The Respiratory Burst and Carcinogenesis

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

1975 • 3,362 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

β-Carotene: an Unusual Type of Lipid Antioxidant

1984 • 2,147 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

The respiratory burst of phagocytes.

1984 • 914 citations

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

1976 • 850 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens.

1982 • 747 citations

The Incidence of Adenocarcinoma in Columnar-Lined (Barrett's) Esophagus

1985 • 736 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

The Sequential Analysis of Cancer Development

1980 • 613 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

TEXTBOOK OF MEDICINE

1976 • 521 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.

1984 • 520 citations

The stages of initiation and promotion in hepatocarcinogenesis

1980 • 515 citations

Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound

1981 • 510 citations

Cellular Pathology As Based upon Physiological and Pathological Histology.

1972 • 460 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Tumor Promoters and the Mechanism of Tumor Promotion

1980 • 415 citations

Free Radicals in Medicine. I. Chemical Nature and Biologic Reactions

1988 • 398 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

The Cocarcinogenic Action of Croton Resin

1941 • 386 citations

Specific binding of phorbol ester tumor promoters

1980 • 364 citations

Colon Cancer, Dysplasia, and Surveillance in Patients with Ulcerative Colitis

1987 • 341 citations

The Pathogenesis of Asbestos-Associated Diseases

1982 • 335 citations

Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.

1986 • 314 citations

Oxygen, ischemia and inflammation.

1986 • 313 citations

Carcinogenesis—A Comprehensive survey

1982 • 311 citations

Mutagenic activity of tumor-associated macrophages in Salmonella typhimurium strains TA98 and TA 100.

1984 • 302 citations

Interaction of Oxygen and Oxy-radicals With Carotenoids<xref ref-type="fn" rid="FN1">1</xref>

1982 • 300 citations

The Role of Oxygen Radicals as a Possible Mechanism of Tumor Promotion

1985 • 282 citations

Role of superoxide in deoxyribonucleic acid strand scission

1980 • 276 citations

Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters

1980 • 274 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury.

1985 • 268 citations

Mutation Caused by Human Phagocytes

1981 • 264 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.

1981 • 260 citations

Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase

1983 • 256 citations

DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate

1982 • 255 citations

THE INITIATING AND PROMOTING ELEMENTS IN TUMOR PRODUCTION

1944 • 251 citations

Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1982 • 237 citations

Wounding and Its Role in RSV-Mediated Tumor Formation

1985 • 225 citations

Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis

1981 • 220 citations

Anticarcinogenesis and Radiation Protection

1987 • 210 citations

Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.

1984 • 208 citations

Incidence of Squamous Cell Carcinoma in Patients With Long-term Catheter Drainage

1985 • 206 citations

Free radicals in tumor promotion

1986 • 198 citations

Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradeconylphorbolacetate

1986 • 192 citations

Studies on the mechanism of skin tumor promotion.

1970 • 187 citations

Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms.

1986 • 183 citations

Biochemical aspects of phagocytosis in poly-morphonuclear leucocytes. NADH and NADPH oxidation by the granules of resting and phagocytizing cells

1964 • 182 citations

Evidence for reactive oxygen species inducing mutations in mammalian cells.

1986 • 175 citations

Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages.

1986 • 175 citations

Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry.

1986 • 171 citations

Persons at High Risk of Cancer. An Approach to Cancer Etiology and Control

1976 • 164 citations

Metabolism of Polycyclic Aromatic Hydrocarbon Derivatives to Ultimate Carcinogens During Lipid Peroxidation

1983 • 162 citations

Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.

1985 • 162 citations

Rat Model for Carcinogenesis in Ureterosigmoidostomy

1980 • 160 citations

Generation of nitrogen-chlorine oxidants by human phagocytes.

1984 • 156 citations

Malignancy in scars, chronic ulcers, and sinuses

1963 • 154 citations

Protease inhibitors antagonize the activation of polymorphonuclear leukocyte oxygen consumption

1979 • 150 citations

Associated bilharziosis and primary malignant disease of the urinary bladder, with observations on a series of forty cases

1911 • 149 citations

Effects of antioxidants on oxidant-induced sister chromatid exchange formation.

