Physiology and Pathophysiology of GLP-1

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

1993 • 1,579 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

1993 • 1,064 citations

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

1992 • 912 citations

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

1967 • 908 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans

1994 • 868 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

1987 • 830 citations

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

1987 • 814 citations

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1993 • 814 citations

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

1987 • 773 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

1995 • 741 citations

The incretin concept today

1979 • 730 citations

NEW INTERPRETATION OF ORAL GLUCOSE TOLERANCE

1964 • 693 citations

Glucagon-like peptide-1(7–36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns

1993 • 678 citations

Truncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man

1993 • 661 citations

Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man

1992 • 620 citations

Hamster preproglucagon contains the sequence of glucagon and two related peptides

1983 • 602 citations

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

1993 • 576 citations

Glucagon-Like Peptide-1 and Glucose-Dependent Insulin-Releasing Polypeptide Plasma Levels in Response to Nutrients

1995 • 572 citations

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

1987 • 566 citations

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

1993 • 533 citations

Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide

1995 • 519 citations

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations.

1993 • 467 citations

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

1996 • 460 citations

Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites

1995 • 451 citations

Tissue‐specific expression of the human receptor for glucagon‐like peptide‐I: brain, heart and pancreatic forms have the same deduced amino acid sequences

1995 • 425 citations

Gastric emptying and release of incretin hormones after glucose ingestion in humans.

1996 • 416 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Effect of Truncated Glucagon-Like Peptide-1 [Proglucagon-(78–107) amide] on Endocrine Secretion from Pig Pancreas, Antrum, and Nonantral Stomach

1988 • 391 citations

Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

1988 • 389 citations

Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.

1991 • 371 citations

Entero-Insular Axis

1969 • 366 citations

Distribution of glucagonlike peptide I (GLP‐I), glucagon, and glicentin in the rat brain: An immunocytochemical study

1988 • 325 citations

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.

1992 • 323 citations

Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse.

1994 • 321 citations

Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets.

1993 • 321 citations

Biological Effects and Metabolic Rates of Glucagonlike Peptide-1 7–36 Amide and Glucagonlike Peptide-1 7–37 in Healthy Subjects Are Indistinguishable

1993 • 311 citations

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7–37) in normal and diabetic subjects

1994 • 309 citations

Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose

1968 • 294 citations

Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal.

1994 • 283 citations

Insulinotropic Action of Glucagonlike Peptide-I-(7–37) in Diabetic and Nondiabetic Subjects

1992 • 282 citations

New developments in the incretin concept

1985 • 275 citations

Structure-activity studies of glucagon-like peptide-1.

1994 • 272 citations

Gut Peptides

1994 • 268 citations

Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop.

1993 • 264 citations

Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

1989 • 254 citations

On the treatment of Diabetus mellitus by acid extract of Duodenal Mucous Membrane

1906 • 253 citations

Regulation of immunoreactive-insulin release from a rat cell line (RINm5F)

1983 • 240 citations

Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7–36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides

1995 • 221 citations

Ileal release of glucagon-like peptide-1 (GLP-1)

1995 • 216 citations

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

1993 • 214 citations

Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon.

1984 • 206 citations

Pancreatic and intestinal processing of proglucagon in man

1987 • 203 citations

Complete Sequences of Glucagon-like Peptide-1 from Human and Pig Small Intestine

1989 • 201 citations

Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man

1994 • 187 citations

Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7–36) amide, on fatty acid synthesis in explants of rat adipose tissue

1991 • 186 citations

Coexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut

1984 • 183 citations

Gut hormones and diabetes mellitus

1992 • 182 citations

Reduction of the Incretin Effect in Rats by the Glucagon-Like Peptide 1 Receptor Antagonist Exendin (9–39) Amide

1995 • 180 citations

Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats

1994 • 179 citations

GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans

1989 • 176 citations

Proglucagon processing in porcine and human pancreas.

