Molecular characterization of Arabidopsis PHO80-like proteins, a novel class of CDKA;1-interacting cyclins

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

BIOEDIT: A USER-FRIENDLY BIOLOGICAL SEQUENCE ALIGNMENT EDITOR AND ANALYSIS PROGRAM FOR WINDOWS 95/98/ NT

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Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Fitting a mixture model by expectation maximization to discover motifs in biopolymers.

1994 • 4,818 citations

Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)

2009 • 3,831 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing

2002 • 2,565 citations

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Clinician’s Guide to Cardiopulmonary Exercise Testing in Adults

2010 • 1,680 citations

Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes

1984 • 1,638 citations

An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea

2012 • 1,553 citations

Unravelling angiosperm genome evolution by phylogenetic analysis of chromosomal duplication events

2003 • 1,538 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

The role of nutrient availability in regulating root architecture

2003 • 1,395 citations

SMART: a web-based tool for the study of genetically mobile domains

2000 • 1,298 citations

Phosphate Availability Regulates Root System Architecture in Arabidopsis

2001 • 720 citations

A Recent Polyploidy Superimposed on Older Large-Scale Duplications in the Arabidopsis Genome

2003 • 694 citations

Microarray Analysis of the Nitrate Response in Arabidopsis Roots and Shoots Reveals over 1,000 Rapidly Responding Genes and New Linkages to Glucose, Trehalose-6-Phosphate, Iron, and Sulfate Metabolism

2003 • 647 citations

D-dimer antigen: current concepts and future prospects

2008 • 604 citations

Genome-Wide Analysis of Core Cell Cycle Genes in Arabidopsis

2002 • 586 citations

The hidden duplication past of Arabidopsis thaliana

2002 • 498 citations

Pathophysiology of Dyspnea

1995 • 470 citations

cdc2a expression in Arabidopsis is linked with competence for cell division.

1993 • 452 citations

Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease

2005 • 423 citations

Construction of evolutionary distance trees with TREECON for Windows: accounting for variation in nucleotide substitution rate among sites

1997 • 380 citations

Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85

1994 • 361 citations

Acute respiratory failure in the elderly: etiology, emergency diagnosis and prognosis

2006 • 341 citations

The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus

1998 • 336 citations

Transcriptome Profiling of Sulfur-Responsive Genes in Arabidopsis Reveals Global Effects of Sulfur Nutrition on Multiple Metabolic Pathways

2003 • 292 citations

Characterisation of the onset and presenting clinical features of adult bronchiectasis

2006 • 259 citations

Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care

2003 • 254 citations

THE SENSATION OF BREATHLESSNESS

1963 • 251 citations

Cell Cycle-regulated Gene Expression inArabidopsis

2002 • 240 citations

Phosphate-Regulated Inactivation of the Kinase PHO80-PHO85 by the CDK Inhibitor PHO81

1994 • 239 citations

Spatial pattern of cdc2 expression in relation to meristem activity and cell proliferation during plant development.

1992 • 208 citations

Uncovering Heart Failure in Patients with a History of Pulmonary Disease: Rationale for the Early Use of B-type Natriuretic Peptide in the Emergency Department

2003 • 203 citations

Does the Clinical Examination Predict Airflow Limitation?

1995 • 180 citations

Acute Epiglottitis in Adults

1994 • 167 citations

Pho85 and signaling environmental conditions

2002 • 158 citations

Cell Cycle Control by a Complex of the Cyclin HCS26 (PCL1) and the Kinase PHO85

1994 • 152 citations

A Community Population Survey of Prevalence and Severity of Dyspnea in Adults

2009 • 147 citations

The Automatic Detection of Homologous Regions (ADHoRe) and Its Application to Microcolinearity Between Arabidopsis and Rice

2002 • 141 citations

PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae

1988 • 141 citations

A new D-type cyclin of Arabidopsis thaliana expressed during lateral root primordia formation

1999 • 141 citations

Diagnostic Accuracy of a Bedside D-dimer Assay and Alveolar Dead-Space Measurement for Rapid Exclusion of Pulmonary Embolism

2001 • 128 citations

Cyclin Partners Determine Pho85 Protein Kinase Substrate Specificity In Vitro and In Vivo: Control of Glycogen Biosynthesis by Pcl8 and Pcl10

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Breathlessness Induced by Dissociation between Ventilation and Chemical Drive

1989 • 124 citations

The age of the Arabidopsis thaliana genome duplication.

