Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

1979 • 424 citations

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter

1987 • 407 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Expression of the c-myb proto-oncogene during cellular proliferation

1986 • 360 citations

Interleukin-15 protects from lethal apoptosis in vivo

1997 • 339 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

IL-15 and IL-2: a matter of life and death for T cells in vivo

2001 • 316 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1997 • 278 citations

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

1996 • 232 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

A dominant interfering Myb mutant causes apoptosis in T cells.

1996 • 191 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

Apoptosis and the maintenance of homoeostasis in the immune system

1996 • 178 citations

Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.

1986 • 174 citations

v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells.

1996 • 173 citations

Sezary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain)

1996 • 172 citations

Interleukin-7 is a growth factor for Sézary lymphoma cells.

1992 • 167 citations

Interleukin-15 Is an Autocrine/Paracrine Viability Factor for Cutaneous T-Cell Lymphoma Cells

1998 • 162 citations

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

2001 • 131 citations

Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene.

1991 • 130 citations

Interleukin-15 mRNA Is Expressed by Human Keratinocytes, Langerhans Cells, and Blood-Derived Dendritic Cells and Is Downregulated by Ultraviolet B Radiation

1996 • 129 citations

Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice.

1993 • 126 citations

Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation ofbcl-2 promoter activity

1997 • 110 citations

Ultraviolet B radiation up-regulates the expression of IL-15 in human skin.

1995 • 104 citations

Expression of bcl‐2 protein and Ki‐67 nuclear proliferation antigen in benign and malignant cutaneous T‐cell infiltrates

1995 • 91 citations

Activation of Stat5 by interleukin 2 requires a carboxy-terminal region β chain but is not exxential for the proliferative signal transdution.

1995 • 87 citations

Cutaneous lymphomas

1997 • 66 citations

Constitutive and Interleukin-7/Interleukin-15 Stimulated DNA Binding of Myc, Jun, and Novel Myc-Like Proteins in Cutaneous T-Cell Lymphoma Cells

1999 • 54 citations

Mycosis fungoides: Expression of C-myc p62 p53, bcl-2and PCNA Proteins and Absence of Association with Epstein-Barr Virus

1994 • 53 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interlekin 2 receptor βchain but is not essential for the proliferative signal transmission.

1995 • 48 citations

bcl-1, bcl-2, p53, c-myc, and lyt-10 Analysis in Cutaneous Lymphomas

1995 • 33 citations

Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma cells by both suppressing the CPP32-like protease activation and inducing the Bcl-2 expression.

1996 • 27 citations

In vitrotranscription complementation assay with miniextracts of transiently transfected COS-1 cells

1992 • 13 citations

Constitutive and Interleukin-7/Interleukin-15 Stimulated DNA Binding of Myc, Jun, and Novel Myc-Like Proteins in Cutaneous T-Cell Lymphoma Cells

1999 • 3 citations