Leptin Resistance of Adipocytes in Obesity: Role of Suppressors of Cytokine Signaling

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

1994 • 813 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance

1999 • 640 citations

Novel Form of Lipolysis Induced by Leptin

1999 • 362 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

Insulin within islets is a physiologic glucagon release inhibitor.

1984 • 299 citations

Reversing adipocyte differentiation: Implications for treatment of obesity

1999 • 232 citations

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

1998 • 177 citations

Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia

1981 • 102 citations

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

1998 • 99 citations

Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia

1999 • 86 citations