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Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis

Data up to Jan 2025

Published1993
Citations111
References35

Total Citations Per Year

Abstract

References (35)

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Immunologic Functions of Ia-Bearing Epidermal Langerhans Cells

1978 • 732 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

1991 • 526 citations

Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity.

1982 • 481 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

1993 • 427 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.

1992 • 327 citations

Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum.

1985 • 306 citations

The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes.

1985 • 258 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

Parasitism of Epidermal Langerhans Cells in Experimental Cutaneous Leishmaniasis withLeishmania major

1993 • 153 citations

Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells.

1990 • 144 citations

Regulation of T helper cell cytokine expression: functional dichotomy of antigen‐presenting cells

1993 • 136 citations

Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV

1991 • 129 citations

Functional Dichotomy between Langerhans Cells that Present Antigen to Naive and to Memory/Effector T Lymphocytes

1990 • 104 citations

Anisakiasis — Is the sushi bar guilty?

1987 • 101 citations

Distribution and turnover of Langerhans cells during delayed immune responses in human skin.

1987 • 89 citations

Immunopathology of experimental cutaneous leishmaniasis.

1984 • 88 citations

Lymphocytes play the music but the macrophage calls the tune

1991 • 77 citations

Resistance to murine cutaneous leishmaniasis is mediated by TH1 cells, but disease‐promoting CD4+ cells are different from TH2 cells

1990 • 69 citations

The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment

1989 • 65 citations

Exacerbation of experimental murine cutaneous leishmaniasis with CD4+Leishmania major‐specific T cell lines or clones which secrete interferon‐γ and mediate parasite‐specific delayed‐type hypersensitivity

1991 • 57 citations

Murine epidermal Langerhans cells are potent stimulators of an antigen‐specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis

1992 • 47 citations

Dendritic Cells in Fundamental and Clinical Immunology

1993 • 39 citations

Effect of Local Ultraviolet Irradiation on Infections of Mice with Candida albicans, Mycobacterium bovis BCG, and Schistosoma mansoni

1992 • 35 citations

Interleukin-1 decreases the number of Ia+ epidermal dendritic cells but increases their expression of Ia antigen.

1990 • 32 citations

The involvement of dendritic cells in the cutaneous lesions associated with tuberculoid and lepromatous leprosy.

1985 • 32 citations

Epidermal Compromise in American Cutaneous Leishmaniasis

1992 • 25 citations

Effects of ultraviolet B irradiation on cutaneous leishmaniasis

1992 • 24 citations

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