1994 • 167 citations

Identification and Localization of Glucagon-Like Peptide-1 and Its Receptor in Rat Brain*

1987 • 166 citations

Cellular localization of proglucagon/glucagon‐like peptide I messenger RNAs in rat brain

1986 • 165 citations

Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic a cells

1988 • 161 citations

Peptide amidation

1991 • 159 citations

2 Intra-islet insulin—glucagon—somatostatin relationships

1986 • 158 citations

Regulation of Intestinal Proglucagon- Derived Peptide Secretion by Intestinal Regulatory Peptides*

1991 • 156 citations

Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy

1991 • 154 citations

Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.

1990 • 154 citations

Receptors for glucagon-like peptide-1(7–36) amide on rat insulinoma-derived cells

1988 • 153 citations

Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor

1993 • 150 citations

Gastric Inhibitory Polypeptide

1982 • 149 citations

Pre-Proglucagon Messenger Ribonucleic Acid: Nucleotide and Encoded Amino Acid Sequences of the Rat Pancreatic Complementary Deoxyribonucleic Acid*

1984 • 147 citations

The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).

1993 • 146 citations

GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery

1993 • 143 citations

Glucagon‐like peptide 1: A potent glycogenic hormone

1994 • 133 citations

Potent glycogenic effect of GLP-1(7?36)amide in rat skeletal muscle

1994 • 133 citations

Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.

1989 • 131 citations

Glucagon-Like Peptide-1 7-36 Amide and Peptide YY from the L-Cell of the Ileal Mucosa Are Potent Inhibitors of Vagally Induced Gastric Acid Secretion in Man

1994 • 128 citations

Voglibose (AO-128) Is an Efficient α-Glucosidase Inhibitor and Mobilizes the Endogenous GLP-1 Reserve

1995 • 125 citations

Signal transduction crosstalk in the endocrine system: pancreatic β-cells and the glucose competence concept

1992 • 125 citations

Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides

1995 • 124 citations

Enteral Enhancement of Glucose Disposition by Both Insulin-Dependent and Insulin-Independent Processes: A Physiological Role of Glucagon-Like Peptide I

1995 • 120 citations

Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity.

1993 • 117 citations

The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization

1994 • 114 citations

Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase

1984 • 111 citations

Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption

1983 • 110 citations

Identification and characterization of glucagon‐like peptide‐1 7–36 amide‐binding sites in the rat brain and lung

1988 • 110 citations

Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells

1994 • 109 citations

Comparison of the Effects of Various C-Terminal and NTerminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas*

1989 • 109 citations

Functional characterization of a cAMP-responsive element of the rat insulin I gene.

1990 • 107 citations

Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3′,5′-Monophosphate Formation*

1990 • 106 citations

Glucagon-like peptide-1-(7-36) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line.

1993 • 104 citations

Structure of Glucagon-Like Peptide(7-36) Amide in a Dodecylphosphocholine Micelle as Determined by 2D NMR

1994 • 102 citations

Functional receptors for the insulinotropic hormone glucagon‐like peptide‐I(7–37) on a somatostatin secreting cell line

1991 • 98 citations

Cholinergic Agonists Prime the β-Cell to Glucose Stimulation

1989 • 95 citations

Structure/Activity Characterization of Glucagon‐Like Peptide‐1

1994 • 94 citations

Influence of Gastric Inhibitory Polypeptide Antiserum on Glucose-Induced Insulin Secretion in Rats

1982 • 91 citations

Gut Peptides: Biochemistry and Physiology

1994 • 90 citations

Glucagon‐like peptide‐1(7–36) amide is a new incretin/enterogastrone candidate

1991 • 89 citations

Glucagon-like peptide-1 (7–36)-NH2: a physiological inhibitor of gastric acid secretion in man

1990 • 89 citations

Modulation of Glucose-Induced Insulin Secretion from a Rat Clonal β-Cell Line*

1990 • 88 citations

Cosecretion of amylin and insulin from isolated rat pancreas

1990 • 88 citations

Adaptation of muscle to creatine depletion: effect on GLUT-4 glucose transporter expression

1993 • 88 citations

Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue.