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Conserved structural motifs in cyclins identified by sequence analysis

1991 • 110 citations

The Arabidopsis Cks1At protein binds the cyclin‐dependent kinases Cdc2aAt and Cdc2bAt

1997 • 103 citations

Cross sectional study of contribution of clinical assessment and simple cardiac investigations to diagnosis of left ventricular systolic dysfunction in patients admitted with acute dyspnoea

1997 • 96 citations

Dissection of a Complex Phenotype by Functional Genomics Reveals Roles for the Yeast Cyclin-Dependent Protein Kinase Pho85 in Stress Adaptation and Cell Integrity

2002 • 95 citations

Discriminating causes of dyspnea through clinical examination

1993 • 92 citations

Characterization of two distinct DP‐related genes from Arabidopsis thaliana¹

2000 • 90 citations

Airway obstruction in systolic heart failure – COPD or congestion?

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A PHO80-like Cyclin and a B-type Cyclin Control the Cell Cycle of the Procyclic Form of Trypanosoma brucei

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Phosphate as a Limiting Factor for the Cell Division of Tobacco BY-2 Cells

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Dyspnea: A sensory experience

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Patients with Acute Hyperventilation Presenting to an Inner-City Emergency Department

1996 • 75 citations

Investigating ancient duplication events in the Arabidopsis genome

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Dyspnea. Pathophysiologic basis, clinical presentation, and management

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Evaluation of chronic dyspnea.

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Activation of CDK‐activating kinase is dependent on interaction with H‐type cyclins in plants

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cdc2a Expression in Arabidopsis Is Linked with Competence for Cell Division

1993 • 69 citations

In Situ Hybridization to mRNA of Arabidopsis Tissue Sections

2001 • 66 citations

Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division

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Dissociation of lung function, dyspnea ratings and pulmonary extension in bronchiectasis

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Insertional mutagenesis in Neurospora crassa: cloning and molecular analysis of the preg+ gene controlling the activity of the transcriptional activator NUC-1.

1993 • 59 citations

Strategies Incorporating Spiral CT for the Diagnosis of Acute Pulmonary Embolism

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Accuracy and reliability of physical signs in the diagnosis of pleural effusion

2006 • 57 citations

Causes and evaluation of chronic dyspnea.

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Discriminating Between Cardiac and Pulmonary Dysfunction in the General Population With Dyspnea by Plasma Pro-B-Type Natriuretic Peptide

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Cloning and sequencing of the PHO80 gene and CEN15 of Saccharomyces cerevisiae

1986 • 51 citations

Isolation of Trypanosoma brucei CYC2 andCYC3 Cyclin Genes by Rescue of a Yeast G1Cyclin Mutant

2000 • 50 citations

A Genetic Study of Signaling Processes for Repression of PHO5 Transcription in Saccharomyces cerevisiae

1998 • 49 citations

A Detailed Evaluation of Patients With Acute Pulmonary Embolism and Low- or Very-Low-Probability Lung Scan Interpretations

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ForCon : a software tool for the conversion of sequence alignments

1999 • 38 citations

Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins

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Acute dyspnea in the office.

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Evaluation of the Dyspneic Patient in the Office

2006 • 32 citations

EVALUATION OF DYSPNEA IN THE ELDERLY PATIENT

1993 • 30 citations

Dyspnea

2006 • 29 citations

The acute asthmatic patient in the ED: To admit or discharge

1998 • 26 citations

High yield of chest radiography in walk-in clinic patients with chest symptoms

1993 • 24 citations

Spatial pattern of cdc2 expression in relation to meristem activity and cell proliferation during plant development

1992 • 17 citations

Assessment of Breathlessness

1989 • 17 citations

A novel and highly divergent Arabidopsis cyclin isolated by complementation in budding yeast

2001 • 16 citations

Negative regulatory elements of the Saccharomyces cerevisiae PHO system: interaction between PHO80 and PHO85 proteins

1990 • 14 citations

Diagnosis

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The Arabidopsis Cks1At protein binds the cyclin-dependent kinases Cdc2aAt and Cdc2bAt

1997 • 10 citations

Protein sequences — homologies and motifs

1991 • 6 citations