1985 • 146 citations

Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide.

1986 • 144 citations

Oxidant injury of cells.

1987 • 135 citations

Modifiers of free radicals inhibit in vitro the oncogenic actions of x-rays, bleomycin, and the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.

1983 • 126 citations

The production of DNA strand breaks in human leukocytes by superoxide anion may involve a metabolic process.

1985 • 124 citations

Barrett's esophagus in children: A consequence of chronic gastroesophageal reflux

1984 • 121 citations

Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer.

1985 • 119 citations

Formation of 8-hydroxyguanine residues in DNA by X-irradiation.

1984 • 117 citations

Lung Cancer Mortality Among U.S. Uranium Miners: A Reappraisal<xref ref-type="fn" rid="FN2">2</xref>

1983 • 116 citations

Activation of the respiratory burst oxidase in a fully soluble system from human neutrophils.

1987 • 111 citations

Prostaglandin E-mediated mitogenic stimulation of mouse epidermis in vivo by divalent cation ionophore A 23187 and by tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1981 • 110 citations

Singlet Oxygen Formation Detected by Low-Level Chemiluminescence during Enzymatic Reduction of Prostaglandin G₂to H₂

1983 • 109 citations

Functional relationship of the cytochrome b to the superoxide-generating oxidase of human neutrophils.

1982 • 109 citations

Chemical Carcinogenesis

1981 • 108 citations

Persons at high risk of cancer. An approach to cancer etiology and control

1977 • 106 citations

Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes.

1986 • 106 citations

Promotion of carcinomas by repeated abrasion in initiated skin of mice.

1981 • 103 citations

DNA damage induced by asbestos in the presence of hydrogen peroxide.

1984 • 103 citations

Inhibitory effects of glutathione level-raising agents and D-α-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

1985 • 102 citations

Squamous cell carcinoma arising in dissecting perifolliculitis of the scalp

1981 • 99 citations

Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.

1985 • 98 citations

Hydrogen peroxide formation and DNA base modification by tumor promoter-activated polymorphonuclear leukocytes

1987 • 97 citations

Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds

1984 • 96 citations

Retinoid inhibition of superoxide anion radical production by human polymorphonuclear leukocytes stimulated with tumor promoters

1980 • 95 citations

Stimulated DNA synthesis in mouse epidermal cell cultures treated with 12-O-tetradecanoyl-phorbol-13-acetate.

1976 • 94 citations

Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate.

1983 • 93 citations

Carcinoma of the intestinal tract in Crohn's disease: results of a survey conducted by the National Foundation for Ileitis and colitis.

1983 • 93 citations

Tumor promotion and the induction of epidermal ornithine decarboxylase activity in mechanically stimulated mouse skin.

1978 • 90 citations

Are free radicals involved in tumor promotion?

1985 • 85 citations

Induction of 5,6-ring-saturated thymine bases in NIH-3T3 cells by phorbol ester-stimulated macrophages: role of reactive oxygen intermediates.

1985 • 82 citations

Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line.

1986 • 80 citations

Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.

1984 • 76 citations

III. Carcinomatous Changes in an Area of Chronic Ulceration, or Marjolin's Ulcer.

1903 • 74 citations

Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.

1986 • 73 citations

BROWN-SÉQUARD

1952 • 71 citations

Relation of human neutrophil phorbol ester receptor occupancy and NADPH- oxidase activity

1982 • 69 citations

cDNA cloning of human myeloperoxidase: decrease in myeloperoxidase mRNA upon induction of HL-60 cells.

1987 • 69 citations

The oxidative killing mechanisms of the neutrophil.

1977 • 67 citations

Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolism

1986 • 67 citations

The natural history of neoplastic development:The relation of experimental models to human cancer

1982 • 67 citations

Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin

1985 • 67 citations

Similar effects of phospholipase C and phorbol ester tumor promoters on primary mouse epidermal cells.

1985 • 63 citations

Effect of the urine and calculus formation on the incidence of bladder tumors in rats implanted with paraffin wax pellets

1974 • 63 citations

Carcinoma arising in the scars of thermal burns, with special reference to the influence of the age at burn on the length of the induction period.

