Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1994 • 406 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma

1992 • 229 citations

Complexes of polyoma virus medium T antigen and cellular proteins.

1985 • 223 citations

Cell adhesion and signal transduction: the Armadillo connection

1995 • 200 citations

Mutations in the APC gene and their implications for protein structure and function

1995 • 188 citations

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

1996 • 186 citations

Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries

1995 • 178 citations

Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli

1994 • 125 citations