Mechanisms of tumor cell invasion and angiogenesis in the central nervous system

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

2000 • 4,734 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

1992 • 1,514 citations

Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

1999 • 1,494 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

A common progenitor for neurons and glia persists in rat retina late in development

1987 • 1,395 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat

1993 • 1,215 citations

Anti-Angiogenesis

1972 • 1,167 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Regulatory Mechanisms in Stem Cell Biology

1997 • 1,060 citations

Angiogenesis and Tumor Metastasis

1998 • 1,013 citations

A unified hypothesis on the lineage of neural stem cells

2001 • 976 citations

Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS

1999 • 916 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

2000 • 750 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Multipotent progenitor cells in the adult dentate gyrus

1998 • 722 citations

Protein function in the post-genomic era

2000 • 721 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Widespread Dispersion of Neuronal Clones Across Functional Regions of the Cerebral Cortex

1992 • 610 citations

Glioma Invasion in the Central Nervous System

1996 • 574 citations

Vascular Endothelial Growth Factor, a Potent and Selective Angiogenic Agent

1996 • 570 citations

Endothelial proliferation in tumours and normal tissues: Continuous labelling studies

1984 • 562 citations

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.

1993 • 534 citations

Clonally Related Cortical Cells Show Several Migration Patterns

1988 • 510 citations

Structure and Function of VEGF/VEGF-receptor System Involved in Angiogenesis.

2001 • 508 citations

Architecture and cell types of the adult subventricular zone: In search of the stem cells

1998 • 484 citations

Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possibleIn vivo regulatory mechanisms

1994 • 464 citations

Maspin is an angiogenesis inhibitor

2000 • 463 citations

Canstatin, a Novel Matrix-derived Inhibitor of Angiogenesis and Tumor Growth

2000 • 461 citations

Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus

1984 • 453 citations

Cell lineage in the rat cerebral cortex: a study using retroviral-mediated gene transfer

1988 • 421 citations

METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity

1999 • 420 citations

Anti-angiogenic cues from vascular basement membrane collagen.

2000 • 412 citations

Division and differentiation of isolated CNS blast cells in microculture

1989 • 404 citations

Continuous release of endostatin from microencapsulated engineered cells for tumor therapy

2001 • 372 citations

Expression of the class VI intermediate filament nestin in human central nervous system tumors.

1992 • 369 citations

Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence.

1996 • 353 citations

Randomized Phase II Trial of Docetaxel Plus Thalidomide in Androgen-Independent Prostate Cancer

2004 • 353 citations

Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques.

2000 • 329 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis.

1993 • 321 citations

Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth

1998 • 314 citations

A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer.

2001 • 312 citations

Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan

1987 • 306 citations

Local endostatin treatment of gliomas administered by microencapsulated producer cells

2001 • 303 citations

Kringle 5 of Plasminogen is a Novel Inhibitor of Endothelial Cell Growth

1997 • 294 citations

Cell turnover of capillaries.

1967 • 294 citations

Glial-Restricted Precursors Are Derived from Multipotent Neuroepithelial Stem Cells

1997 • 287 citations

Antiangiogenic Activity of Restin, NC10 Domain of Human Collagen XV: Comparison to Endostatin

1999 • 280 citations

Phase I Study of Recombinant Human Endostatin in Patients With Advanced Solid Tumors

2002 • 276 citations

The generation of neurons and oligodendrocytes from a common precursor cell

1991 • 274 citations

The primary structure of NG2, a novel membrane-spanning proteoglycan.

1991 • 257 citations

Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein

1994 • 244 citations

Long-term reversal of diabetes by the injection of immunoprotected islets.

1993 • 239 citations

Two RGD-independent αvβ3 Integrin Binding Sites on Tumstatin Regulate Distinct Anti-tumor Properties

2000 • 229 citations

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

1999 • 222 citations

Troponin I is present in human cartilage and inhibits angiogenesis

1999 • 221 citations

Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma

1998 • 204 citations

The role of matrix metalloproteinases in glioma invasion

2003 • 194 citations

Angiostatin suppresses malignant glioma growth in vivo.

