Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

2002 • 3,174 citations

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

1998 • 1,432 citations

The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

1985 • 1,251 citations

Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials

1998 • 1,090 citations

5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review

2000 • 1,041 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Neurotoxicity associated with dual actions of homocysteine at the N -methyl- <scp>d</scp> -aspartate receptor

1997 • 830 citations

Brain hydrogen sulfide is severely decreased in Alzheimer's disease

2002 • 773 citations

Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

2000 • 765 citations

Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase

1997 • 670 citations

Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease

2002 • 638 citations

The metabolism of homocysteine: pathways and regulation

1998 • 583 citations

Vitamin dificiencies and neural tube defects.

1976 • 580 citations

The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine

1992 • 562 citations

Homocysteine, folate, methylation, and monoamine metabolism in depression

2000 • 550 citations

The Quantitatively Important Relationship between Homocysteine Metabolism and Glutathione Synthesis by the Transsulfuration Pathway and Its Regulation by Redox Changes

2000 • 495 citations

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome

1999 • 454 citations

Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.

1995 • 421 citations

Total serum homocysteine in senile dementia of Alzheimer type

1998 • 410 citations

Folate Status: Effects on Pathways of Colorectal Carcinogenesis

2002 • 392 citations

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

2001 • 392 citations

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene.

2000 • 390 citations

Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage

2002 • 369 citations

Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development

1999 • 362 citations

Energy Thresholds in Brain Mitochondria

1998 • 354 citations

Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases

1999 • 344 citations

The Mutation Ala677→Val in the Methylene Tetrahydrofolate Reductase Gene: A Risk Factor for Arterial Disease and Venous Thrombosis

1997 • 313 citations

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

1995 • 304 citations

Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.

1992 • 301 citations

CARRIER-MEDIATED MEMBRANE TRANSPORT OF FOLATES IN MAMMALIAN CELLS

1999 • 296 citations

Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun Study

2000 • 278 citations

Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene

1996 • 273 citations

Homocysteine potentiates β‐amyloid neurotoxicity: role of oxidative stress

2001 • 263 citations

Brain S‐Adenosylmethionine Levels Are Severely Decreased in Alzheimer's Disease

1996 • 261 citations

Identification of Cognitive Impairment in the Elderly: Homocysteine Is an Early Marker

1998 • 259 citations

A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk.

1999 • 259 citations

Homocysteine potentiates copper‐ and amyloid beta peptide‐mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's‐type neurodegenerative pathways

2001 • 258 citations

Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.

1990 • 258 citations

PATHOGENESIS OF SUBACUTE COMBINED DEGENERATION: A RESULT OF METHYL GROUP DEFICIENCY

1981 • 248 citations

The “Thermolabile” Variant of Methylenetetrahydrofolate Reductase and Neural Tube Defects: An Evaluation of Genetic Risk and the Relative Importance of the Genotypes of the Embryo and the Mother

1999 • 248 citations

Folate Improves Endothelial Function in Coronary Artery Disease

2001 • 241 citations

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

1999 • 238 citations

Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation

2001 • 237 citations

Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat

1991 • 207 citations

Folate Depletion and Elevated Plasma Homocysteine Promote Oxidative Stress in Rat Livers

2001 • 206 citations

Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial

2002 • 199 citations

Is Metabolic Evidence for Vitamin B-12 and Folate Deficiency More Frequent in Elderly Patients With Alzheimer's Disease?

1997 • 195 citations

Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia

2000 • 172 citations

Functional vitamin B ₁₂ deficiency and Alzheimer disease

2002 • 166 citations

Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings

1997 • 163 citations

Functional methionine synthase deficiency (cblE and cblG): Clinical and biochemical heterogeneity

1989 • 160 citations

Folate deficiency in depressive illness.

1970 • 159 citations

Nutrition and depression: focus on folate

2000 • 151 citations

Folate Deficiency in Depressive Illness

1970 • 150 citations

Folic Acid, Homocysteine and One-Carbon Metabolism: A Review of the Essential Biochemistry

1998 • 146 citations

Maternal Genetic Effects, Exerted by Genes Involved in Homocysteine Remethylation, Influence the Risk of Spina Bifida

2002 • 145 citations

Homocysteine and stroke

2001 • 140 citations

Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD

2000 • 132 citations

A Mechanism for the Neuroprotective Effect of Apolipoprotein E

2000 • 129 citations

Endoplasmic Reticulum Stress-inducible Protein, Herp, Enhances Presenilin-mediated Generation of Amyloid β-Protein

2002 • 124 citations

Homocysteine and Alzheimer's Disease

2009 • 122 citations

Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry

1998 • 121 citations

Reduced vitamin B12 binding by transcobalamin II increases the risk of neural tube defects

2001 • 115 citations

Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue

2002 • 110 citations

Plasma Homocysteine and l-DOPA Metabolism in Patients with Parkinson Disease

2001 • 106 citations

Homocysteinemia is a common feature of schizophrenia

1995 • 104 citations

Bioenergetics in Huntington's Disease

1999 • 103 citations

Is Hyperhomocysteinemia due to the Oxidative Depletion of Folate rather than to Insufficient Dietary Intake?

