DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals.

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Toxic DNA Damage by Hydrogen Peroxide Through the Fenton Reaction in Vivo and in Vitro

1988 • 1,505 citations

Data for biochemical research

1987 • 1,200 citations

A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

1980 • 1,180 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Radioprotectors and anticarcinogens

1983 • 613 citations

Handbook of Mutagenicity Test Procedures

1984 • 569 citations

Conversion of Amino Acid Residues in Proteins and Amino Acid Homopolymers to Carbonyl Derivatives by Metal-catalyzed Oxidation Reactions

1989 • 488 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.

1978 • 428 citations

Oxidant-induced DNA damage of target cells.

1988 • 382 citations

In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction

1984 • 350 citations

On the cytotoxicity of vitamin C and metal ions

1983 • 328 citations

Oxygen Radicals in Biology and Medicine

1988 • 293 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

Genotoxicity of active oxygen species in mammalian cells

1988 • 244 citations

Activated neutrophils induce prolonged DNA damage in neighboring cells

1988 • 243 citations

Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action

1981 • 205 citations

Hydroxyl free radical formation from hydrogen peroxide by ferrous iron-nucleotide complexes

1983 • 176 citations

The role and mechanism of metal ions and their complexes in enhancing damage in biological systems or in protecting these systems from these systems from the toxicity of O2−

1986 • 174 citations

The analogous mechanisms of enzymatic inactivation induced by ascorbate and superoxide in the presence of copper.

1983 • 165 citations

Effects of antioxidants on oxidant-induced sister chromatid exchange formation.

1985 • 146 citations

Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species

1985 • 139 citations

Lipid peroxidation initiated by superoxide‐dependent hydroxyl radicals using complexed iron and hydrogen peroxide

1984 • 134 citations

Hydroxyl free radical reactions with amino acids and proteins studied by electron spin resonance spectroscopy and spin-trapping

1984 • 129 citations

Direct demonstration that ferrous ion complexes of di- and triphosphate nucleotides catalyze hydroxyl free radical formation from hydrogen peroxide

1983 • 125 citations

Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis.

1982 • 121 citations

Copper-phenanthroline-induced site-specific oxygen-radical damage to DNA. Detection of loosely bound trace copper in biological fluids

1984 • 114 citations

Inactivation of enzymes and oxidative modification of proteins by stimulated neutrophils

1987 • 111 citations

DNA-ferrous iron catalyzed hydroxyl free radical formation from hydrogen peroxide

1981 • 108 citations

Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes.

1986 • 106 citations

The role of superoxide and hydroxyl radicals in the degradation of DNA and deoxyribose induced by a copperphenanthroline complex

1982 • 104 citations

On the Use of OH · Scavengers in Biological Systems

1984 • 100 citations

Hydroxyl radical production by stimulated neutrophils reappraised.

1988 • 100 citations

Iron mediates paraquat toxicity in Escherichia coli.

1986 • 83 citations

Induction of 5,6-ring-saturated thymine bases in NIH-3T3 cells by phorbol ester-stimulated macrophages: role of reactive oxygen intermediates.

1985 • 82 citations

Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.

1988 • 77 citations

Formation of long-lived hydroxyl free radical adducts of proline and hydroxyproline in a fenton reaction

1984 • 75 citations

Mixed-function oxidation of histidine residues

1984 • 70 citations

Intraarticular ferritin‐bound iron in rheumatoid arthritis: A factor that increases oxygen free radical‐induced tissue destruction

1986 • 68 citations

The Respiratory Burst and Its Physiological Significance

1988 • 66 citations

Fluorescent light-induced chromosome damage in human IMR-90 fibroblasts role of hydrogen peroxide and related free radicals

1980 • 59 citations

The generation of hydroxyl radicals following superoxide production by neutrophil NADPH oxidase

1982 • 54 citations

Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate

1982 • 52 citations

Rapid induction of IgM-secreting murine plasmacytomas by pristane and an immunoglobulin heavy-chain promoter/enhancer-driven c-myc/v-Ha-ras retrovirus.

1988 • 46 citations

Ascorbate/iron mediation of hydroxyl free radical damage to PBR322 plasmid DNA

1988 • 43 citations

Formation of a Histidine-peroxide Adduct by H₂O₂or Ionizing Radiation on Histidine: Chemical and Microbiological Properties

1969 • 41 citations

Phagocytes, O2 Reduction, and Hydroxyl Radical

1988 • 40 citations

SISTER CHROMATID EXCHANGES AND CHROMOSOME ABERRATIONS IN HUMAN CELLS INDUCED BY H₂O₂ AND OTHER PHOTOPRODUCTS GENERATED IN FLUORESCENT LIGHT‐EXPOSED MEDIUM

1984 • 38 citations

Indirect induction of a clastogenic effect in epidermal cells by a tumor promoter

1985 • 37 citations

Quantitation of single- and double-strand DNA breaks in vitro and in vivo

1986 • 37 citations

Serum-free medium for growth factor-dependent and -independent plasmacytomas and hybridomas

1987 • 37 citations

Clastogenic action of tumor promoter phorbol-12-myristate-13 acetate in mixed human leukocyte cultures

1983 • 36 citations

Fever, Hypotension, and Pulmonary Infiltrates in a Young Haitian Man

1988 • 15 citations

Oxidation of nitroxide radicals by an iron‐hydrogen peroxide‐amino acid system

1985 • 7 citations