Aberrant expression of interleukin-7 (IL-7) and its signalling complex in human breast cancer

STATs in oncogenesis

2000 • 1,723 citations

LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan

1999 • 1,519 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Detection of PCR products using self-probing amplicons and fluorescence

1999 • 699 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis.

1997 • 496 citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

1992 • 450 citations

Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C

1998 • 404 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

1995 • 376 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

2001 • 360 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Confirmation of a prognostic index in primary breast cancer

1987 • 311 citations

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

1996 • 232 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.

1997 • 189 citations

Constitutive Activation of Stat 3 Oncogene Product in Human Ovarian Carcinoma Cells

2000 • 188 citations

STAT proteins as novel targets for cancer therapy

1999 • 180 citations

Interleukin-7 is a growth factor for Sézary lymphoma cells.

1992 • 167 citations

IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line.

1991 • 166 citations

Activation of Signal Transducer and Activator of Transcription 3 in Renal Cell Carcinoma: A Study of Incidence and Its Association With Pathological Features and Clinical Outcome

2002 • 164 citations

Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia

1990 • 158 citations

Molecular Prognostic Markers in Pancreatic Cancer

2000 • 154 citations

Stat3 activation in prostatic carcinomas

2002 • 139 citations

Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

1995 • 127 citations

ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells

1999 • 122 citations

Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-?

2000 • 106 citations

Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells

2001 • 106 citations

Tumor cells cotransfected with interleukin‐7 and B7.1 genes induce CD25 and CD28 on tumor‐infiltrating T lymphocytes and are strong vaccines

1995 • 85 citations

Human interleukin-7 induces proliferation of neoplastic cells from chronic lymphocytic leukemia and acute leukemias

1991 • 78 citations

JAK3 Janus kinase is involved in interleukin 7 signal pathway

1994 • 67 citations

Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia.

1993 • 65 citations

Interleukin‐7 (IL‐7) in Colorectal Cancer: IL‐7 is Produced by Tissues from Colorectal Cancer and Promotes Preferential Expansion of Tumour Infiltrating Lymphocytes

1997 • 65 citations

Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines

2002 • 64 citations

Frequent expression of IL-7 gene transcripts in tumor cells of classical Hodgkin's disease.

1995 • 63 citations

Cytokine mRNA Expression Patterns in Human Esophageal Cancer Cell Lines

1995 • 63 citations

Protein kinases in human breast cancer

1995 • 60 citations

Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity

1994 • 46 citations

Constitutive and IFN-gamma regulated expression of IL-7 and IL-15 in human renal cell cancer.

1999 • 45 citations

In vitro culture of common acute lymphoblastic leukemia blasts: effects of interleukin-3, interleukin-7, and accessory cells

1992 • 44 citations

Lymphangiogenesis Quantification Using Quantitative PCR and Breast Cancer as a Model

2001 • 42 citations

γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors

1995 • 38 citations

Hierarchical Immunosuppression of Regional Lymph Nodes in Patients with Head and Neck Squamous Cell Carcinoma

1991 • 37 citations

Natural killer activity and serum immunosuppressive acidic protein levels in esophageal and gastric cancers

1993 • 33 citations

Spontaneous Production of lnterleukin-8 by Human Lung Cancer Cells and Its Augmentation by Tumor Necrosis Factor Alpha and lnterleukin-1 at Protein and mRNA Levels

1994 • 26 citations

Interleukins 7 and 12 are expressed in head and neck squamous cancer

2001 • 24 citations

T-Cell Reconstitution by Molecular, Phenotypic, and Functional Analysis in the Thymus, Bone Marrow, Spleen, and Blood Following Split-Dose Polychemotherapy and Therapeutic Activity for Metastatic Breast Cancer in Mice

1993 • 13 citations

Deleted Work

1955 • 0 citations