Amino Acid Residues in both the DNA-Binding and Ligand-Binding Domains Influence Transcriptional Activity of the Human Peroxisome Proliferator-Activated Receptor Alpha

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Current Protocols in Molecular Biology

2001 • 2,451 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 • 1,201 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

1993 • 523 citations

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.

1995 • 398 citations

Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.

1995 • 342 citations

Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis

1994 • 318 citations

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

1994 • 273 citations

Hepatic peroxisome proliferation in rodents and its significance for humans

1993 • 271 citations

Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.

1994 • 246 citations

AF-2 Activity and Recruitment of Steroid Receptor Coactivator 1 to the Estrogen Receptor Depend on a Lysine Residue Conserved in Nuclear Receptors

1997 • 214 citations

A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs

1996 • 202 citations

The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor

1993 • 119 citations

Identification of Amino Acids in the Hormone Binding Domain of the Human Estrogen Receptor Important in Estrogen Binding

1996 • 110 citations

Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term gemfibrozil treatment

1982 • 105 citations

Thyroid Hormone Receptor Mutations that Interfere with Transcriptional Activation also Interfere with Receptor Interaction with a Nuclear Protein

1991 • 93 citations

The effect of beclobric acid and clofibric acid on peroxisomal β-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes

1990 • 89 citations

Peroxisomes : biology and role in toxicology and disease

1996 • 70 citations

Genetic dissection of thyroid hormone receptor β: identification of mutations that separate hormone binding and transcriptional activation

1995 • 34 citations

Peroxisome proliferation and beta-oxidation in Fao and MH1C1 rat hepatoma cells, HepG2 human hepatoblastoma cells and cultured human hepatocytes: effect of ciprofibrate.

1997 • 34 citations

Comparative Toxicology of Hypolipidaemic Fibrates

1996 • 29 citations

Second Zinc Finger Mutants of Thyroid Hormone Receptor Selectively Preserve DNA Binding and Heterodimerization but Eliminate Transcriptional Activation

1996 • 15 citations