The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis

1988 • 1,306 citations

The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

1985 • 1,251 citations

Effects of ingestion of disproportionate amounts of amino acids.

1970 • 1,123 citations

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1987 • 1,072 citations

Disorders of transsulfuration

1989 • 1,053 citations

Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease

1985 • 739 citations

Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy.

1989 • 615 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

Labile methyl balances for normal humans on various dietary regimens

1975 • 492 citations

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

1988 • 479 citations

Homocysteinemia due to folate deficiency

1987 • 423 citations

Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.

1984 • 414 citations

The Metabolic Basis of Inherited Disease.

1991 • 409 citations

Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment

1990 • 397 citations

Folic acid—an innocuous means to reduce plasma homocysteine

1988 • 368 citations

Mammalian methylenetetrahydrofolate reductase Partial purification, properties, and inhibition by S-adenosylmethionine

1971 • 349 citations

Plasma homocyst(e)ine levels in men with premature coronary artery disease

1990 • 304 citations

Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry

1987 • 291 citations

Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.

1984 • 290 citations

Activation of cystathionine synthase by adenosylmethionine and adenosylethionine

1975 • 277 citations

Homocystinuria — The Effects of Betaine in the Treatment of Patients Not Responsive to Pyridoxine

1983 • 247 citations

Homocystinuria associated with decreased methylenetetrahydrofolate reductase activity

1972 • 232 citations

Higher total plasma homocysteine in vitamin B12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthase deficiency

1988 • 227 citations

Labile methyl group balances in the human: The role of sarcosine

1980 • 206 citations

Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine

1967 • 204 citations

Homocysteine and myocardial infarction

1988 • 197 citations

Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: Possible implications for prevention of vascular disease

1988 • 197 citations

Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium.

1987 • 159 citations

A derangement in B12 metabolism associated with homocystinemia, cystathioninemia, hypomethioninemia and methylmalonic aciduria

1970 • 147 citations

Homocysteine in the Plasma of Renal Transplant Recipients: Effects of Cofactors for Methionine Metabolism

1981 • 144 citations

Methionine intolerance: A possible risk factor for coronary artery disease

1985 • 144 citations

Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria

1983 • 138 citations

Homocystinuria with methylmalonic aciduria: Two cases in a sibship

1970 • 137 citations

Morphologic Studies in a Patient with Homocystinuria due to 5,10-Methylenetetrahydrofolate Reductase Deficiency

1976 • 121 citations

The use of betaine for the treatment of homocystinuria

1981 • 119 citations

Accumulation of Homocyst(e)ine in Vitamin B-6 Deficiency: a Model for the Study of Cystathionine β-Synthase Deficiency

1982 • 113 citations

Folic acid responsive postmenopausal homocysteinemia

1985 • 105 citations

Effect of Vitamin B6 Depletion in Adult Man on the Excretion of Cystathionine and Other Methionine Metabolites

1970 • 101 citations

Determination of plasma homocysteine by high-performance liquid chromatography with fluorescence detection

1989 • 100 citations

Homocystinuria due to Cystathionine Synthetase Deficiency: The Mode of Inheritance

1964 • 99 citations

Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency.

1988 • 95 citations

Choline dehydrogenase

1981 • 93 citations

Detection of heterozygotes for homocystinuria: Study of sulphur-containing amino acids in plasma and urine after L-methionine loading

1974 • 92 citations

Improved identification of heterozygotes for homocystinuria due to cystathionine synthase deficiency by the combination of methionine loading and enzyme determination in cultured fibroblasts

1985 • 92 citations

Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine: Methionine loading of non‐transformed, transformed, proliferating, and quiescent cells in culture

1991 • 87 citations

Homocystinuria due to cystathionine β-synthase deficiency—The effects of betaine treatment in pyridoxine-responsive patients

1985 • 86 citations

Effects of deficiency of vitamin B6 on transsulfuration

1969 • 79 citations

Mental Retardation, Megaloblastic Anaemia, Methylmalonic Aciduria and Abnormal Homocysteine Metabolism Due to an Error in Vitamin B12 Metabolism

1974 • 79 citations

Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine

1984 • 78 citations

Deranged B12 metabolism: Effects on sulfur amino acid metabolism

1970 • 77 citations

Deranged B12 metabolism: Studies of fibroblasts grown in tissue culture

1970 • 70 citations

Homocysteine in tissues of the mouse and rat.

1984 • 68 citations

Homocyst(e)ine Accumulation in Pigs Fed Diets Deficient in Vitamin B-6: Relationship to Atherosclerosis

1983 • 67 citations

The Total Serum Homocysteine as an Indicator of Vitamin B12 and Folate Status

1988 • 58 citations

Tryptophan and Methionine Metabolism of Adult Females as Affected by Vitamin B-6 Deficiency

1974 • 58 citations

Methods for the estimation of three vitamin dependent red cell enzymes.

1976 • 52 citations

The substrate specificity of 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase

1969 • 50 citations

Pyridoxine Effects on Cystathionine Synthase in Rat Liver

1970 • 49 citations

Factors Affecting the Accumulation of Homocyst(e)ine in Rats Deficient in Vitamin B-6

1984 • 44 citations

Synchronization of Converging Metabolic Pathways: Activation of the Cystathionine γ-Synthase of Neurospora crassa by Methyltetrahydrofolate

1971 • 42 citations

HOMOCYSTINURIA AND ORGANIC ACIDURIA IN A PATIENT WITH VITAMIN-B12 DEFICIENCY

1969 • 41 citations

Effect of vitamin B-6 (pyridoxine) deficiency on lung elastin cross-linking in perinatal and weanling rat pups

1985 • 36 citations

Pyridoxine treatment does not prevent homocystinemia after methionine loading in adult homocystinuria patients

1983 • 35 citations

Clinical Chemistry of Vitamin B12

1985 • 34 citations

Homocysteinemia in rats induced by folic acid deficiency

1989 • 34 citations

Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism.

1986 • 26 citations

Effect of trypsin, S-adenosylmethionine and ethionine on L-serine sulfhydrase activity

1977 • 23 citations

Free and protein-bound homocysteine and cysteine in cystathionine β-synthase deficiency: Interrelations during short- and long-term changes in plasma concentrations

1989 • 21 citations

Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomes

1986 • 20 citations

Excretion of S-Adenosylmethionine and S-Adenosylhomocysteine in Homocystinuria

1971 • 19 citations

Adaptation of Adenosylmethionine Metabolism and Methionine Recycling to Variations in Dietary Methionine in the Rat

1990 • 18 citations

Disposition of homocysteine and S-3-deazaadenosylhomocysteine in cells exposed to 3-deazaadenosine.

1986 • 16 citations

Total homocysteine in fasting plasma is not a good indicator of b6 deficiency

1991 • 7 citations

Deleted Work

1955 • 0 citations