E-cadherin and catenins: Molecules with versatile roles in normal and neoplastic epithelial cell biology

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

Expressed recombinant cadherins mediate cell sorting in model systems

1988 • 673 citations

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.

1995 • 651 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

Adhesion in cell migration

1995 • 520 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression

1991 • 501 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

1997 • 494 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

β-Catenin mutations in cell lines established from human colorectal cancers

1997 • 483 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.

1993 • 434 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway.

1994 • 420 citations

Solution Structure of the Epithelial Cadherin Domain Responsible for Selective Cell Adhesion

1995 • 414 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Signal transduction by β-catenin

1995 • 398 citations

The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.

1992 • 385 citations

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

1991 • 364 citations

Molecular linkage between cadherins and actin filaments in cell—cell adherens junctions

1992 • 359 citations

Expression of E- and P-cadherin in gastric carcinomas.

1991 • 345 citations

Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein

1995 • 342 citations

Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness.

1992 • 337 citations

Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes

1996 • 337 citations

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

1994 • 326 citations

Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus.

1996 • 322 citations

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

1995 • 304 citations

E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.

1993 • 297 citations

Adhesion molecules during somitogenesis in the avian embryo.

1987 • 293 citations

The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules

1993 • 291 citations

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.

1994 • 284 citations

E-cadherin mediated adhesion system in cancer cells

1996 • 281 citations

Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.

1992 • 280 citations

Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.

1991 • 272 citations

Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin

1997 • 260 citations

E-cadherin and alpha-catenin expression in human esophageal cancer.

1994 • 253 citations

Catenins as mediators of the cytoplasmic functions of cadherins

1993 • 249 citations

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.

1993 • 249 citations

The EGF receptor is an actin-binding protein.

1992 • 248 citations

Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival

1997 • 243 citations

Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro.

1990 • 229 citations

Aberrant E-cadherin and alpha-catenin expression in prostate cancer: correlation with patient survival.

1997 • 228 citations

A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis

1993 • 226 citations

Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39

1995 • 225 citations

Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1)

1995 • 225 citations

Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.

1997 • 225 citations

NH2-terminal Deletion of β-Catenin Results in Stable Colocalization of Mutant β-Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion

1997 • 220 citations

Classical cadherins

1992 • 217 citations

Oxford Textbook of Pathology

1994 • 210 citations

Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin)

1991 • 208 citations

Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.

1993 • 205 citations

Beta-catenin expression in human cancers.

1996 • 202 citations

Cell adhesion and signal transduction: the Armadillo connection

1995 • 200 citations

Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor.

1992 • 190 citations

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

1996 • 186 citations

Specific interaction of vinculin with α-actinin

1987 • 185 citations

Submembranous junctional plaque proteins include potential tumor suppressor molecules.

1993 • 179 citations

Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries

1995 • 178 citations

Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant

1994 • 176 citations

Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients.

1996 • 174 citations

APC in the regulation of intestinal crypt fission

1998 • 168 citations

Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin.

1995 • 166 citations

c-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells

1994 • 162 citations

Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps.

1997 • 161 citations

Intestinal trefoil factor controls the expression of the adenomatous polyposis coli–catenin and the E-cadherin–catenin complexes in human colon carcinoma cells

1998 • 151 citations

Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture.

1995 • 138 citations

Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line

1995 • 138 citations

Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer

1992 • 137 citations

Altered expression and function of E‐cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma

1995 • 133 citations

Rapid epithelial restitution of human and rabbit colonic mucosa

1989 • 113 citations

Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer

1994 • 112 citations

Immunohistochemical detection of alpha-catenin expression in human cancers.

1994 • 110 citations

The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis

1993 • 109 citations

Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells

1992 • 105 citations

Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid

1992 • 87 citations

Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel

1995 • 85 citations

Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.

1996 • 83 citations

Poorly Differentiated Colon Carcinoma Cell Lines Deficient in α-Catenin Expression Express High Levels of Surface E-cadherin but Lack Ca²⁺-Dependent Cell-Cell Adhesion

1993 • 80 citations

E-cadherin transfection down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes.

1996 • 76 citations

Differential perturbations in the morphogenesis of anterior structures induced by overexpression of truncated XB- and N-cadherins in Xenopus embryos.

1994 • 65 citations

The molecular histology of neoplasia: the role of the cadherin/catenin complex

1997 • 65 citations

The molecular basis for the assembly and modulation of adherens-type junctions

1990 • 62 citations

N-cadherin-associated proteins in chicken muscle

1991 • 54 citations

L‐Cam expression in normal, premalignant, and malignant colon mucosa

1992 • 52 citations

DIFFERENTIAL EXPRESSION OF E-CADHERIN IN NORMAL, METAPLASTIC AND DYSPLASTIC ESOPHAGEAL MUCOSA - A PUTATIVE BIOMARKER

1994 • 50 citations

Ovarian transposition in young patients with invasive cervical cancer receiving radiation therapy

1994 • 40 citations

Role of the E-cadherin/α-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells

1995 • 37 citations

Immunohistochemical Analysis of E-Cadherin Expression in Human Colorectal Tumours

1993 • 37 citations

L‐CAM expression in lymph node and liver metastases of colorectal carcinomas

1994 • 34 citations

Expression and potential role of E-cadherin in pancreatic carcinoma

1996 • 31 citations

Epithelial restitution in the large intestine of the rat following insult with bile salts

1988 • 31 citations

RELATIONSHIP BETWEEN E-CADHERIN EXPRESSION AND LYMPH-NODE METASTASIS IN HUMAN ESOPHAGEAL CANCER

1994 • 25 citations

TGF‐α can act as morphogen and/or mitogen in a colon‐cancer cell line

1994 • 24 citations

Ultrastructural features of rectal epithelium of the mouse during the early phases of migration to repair a defect

1986 • 23 citations

Inhibition of growth and enhancement of differentiation of colorectal carcinoma cell lines by MAb MR6 and IL-4

1997 • 19 citations

Walter and Israel General Pathology

1996 • 12 citations

Lectins: from basic science to clinical application in cancer prevention

1998 • 12 citations

Deleted Work

1955 • 0 citations