The effect of beclobric acid and clofibric acid on peroxisomal β-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes

THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

1963 • 24,942 citations

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

1976 • 1,136 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man

1981 • 233 citations

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

1982 • 223 citations

The carcinogenicity of dietary di(2‐ethylhexyl) phthalate (DEHP) in fischer 344 rats and B6C3F₁mice

1982 • 219 citations

Peroxisome proliferation in primary cultures of rat hepatocytes

1983 • 178 citations

Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver

1988 • 162 citations

Induction of hepatic peroxisome proliferation in nonrodent species, including primates.

1984 • 137 citations

Relationship between morphological changes and lipid-lowering action of -chlorphenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man

1983 • 135 citations

Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term gemfibrozil treatment

1982 • 105 citations

Comparative studies on di-(2-ethylhexyl) phthalate-induced hepatic peroxisome proliferation in the rat and hamster

1984 • 100 citations

Factors influencing peroxisome proliferation in cultured rat hepatocytes

1984 • 99 citations

Cryopreservation of adult human hepatocytes

1986 • 97 citations

Differential induction and regulation of peroxisomal enzymes: Predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens

1989 • 86 citations

In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F₁ mice to hepatic peroxisome proliferators

1986 • 75 citations

Effects of the hepatocarcinogen nafenopin, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital.

1985 • 72 citations

Clobuzarit: Species differences in the morphological and biochemical response of the liver following chronic administration

1984 • 56 citations

Application of automatic image analysis for morphometric studies of peroxisomes stained cytochemically for catalase

1986 • 48 citations

The effect of feeding fish oils, vegetable oils and clofibrate on the ketogenesis from long chain fatty acids in hepatocytes

1986 • 42 citations

ANALYTICAL SUBCELLULAR FRACTIONATION AND ENZYMIC ANALYSIS OF LIVER HOMOGENATES FROM CONTROL AND CLOFIBRATE‐TREATED RATS, MICE, AND MONKEYS WITH REFERENCE TO THE FATTY ACID‐OXIDIZING ENZYMES

1982 • 23 citations

Increased 4‐enoyl‐CoA reductase activity in liver mitochondria of rats fed high‐fat diets and its effect on fatty acid oxidation and the inhibitory action of pent‐4‐enoate

1980 • 21 citations

SPECIES DIFFERENCES IN THE EFFECTS OF ICI 55,897 ON PLASMA LIPIDS AND HEPATIC PEROXISOMES

1982 • 13 citations

Induction and activity of several isoenzymes of cytochrome P-450 in primary cultures of rat hepatocytes, in comparison with in vivo data.

1987 • 11 citations

Induction of peroxisomal fatty acyl-CoA oxidase and microsomal laurate hydroxylase activities by beclobric acid and two metabolites in primary cultures of rat hepatocytes

1987 • 9 citations

Mitogenicity of peroxisome proliferators in monolayers of adult rat hepatocytes

1986 • 7 citations

Pharmacological studies with beclobrate, a new hypolipidemic agent.

1983 • 3 citations