1988 • 140 citations

Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes

1989 • 136 citations

Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H- ras p21

1987 • 134 citations

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

1987 • 131 citations

Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons

1989 • 124 citations

Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses

1985 • 112 citations

Aberrant expression during two‐stage mouse skin carcinogenesis of a type 147‐kDa keratin, k13, normally associated with terminal differentiation of internal stratified epithelia

1988 • 98 citations

Signal Transduction for Proliferation and Differentiation in Keratinocytes

1988 • 96 citations

Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts.

1988 • 94 citations

Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture.

1988 • 88 citations

Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.

1990 • 87 citations

Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol

1986 • 80 citations

Regression kinetics of mouse skin papillomas.

1976 • 77 citations

Association of DNA strand breaks with accelerated terminal differentiation in mouse epidermal cells exposed to tumor promoters.

1985 • 64 citations

Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.

1985 • 62 citations

Altered growth and differentiation of cultured mouse epidermal cells infected with oncogenic retrovirus: contrasting effects of viruses and chemicals.

1983 • 61 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas.

1988 • 53 citations

Hidden self‐association of proteins

1989 • 47 citations

Phospholipid metabolism in calcium-regulated differentiation in cultured murine keratinocytes

1984 • 47 citations

Transfection of the EJ ras^Ha Gene into Keratinocytes Derived from Carcinogen-Induced Mouse Papillomas Causes Malignant Progression

1986 • 47 citations

Differential distribution of cytokeratins after microinjection of anti-cytokeratin monoclonal antibodies.

1987 • 42 citations

Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression.

1986 • 41 citations

Keratin gene expression in simian virus 40-transformed human keratinocytes.

1985 • 40 citations

Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N′-nitro-N-nitrosoguanidine, or 12-O-tetradecanoylphorbol-13-acetate

1986 • 34 citations

Analysis of the ras^H oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines

1987 • 33 citations

Heterogeneity of [3H]phorbol 12,13-dibutyrate binding in primary mouse keratinocytes at different stages of maturation.

1985 • 30 citations

Chapter 6 Developmental Expression of Human Epidermal Keratins and Filaggrin

1987 • 28 citations

Sequential Changes in Gene Expression during Epidermal Differentiation

1988 • 23 citations

Alteration in the distribution of the epidermal protein filaggrin during two-stage chemical carcinogenesis in the SENCAR mouse skin.

1984 • 22 citations

Malignant progression of papilloma‐derived keratinocytes: Differential effects of the ras, neu, and p⁵³ oncogenes

1988 • 19 citations

Malignant transformation of a preneoplastic hamster epidermal cell line by the EJ c-Ha-ras-oncogene.

1986 • 18 citations

Cellular and molecular changes during chemical carcinogenesis in mouse skin cells.

1985 • 16 citations

Consequences of exposure to initiating levels of carcinogens in vitro and in vivo: altered differentiation and growth, mutations, and transformation.

1989 • 11 citations

Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H-ras p21

1988 • 10 citations

Proteinases and their Inhibitors in Cells and Tissues

1989 • 10 citations