Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats

Interleukin-10

1993 • 1,820 citations

Sickness behavior as a new target for drug development

1992 • 866 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Biological properties of interleukin 10

1992 • 656 citations

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

1995 • 537 citations

Proinflammatory and Anti-inflammatory Cytokines as Mediators in the Pathogenesis of Septic Shock

1997 • 507 citations

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

1994 • 502 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide

1998 • 323 citations

Studies with IL-10-/- mice: an overview

1997 • 308 citations

Interleukin‐10 controls interferon‐γ and tumor necrosis factor production during experimental endotoxemia

1994 • 306 citations

Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

1992 • 299 citations

Altered Immune Responses in Interleukin 10 Transgenic Mice

1997 • 279 citations

Induction of tumor necrosis factor-α mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6

1993 • 262 citations

Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue

1997 • 255 citations

Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration.

1994 • 228 citations

Interleukin-10: Biology, Role in Inflammation and Autoimmunity

1997 • 226 citations

Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings.

1997 • 206 citations

Mechanisms of sickness-induced decreases in food-motivated behavior

1996 • 184 citations

Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas.

1995 • 178 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

Regulation of microglial activation by TGF-β, IL-10, and CSF-1

1996 • 150 citations

Production of Interleukin-10 by Mouse Glial Cells in Culture

1994 • 145 citations

Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep

1995 • 139 citations

Gene expression of IL-10 in relationship to TNF-α, IL-1β and IL-2 in the rat brain following middle cerebral artery occlusion

1997 • 126 citations

IL-10 PRODUCTION BY ADULT HUMAN DERIVED MICROGLIAL CELLS

1996 • 92 citations

Circulating interleukin 1 and tumor necrosis factor during inflammation

1987 • 87 citations

Time course and cellular localization of interleukin-10 mRNA and protein expression in autoimmune inflammation of the rat central nervous system.

1998 • 76 citations

High IL-6 and Low IL-10 in the Central Nervous System Are Associated with Protracted Relapsing EAE in DA Rats

1997 • 75 citations

Anti-inflammatory cytokine levels in patients with septic shock.

1997 • 71 citations

Opposite regulation of prostaglandin E2 synthesis by transforming growth factor-β1 and interleukin 10 in activated microglial cultures

1998 • 71 citations

Antigen Presentation in the Central Nervous System

1999 • 62 citations

Endotoxin and staphylococcus aureus enterotoxin a induce different patterns of cytokines

1992 • 60 citations

Effects of interleukin-10 on water intake, locomotory activity, and rectal temperature in rat treated with endotoxin

1997 • 57 citations

Cytokines in the Nervous System

1996 • 55 citations

lnterleukin-10 Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor and Interleukin-1β Production in the Brain without Affecting the Activation of the Hypothalamus-Pituitary-Adrenal Axis

1995 • 52 citations

Systemic interleukin 10 administration inhibits brain tumor necrosis factor production in mice

1997 • 26 citations

Le rétrocontrôle négatif de l'inflammation: rôle des cytokines antiinflammatoires

1997 • 6 citations