2001 • 102 citations

CSF-folate levels are decreased in late-onset AD patients

2001 • 101 citations

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B₁₂

2002 • 99 citations

Schizophrenia and impaired homocysteine metabolism: a possible association

1998 • 97 citations

Apoptotic and Anti‐Apoptotic Synaptic Signaling Mechanisms

2000 • 94 citations

Effect of folic acid and vitamin B₁₂ deficiencies on 5‐hydroxyindoleacetic acid in human cerebrspinal fluid

1982 • 94 citations

Oxidative stress and neural dysfunction in Down Syndrome

1999 • 92 citations

Strategies for the treatment of cystathionine β-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years

1998 • 91 citations

Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect

2001 • 86 citations

Function of vitamin B₁₂ in the central nervous system as revealed by congenital defects

1990 • 74 citations

An Ultrastructural Study of Subacute Combined Degeneration of the Spinal Cord in Vitamin B12-Deficient Rhesus Monkeys

1978 • 72 citations

Nutrition and dementia

1989 • 70 citations

Symptomatic and asymptomatic methylenetetrahydrofolate reductase deficiency in two adult brothers

1993 • 67 citations

Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E

2002 • 65 citations

Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease

1998 • 64 citations

Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia

2001 • 61 citations

Apolipoprotein E, Methylenetetrahydrofolate Reductase(MTHFR) Mutation and the Risk of Senile Dementia. An Epidemiological Study Using the Polymerase Chain Reaction(PCR) Method.

2000 • 60 citations

Effects of L-dopa treatment on methylation in mouse brain: Implications for the side effects of L-dopa

2000 • 56 citations

The Centrality of S-Adenosylhomocysteinase in the Regulation of the Biological Utilization of S-Adenosylmethionine

1986 • 55 citations

Cerebrospinal Fluid and Plasma Total Homocysteine and Related Metabolites in Children with Cystathionine β-Synthase Deficiency: The Effect of Treatment

1997 • 52 citations

Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis

1997 • 51 citations

Vitamins C, E and A and Heme Oxygenase in Rats Fed Methyl/Folate-Deficient Diets11This work was supported by NIH grant CA42710-10 and Westreco Inc., Van Nuys, CA.

1997 • 49 citations

Homocysteic and homocysteine sulphinic acid exhibit excitotoxicity in organotypic cultures from rat brain

1998 • 39 citations

Neurological involvement in hereditary transcobalamin II deficiency.

1982 • 37 citations

Folate–vitamin B₁₂interrelationships in the central nervous system

1992 • 36 citations

Incorporating biomarkers into clinical drug trials in Alzheimer's disease

2001 • 36 citations

An Open-Label, 24-Week Pilot Study of the Methyl Donor Betaine in Alzheimer Disease Patients

2001 • 32 citations

Homocysteine and Alzheimer's disease

2003 • 31 citations

Folic Acid and B12 in Autism and Neuropsychiatric Disturbances of Childhood

1981 • 24 citations

Long term treatment with betaine in methylenetetrahydrofolate reductase deficiency.

1996 • 23 citations

[Antidepressive effect of pyridoxine (vitamin B6) in neuroleptic-treated schizophrenic patients with co-morbid minor depression--preliminary open-label trial].

2001 • 18 citations

Folic acid has a disinhibitory action in the rat hippocampal slice preparation

1985 • 17 citations

Differential effects on growth, homocysteine, and related compounds of two inhibitors of S-adenosylhomocysteine catabolism, 3-deazaadenosine, and 3-deazaaristeromycin, in C3H/10T1/2 cells.

1989 • 16 citations

Single-channel currents of NMDA type activated by l- and d-homocysteic acid in cerebellar granule cells in culture

1992 • 8 citations

[Cerebral vascular complication of hyperhomocysteinemia. Controlling thromboembolic complications with folates].

1997 • 6 citations