LOCALIZATION OF HUMAN INTERLEUKIN 13 RECEPTOR IN NON-HAEMATOPOIETIC CELLS

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2–dominated inflammatory response

1999 • 601 citations

Genetic variants of IL-13 signalling and human asthma and atopy

2000 • 427 citations

IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells.

1995 • 424 citations

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

1996 • 406 citations

Impaired Development of Th2 Cells in IL-13-Deficient Mice

1998 • 384 citations

In vivo expression of IL-12 and IL-13 in atopic dermatitis

1996 • 380 citations

IL-13 expression at the sites of allergen challenge in patients with asthma.

1995 • 373 citations

Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses

1999 • 352 citations

Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells.

1997 • 347 citations

The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1.

1998 • 324 citations

Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma

1997 • 321 citations

cDNA Cloning and Characterization of the Human Interleukin 13 Receptor α Chain

1996 • 285 citations

A Critical Role for IL-13 in Resistance to Intestinal Nematode Infection

1998 • 284 citations

Cloning and Characterization of a Specific Interleukin (IL)-13 Binding Protein Structurally Related to the IL-5 Receptor α Chain

1996 • 278 citations

Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy.

1997 • 275 citations

Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy

2000 • 267 citations

The Murine IL-13 Receptor α2: Molecular Cloning, Characterization, and Comparison with Murine IL-13 Receptor α1

1998 • 262 citations

Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling.

1999 • 249 citations

IL-13 Is a Key Regulatory Cytokine for Th2 Cell-Mediated Pulmonary Granuloma Formation and IgE Responses Induced bySchistosoma mansoniEggs

1999 • 216 citations

Differences Between IL-4- and IL-4 Receptor α-Deficient Mice in Chronic Leishmaniasis Reveal a Protective Role for IL-13 Receptor Signaling

1999 • 204 citations

IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts

1998 • 186 citations

T Cells and T Cell-Derived Cytokines as Pathogenic Factors in the Nonallergic Form of Atopic Dermatitis

1999 • 177 citations

Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis.

1995 • 124 citations

Regulation of endothelial and mesothelial cell function by interleukin- 13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production

1994 • 116 citations

Interleukin-13 and interleukin-4 are coexpressed in atopic asthma.

1996 • 113 citations

A novel 4‐kb interleukin‐13 receptor α mRNA expressed in human B, T, and endothelial cells encoding an alternate type‐II interleukin‐4/ interleukin‐13 receptor

1997 • 106 citations

Cytokine profiles of BAL T cells and T‐cell clones obtained from human asthmatic airways after local allergen challenge

1999 • 103 citations

Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients

1996 • 102 citations

IL-13 in allergy: home at last

1999 • 96 citations

IL-13 mRNA and Immunoreactivity in Allergen-induced Rhinitis: Comparison with IL-4 Expression and Modulation by Topical Glucocorticoid Therapy

1997 • 90 citations

Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)

1997 • 79 citations

Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor α chain 1: redundancy of requirement of tyrosine residue for STAT3 activation

2000 • 71 citations

The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes.

1997 • 65 citations

Interleukin‐13 stimulates interleukin‐6 production by human keratinocytes

1994 • 63 citations

INTERLEUKIN 4 RECEPTORS ON HUMAN BRONCHIAL EPITHELIAL CELLS. AN IN VIVO AND IN VITRO ANALYSIS OF EXPRESSION AND FUNCTION

1998 • 48 citations

Environmental antigen-induced IL-13 responses are elevated among subjects with allergic rhinitis, are independent of IL-4, and are inhibited by endogenous IFN-gamma synthesis.

1998 • 38 citations

Lesional psoriatic T cells contain the capacity to induce a T cell activation molecule CDw60 on normal keratinocytes.

1997 • 30 citations

Environmental Antigen-Induced IL-13 Responses Are Elevated Among Subjects with Allergic Rhinitis, Are Independent of IL-4, and Are Inhibited by Endogenous IFN-γ Synthesis

1998 • 29 citations

IL-13 over-expression in skin is not confined to IgE-mediated skin inflammation

1997 • 25 citations

Recent Advances in Understanding How Interleukin 13 Signals are Involved in the Pathogenesis of Bronchial Asthma

2001 • 24 citations

Characterization of Cytokine mRNA Transcripts in Conjunctival Cells from Patients with Allergic Conjunctivitis

1995 • 22 citations

lnterleukin-13 Is an Endothelial Chemotaxin

1997 • 21 citations

The potential role of interleukin‐13 in eosinophilic inflammation in nasal mucosa

1998 • 18 citations