1993 • 86 citations

Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain

1992 • 86 citations

Lipolytic action of glucagon-like peptides in isolated rat adipocytes

1992 • 86 citations

Nutrient-independent increases in proglucagon and ornithine decarboxylase messenger RNAs after jejunoileal resection

1992 • 85 citations

Stable expression of the rat GLP-I receptor in CHO cells: Activation and binding characteristics utilizing GLP-I(7–36)-amide, oxyntomodulin, exendin-4, and exendin(9–39)

1994 • 85 citations

Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7–36) amide on the rat pancreas

1993 • 84 citations

Ca2+ and pancreatic B-cell function

1994 • 83 citations

Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line.

1994 • 78 citations

Cyclic AMP as a determinant for glucose induction of fast Ca2+ oscillations in isolated pancreatic beta-cells

1991 • 75 citations

Homologous Desensitization of the Insulinotropic Glucagon-Like Peptide-I(7–37) Receptor on Insulinoma (HIT-T15) Cells*

1991 • 74 citations

Glucagon-like peptide-1 binding to rat skeletal muscle

1995 • 72 citations

Effect of glucagon-like peptide-1 on insulin secretion

1988 • 70 citations

Gastric Inhibitory Polypeptide (GIP) and Insulin Release after Small-Bowel Resection in Man

1980 • 70 citations

Hypersecretion of Truncated Glucagon‐like Peptide‐1 and Gastric Inhibitory Polypeptide in Obese Patients

1993 • 69 citations

Colchicine-induced redistribution of an apical membrane glycoprotein (gp330) in proximal tubules

1989 • 69 citations

Human Glucagon-Like Peptide-1 Receptor Gene: Localization to Chromosome Band 6p21 by Fluorescence In Situ Hybridization and Linkage of a Highly Polymorphic Simple Tandem Repeat DNA Polymorphism to Other Markers on Chromosome 6

1993 • 68 citations

Characterization of high‐affinity receptors for truncated glucagon‐like peptide‐1 in rat gastric glands

1990 • 67 citations

Ileal proglucagon gene expression in the rat: Characterization in intestinal adaptation using in situ hybridization

1993 • 66 citations

Glucagon-like peptide-1(7–37)/(7–36)amide is a new incretin

1992 • 65 citations

The Effects of Glucagon-like Peptide-I (GLP-I) on Hormone Secretion from Isolated Human Pancreatic Islets

1995 • 65 citations

Effects of Glucagonlike Peptide l-(7–36) on Release of Insulin, Glucagon, and Somatostatin by Rat Pancreatic Islet Cell Monolayer Cultures

1989 • 65 citations

Cloning and Functional Expression of a Human Glucagon-like Peptide-1 Receptor

1993 • 64 citations

Physiological augmentation of amino acid-induced insulin secretion by GIP and GLP-I but not by CCK-8

1995 • 64 citations

Secretion of Glucagon-Like Peptide-1 and Reactive Hypoglycemia after Partial Gastrectomy

1994 • 61 citations

Identification of Specific Binding Sites for Glucagon-Like Peptide-1 on the Posterior Lobe of the Rat Pituitary

1995 • 60 citations

Synergistic stimulatory effect of glucagon‐like peptide‐1 (7–36) amide and glucose‐dependent insulin‐releasing polypeptide on the endocrine rat pancreas

1989 • 58 citations

Signal transduction of the GLP‐1‐receptor cloned from a human insulinoma

1994 • 58 citations

Absence of insulinotropic glucagon‐like peptide‐I(7–37) receptors on isolated rat liver hepatocytes

1991 • 57 citations

Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7–36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells

1993 • 57 citations

Failure of GLP-l(7–36)amide to affect glycogenesis in rat skeletal muscle

1995 • 57 citations

Signal transmission after GLP-1(7-36)amide binding in RINm5F cells

1989 • 56 citations

Effect of Glucagon-Like Peptide-1 on Gastric Somatostatin and Gastrin Secretion in the Rat

1990 • 55 citations

Lack of Effect of Synthetic Human Gastric Inhibitory Polypeptide and Glucagon-LikePeptide 1 [7-36 Amide] Infused at Near-Physiological Concentrations on Pentagastrin-Stimulated Gastric Acid Secretion in Normal Human Subjects

1992 • 53 citations

Isolation and characterisation of GLP‐1 7–36 amide from rat intestine Elevated levels in diabetic rats

1988 • 52 citations

Characterization of the receptor for glucagon-like peptide-1(7–36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking

1989 • 52 citations

Rat parietal cell receptors for GLP-1-(7-36) amide: northern blot, cross-linking, and radioligand binding

1994 • 52 citations

Molecular Forms of Glucagon-Like Peptide-1 in Human Pancreas and Glucagonomas

1985 • 51 citations

Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.

