The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 • 596 citations

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1990 • 410 citations

Quantitative Analysis of the Complex between p21 and the Ras-binding Domain of the Human Raf-1 Protein Kinase

1995 • 348 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

1996 • 328 citations

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site.

1986 • 287 citations

Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1

1991 • 280 citations

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

1998 • 265 citations

Structural basis for the interaction of Ras with RaIGDS

1998 • 251 citations

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1998 • 220 citations

A rapid and efficient one-tube PCR-based mutagenesis technique usingPfuDNA polymerase

1994 • 218 citations

Evidence for a Ras/Ral signaling cascade

1996 • 214 citations

Inhibition of Ras-Induced DNA Synthesis by Expression of the Phosphatase MKP-1

1994 • 214 citations

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.

1993 • 174 citations

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes

1986 • 168 citations

Ras effectors and their role in mitogenesis and oncogenesis

1997 • 167 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex

1994 • 167 citations

Ras caught in another affair: the exchange factors for Ral

1999 • 156 citations

Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 151 citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activationin vivoandin vitro

1997 • 140 citations

Thermodynamic and Kinetic Characterization of the Interaction between the Ras Binding Domain of AF6 and Members of the Ras Subfamily

1999 • 132 citations

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex

1998 • 129 citations

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex.

1991 • 128 citations

The Drosophila Roughened mutation: Activation of a rap homolog disrupts eye development and interferes with cell determination

1991 • 123 citations

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.

1992 • 107 citations

Glial Cell Line-derived Neurotrophic Factor Induces Ret-mediated Lamellipodia Formation

1997 • 106 citations

Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

1992 • 106 citations

Structural and biochemical analysis of Ras‐effector signaling via RalGDS

1999 • 99 citations

Regulation of Sos Activity by Intramolecular Interactions

1998 • 98 citations

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

1999 • 89 citations

Ral-Specific Guanine Nucleotide Exchange Factor Activity Opposes Other Ras Effectors in PC12 Cells by Inhibiting Neurite Outgrowth

1999 • 88 citations

Interactions between Ras proteins and their effectors

1996 • 82 citations

Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

1997 • 67 citations

smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells.

1992 • 63 citations

rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral

1997 • 60 citations

Mutational Analysis of the Role of Rap1 in Regulating Cytoskeletal Function inDictyostelium

1997 • 43 citations

Ultrastructural localization of the small GTP‐binding protein Rap 1 in human platelets and megakaryocytes

1994 • 42 citations

Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation

1997 • 36 citations

The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways

2000 • 29 citations

The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells

1996 • 22 citations

Isolation and characterization of the krev-1 gene, a novel member of ras superfamily in Neurospora crassa: involvement in sexual cycle progression

1997 • 21 citations

Partial growth suppression of human prostate cancer cells by the Krev‐1 suppressor gene

1994 • 16 citations

Enhanced Krev-1 Expression Inhibits the Growth of Pancreatic Adenocarcinoma Cells

1998 • 9 citations

Expression of humanKrev-1 gene in lungs of transgenic mice and subsequent reduction in multiplicity of ethyl carbamate-induced lung adenomas

1996 • 8 citations

Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev‐1

1992 • 7 citations