1952 • 61 citations

Effects of anti-promoters and strain of mouse on tumor promoter-induced oxidants in murine epidermal cells

1986 • 59 citations

Phagocytosis-induced mutagenesis in bacteria

1983 • 58 citations

Tumor-Promoting Properties of Anthralin (1,8,9-Anthratriol)<xref ref-type="fn" rid="fn1">2</xref>

1963 • 57 citations

Colonic neoplasms complicating ureterosigmoidostomy

1975 • 55 citations

Inflammation: the role of peroxidase-derived products.

1980 • 54 citations

Carcinoma of the lung complicating lipoid pneumonia

1983 • 53 citations

On the role of superoxide anion radicals in skin tumour promotion

1984 • 53 citations

Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate

1982 • 52 citations

The induction of ornithine decarboxylase by phorbol 12-myristate 13-acetate or by serum is inhibited by antioxidants

1983 • 49 citations

Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters

1986 • 47 citations

JOINT ACTION OF A CHEMICAL CARCINOGEN AND A NEOPLASTIC VIRUS TO INDUCE CANCER IN RABBITS

1951 • 46 citations

Tumorigenesis at a Predetermined Oral Site After One Intraperitoneal Injection of N -Nitroso- N -Methylurea

1982 • 42 citations

Effects of hay‐feeding on acid/base balance, renal sodium excretion, aldosterone and vasopressin secretion in the goat

1986 • 42 citations

Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation

1986 • 37 citations

Icosanoids and Cancer

1984 • 37 citations

Investigation of a possible role for superoxide anion production in tumour promotion

1983 • 35 citations

Possible role of oxygen radicals in cell transformation by diethylstilbestrol and related compounds

1986 • 34 citations

Role of Inflammation in Carcinogenesis

1960 • 33 citations

Phagocyte-induced mutation in Chinese hamster ovary cells

1984 • 32 citations

Cellular pathology as based upon physiological and pathological histology : twenty lectures delivered in the Pathological Institute of Berlin

1860 • 30 citations

Cases of Warty Tumours in Cicatrices

1835 • 30 citations

Tumor promotion by regenerative epidermal hyperplasia in mouse skin

1982 • 29 citations

Carcinoma in Skin, Sinuses and Bone Following Chronic Osteomyelitis

1957 • 29 citations

Phorbol ester-induced formation of clastogenic factor from human monocytes

1987 • 24 citations

TRAUMA AND SQUAMOUS SKIN CANCER

1959 • 23 citations

Arachidonic Acid Metabolism and Tumor Initiation

1985 • 22 citations

Ureterosigmoidostomy and Colon Carcinogenesis

1981 • 22 citations

Properties of incomplete carcinogens and promoters in hepatocarcinogenesis.

1982 • 22 citations

Tumor Promotion in Skin: Are Active Oxygen Species Involved?

1985 • 15 citations

Phorbol diacetate inhibits superoxide anion radical production and tumor promotion by mezerein

1986 • 14 citations

Failure of Phorbol Myristate Acetate to Damage DNA in Leukocytes from Patients with Chronic Granulomatous Disease

1982 • 13 citations

An examination of the DNA damaging and repair inhibitory capacity of phorbol myristate acetate in human diploid fibroblasts

1985 • 12 citations

N -[4-(5-Nitro-2-Furyl)-2-Thiazolyl] Formamide-Induced Bladder Cancer in Mice: Augmentation by Sutures Through the Bladder Wall

1987 • 12 citations

Phospholipase C minics tumor promoter-induced chemiluminescence in murine epidermal cells

1985 • 12 citations

Free Radicals in Medicine. I. Chemical Nature and Biologic Reactions. II. Involvement in Human Disease

1988 • 11 citations

Mechanisms of Inactivation of Oxygen Species by Carotenoids

1987 • 9 citations

Chemicals and Cancer: Initiation and Promotion

1983 • 8 citations

Activation of Xenobiotics by Human Polymorphonuclear Leukocytes via Reactive Oxygen-Dependent Reactions

1986 • 7 citations

Dietary Choline Deficiency as a New Model to Study the Possible Role of Free Radicals in Acute Cell Injury and in Carcinogenesis

1987 • 4 citations