1995 • 50 citations

Molecular cloning of a cDNA encoding for the GLP-1 receptor expressed in rat lung

2009 • 50 citations

Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation

1993 • 46 citations

Glucagon-like Peptide-1 Modulates Ca2+ Current But Not K+ATP Current in Intact Mouse Pancreatic B-Cells

1995 • 46 citations

Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells.

1995 • 45 citations

Structural Characterization by Affinity Cross‐Linking of Glucagon‐Like Peptide‐1(7–36)Amide Receptor in Rat Brain

1995 • 45 citations

Differences in glucagon-like peptide-1 and GIP responses following sucrose ingestion

1992 • 45 citations

Selective release of glutamine and glutamic acid produced by perfusion of GLP-1(7–36) amide in the basal ganglia of the conscious rat

1992 • 44 citations

Effect of truncated glucagon‐like peptide 1 on cAMP in rat gastric glands and HGT‐1 human gastric cancer cells

1988 • 43 citations

Characterization of receptors for glucagon‐like peptide‐1(7–36) amide on rat lung membranes

1990 • 43 citations

Glucagon and Related Peptides in Fetal Rat Hypothalamusin Vivoandin Vitro*

1990 • 43 citations

Postprandial Release of Glucagon-Like Peptide-1, Pancreatic Glucagon, and Insulin after Esophageal Resection

1993 • 41 citations

Truncated glucagon‐like peptide‐1 (proglucagon 78–107 amide), an intestinal insulin‐releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)

1988 • 41 citations

Effect of Intestinal Inhibitory Peptides on Vagally Induced Secretion from Isolated Perfused Porcine Pancreas

1993 • 40 citations

Priming effect of glucagon-like peptide-1 (7–36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas

1991 • 40 citations

Fate of Pancreatic Enzymes in the Human Intestinal Lumen in Health and Pancreatic Insufficiency

1993 • 39 citations

Glucagon-like peptide-1 does not have a role in hepatic carbohydrate metabolism

1985 • 39 citations

Structure–activity relationships of glucagon-like peptide-1(7–36)amide: insulinotropic activities in perfused rat pancreases, and receptor binding and cyclic AMP production in RINm5F cells

1994 • 38 citations

Reduced Insulinotropic Effects of Glucagonlike Peptide I-(7–36)-Amide and Gastric Inhibitory Polypeptide in Isolated Perfused Diabetic Rat Pancreas

1990 • 38 citations

Glycosylation of the GLP-1 receptor is a prerequisite for regular receptor function

1994 • 37 citations

Characterization of glucagon‐like peptide‐I(7–36)amide receptors of rat lung membranes by covalent cross‐linking

1991 • 37 citations

Depression of Insulin Release by Anti-GIP Serum after Oral Glucose in Rats

1981 • 35 citations

Tissue-Specific Differences in the Levels of Proglucagon-Derived Peptides in Streptozotocin-Induced Diabetes*

1989 • 34 citations

Human Glucagon-Like Peptide-1 Receptor Gene in NIDDM: Identification and Use of Simple Sequence Repeat Polymorphisms in Genetic Analysis

1994 • 34 citations

CORRELATION OF THE 24-HOUR RADIOIODINE UPTAKE OF THE HUMAN THYROID GLAND WITH THE SIX- AND EIGHT-HOUR UPTAKES AND THE “ACCUMULATION GRADIENT”

1951 • 33 citations

Glucagon-like peptide-1(7–36)amide: characterization of the domain responsible for binding to its receptor on rat insulinoma RINm5F cells

1990 • 33 citations

Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.

1992 • 33 citations

Solubilization of active GLP‐1 (7–36)amide receptors from RINm5F plasma membranes

1992 • 33 citations

Interaction of Glucagon-Like Peptide- 1 (7–36)amide and Somatostatin-14 in RINm5F Cells and in the Perfused Rat Pancreas

1989 • 32 citations

Early O-glycosidic glycosylation of proglucagon in pancreatic islets: an unusual type of prohormonal modification.