1998 • 189 citations

Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors

1999 • 189 citations

Suppression of angiogenesis and tumor growth by the inhibitor K1–5 generated by plasmin-mediated proteolysis

1999 • 186 citations

Progenitor cells and glioma formation

2001 • 181 citations

Control of cell motility and tumour invasion by extracellular matrix interactions

1992 • 180 citations

Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.

1998 • 173 citations

Molecular Interactions of Neural Chondroitin Sulfate Proteoglycans in the Brain Development

2000 • 165 citations

Expression of Integrin ανβ3 in Small Blood Vessels of Glioblastoma Tumors

1996 • 163 citations

Effects of EGF, BFGF, NGF and PDGF(bb) on cell proliferative, migratory and invasive capacities of human brain‐tumour biopsies In Vitro

1993 • 163 citations

Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B

1996 • 158 citations

Discussion point Stem cells of the central nervous system

1998 • 156 citations

Stem cells in the developing and adult nervous system

1998 • 155 citations

Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)

1990 • 154 citations

Antiangiogenesis for cancer therapy

1997 • 152 citations

Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms.

2001 • 151 citations

Matrix metalloproteinases and their biological function in human gliomas

1999 • 151 citations

Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.

1996 • 145 citations

gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.

1995 • 138 citations

Angiogenesis and Cancer Control: From Concept to Therapeutic Trial

1999 • 134 citations

AN2/NG2 protein‐expressing glial progenitor cells in the murine CNS: Isolation, differentiation, and association with radial glia

2001 • 131 citations

A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer

2001 • 129 citations

Multi-Institutional Study of the Angiogenesis Inhibitor TNP-470 in Metastatic Renal Carcinoma

1999 • 126 citations

Correction of the Growth Defect in Dwarf Mice with Nonautologous Microencapsulated Myoblasts—An Alternate Approach to Somatic Gene Therapy

1995 • 120 citations

Identification and validation of P311 as a glioblastoma invasion gene using laser capture microdissection.

2001 • 119 citations

Thrombospondin-1 Is Downregulated by Anoxia and Suppresses Tumorigenicity of Human Glioblastoma Cells

2000 • 110 citations

NG2 proteoglycan promotes angiogenesis‐dependent tumor growth in the central nervous system by sequestering angiostatin

2002 • 100 citations

Identification of soluble forms of the fibroblast growth factor receptor in blood.

1994 • 97 citations

SOME OBSERVATIONS ON THE GROWTH AND SURVIVAL-PERIOD OF INTRACRANIAL TUMOURS, BASED ON THE RECORDS OF 500 CASES, WITH SPECIAL REFERENCE TO THE PATHOLOGY OF THE GLIOMATA

1912 • 96 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis

1993 • 96 citations

Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinoma

1999 • 92 citations

Neurogenesis and Neuronal Migration in the Neonatal Rat Forebrain Anterior Subventricular Zone Do Not Require GFAP-Positive Astrocytes

1999 • 91 citations

Treatment of a Lysosomal Storage Disease, Mucopolysaccharidosis VII, with Microencapsulated Recombinant Cells

2000 • 88 citations

Intravital microscopy reveals novel antivascular and antitumor effects of endostatin delivered locally by alginate-encapsulated cells.

2001 • 86 citations

Antiangiogenic Gene Therapy in a Rat Glioma Model Using a Dominant-Negative Vascular Endothelial Growth Factor Receptor 2

1999 • 84 citations

Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF‐α, bFGF, IL‐2] on glioma spheroid growth, migration and invasion

1994 • 84 citations

Cell encapsulation technology as a therapeutic strategy for CNS malignancies

2001 • 82 citations

Transplantation of Encapsulated Bovine Chromaffin Cells in the Sheep Subarachnoid Space: A Preclinical Study for the Treatment of Cancer Pain

1994 • 76 citations

Effect of In Situ Retroviral Interleukin-4 Transfer on Established Intracranial Tumors

1999 • 75 citations

Genetic modulation of hypoxia induced gene expression and angiogenesis relevance to brain tumors

2003 • 74 citations

Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC

2000 • 74 citations

Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas

2001 • 65 citations

Hepatic Progenitors and Strategies for Liver Cell Therapies

2001 • 65 citations

Leptomeningeal Tissue: a Barrier Against Brain Tumor Cell Invasion

1994 • 62 citations

Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus

2001 • 61 citations

Extracellular matrix-induced cell migration from glioblastoma biopsy specimens in vitro

1999 • 57 citations

AUTOLOGOUS GLIOMA TRANSPLANTATION

1960 • 49 citations

From rodent glial precursor cell to human glial neoplasia in the oligodendrocyte‐type‐2‐astrocyte lineage

1995 • 49 citations

Phase II study of the antiangiogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck

2001 • 48 citations

The treatment of established intracranial tumors by in situ retroviral IFN-γ transfer

2000 • 48 citations

Chapter 16 Detection of glioma-associated gangliosides GM2, GD2, GD3, 3′-isoLM1 and 3′,6′-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies

1994 • 47 citations

Clinical studies of angiogenesis inhibitors: The university of texas md anderson center trial of human endostatin

2001 • 46 citations

Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma

2002 • 46 citations

Glioma cell migration is associated with glioma‐induced angiogenesis in vivo

1999 • 45 citations

Growth factors, glia and gliomas.

1997 • 44 citations

Alginate-Encapsulated Producer Cells: A Potential New Approach for the Treatment of Malignant Brain Tumors

2000 • 43 citations

Suramin inhibits glioma cell proliferationin vitro and in the brain

1994 • 42 citations

Expression of Gangliosides GD3 and 3′‐isoLM1 in Autopsy Brains from Patients with Malignant Tumors

1993 • 42 citations

Anti-proliferative effects of TNP-470 on human malignant gliomain vivo: potent inhibition of tumor angiogenesis

1994 • 39 citations

Retinoic Acid Alters the Mechanism of Attachment of Malignant Astrocytoma and Neuroblastoma Cells to Thrombospondin-1

1999 • 39 citations

Gangliosides as diagnostic markers of human astrocytomas and primitive neuroectodermal tumors

1994 • 38 citations

Differentiation and Anaplasia in Central Neuroepithelial Tumors

2015 • 38 citations

The paradox of neoplastic glial cell invasion of the brain and apparent metastatic failure.

1998 • 38 citations

Vascular Endothelial Growth Factor and Glioma Angiogenesis: Coordinate Induction of VEGF Receptors, Distribution of VEGF Protein and Possible In Vivo Regulatory Mechanisms

1995 • 37 citations

Increased levels of plasminogen activator inhibitor-1 (PAI-1) in human brain tumors

1993 • 32 citations

Cell lineage in the cerebral cortex

1991 • 26 citations

Artificial Cells with Emphasis on Cell Encapsulation of Genetically Engineered Cells

1998 • 26 citations

Neoangiogenesis in human astrocytomas expression and functional role of angiopoietins and their cognate receptors

2003 • 25 citations

Human Recombinant Interferon Alpha-2a Inhibits Angiogenesis of Chick Area Vasculosa in Shell-Less Culture

1996 • 23 citations

Isotransplantation of microencapsulated parathyroid tissue in rats

2009 • 21 citations

Localised Delivery of Therapeutic Agents to CNS Malignancies: Old and New Approaches

2002 • 19 citations

Interactions between fetal rat brain cells and mature brain tissue in vivo and in vitro

1994 • 16 citations

Global Transcript Expression Profiling by Serial Analysis of Gene Expression (SAGE)

2006 • 13 citations

A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer

2001 • 13 citations

The presence of foetal ganglioside antigens 3′-IsoLM1 and 3′6′-IsoLD1 in both glioma tissue and surrounding areas from human brain

1997 • 13 citations

Delivery of recombinant product from subcutaneous implants of encapsulated recombinant cells in canines

2000 • 11 citations

Angiogenesis inhibitors

2000 • 11 citations

Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas

2001 • 6 citations

Cell encapsulation technology as a therapeutic strategy for CNS malignancies

2001 • 5 citations

Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma

2002 • 4 citations

INTERACTIONS BETWEEN FETAL RAT BRAIN CELLS AND MATURE BRAIN TISSUE IN VIVO AND IN VITRO

1993 • 4 citations

Angiogenesis Inhibitors

1999 • 3 citations

Direct isolation of human neural stem cells from fetal brain by cell sorting

1999 • 3 citations

AUTOLOGOUS GLIOMA TRANSPLANTATION

1960 • 2 citations

Old and new approaches

2002 • 2 citations