1986 • 32 citations

Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells.

1994 • 32 citations

Influence of glucagon-like peptide-1 on β cell responsiveness

1993 • 31 citations

Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas.

1990 • 31 citations

Glucose sensing of individual pancreatic β-cells involves transitions between steady-state and oscillatory cytoplasmic Ca2+

1992 • 29 citations

Effects of glucagon like-1(7–36)amide on the ctoplasmic Ca2+-concentration in rat islet cells

1993 • 29 citations

Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young

1994 • 29 citations

Glucose-dependent alterations of intracellular free calcium by glucagon-like peptide-1(7-36amide) in individual obob mouse β-cells

1994 • 29 citations

Secretion of an insulinotropic factor from isolated, perfused rat intestine.

1979 • 28 citations

Expression of ileal glucagon and peptide tyrosine-tyrosine genes. Response to inhibition of polyamine synthesis in the presence of massive small-bowel resection

1992 • 26 citations

Somatostatin and Epinephrine Decrease Insulin Messenger Ribonucleic Acid in HIT Cells through a Pertussis Toxin-Sensitive Mechanism*

1991 • 24 citations

Distribution and chemical phenotypes of neuroendocrine cells in the human anal canal

1994 • 24 citations

Glucagon-like peptide: a therapeutic glimmer

1994 • 23 citations

Rat gastric somatostatin and gastrin release: Interactions of exendin-4 and truncated glucagon-like peptide-1 (GLP-1) amide

1994 • 22 citations

Pituitary adenylate cyclase-activating polypeptide receptors of types I and II and glucagon-like peptide-I receptors are expressed in the rat medullary carcinoma of the thyroid cell line 6/23.

1994 • 22 citations

Glucagonlike peptide-1 (7–36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured in-R1-G9 cells

1992 • 22 citations

Detection of the Human Glucagon-Like Peptide 1(7-36) Amide Receptor on Insulinoma-Derived Cell Membranes

1994 • 22 citations

Alterations of plasma immunoreactive glucagon-like peptide-1 behavior in non-insulin-dependent diabetics

1990 • 21 citations

Interactions between cholinergic agonists and enteric factors in the regulation of insulin secretion from isolated perifused rat islets

1989 • 21 citations

Identification of Glucagon-Like Peptide-1(7–36) Amide in Rat Brain

1989 • 20 citations

Functional characterization of somatostatin receptors expressed on hamster glucagonoma cells

1995 • 19 citations

Glucagon-like immunoreactivity in hypothalamic neurons of the rat

1990 • 18 citations

EFFECT OF GLUCAGON-LIKE PEPTIDE-1 AND -2 ON GLYCOGENOLYSIS IN CULTURED RAT HEPATOCYTES

1986 • 18 citations

Effects of Glucagon-Like Peptide 1 (7-36) Amide and Glucagon on Amylin Release from Perfused Rat Pancreas

1991 • 18 citations

Glucagon-Like Peptide-1(7-37) does not Stimulate either Hepatic Glycogenolysis or Ketogenesis.

1990 • 17 citations

Solubilization of active receptors for glucagon-like peptide-1(7-36)amide from rat lung membranes

1993 • 16 citations

Cisapride Stimulates Human Esophageal Motility

1995 • 16 citations

Dexamethasone pretreatment of rat insulinoma cells decreases binding of glucagon-like peptide-1(7–36)amide

1990 • 15 citations

Glucagon-like peptide 1 immunoreactivity in gastroentero-pancreatic endocrine tumors: a light- and electron-microscopic study

1994 • 15 citations

Interaction of glucagon-like peptide-I (7–37) and somatostatin-14 on signal transduction and proinsulin gene expression in βTC-1 cells

1994 • 13 citations

Molecular and Functional Characterization of Insulin Receptors Present on Hamster Glucagonoma Cells

1994 • 12 citations

Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas.

1990 • 11 citations

Internalization of glucagon-like peptide-1(7–36)amide in rat insulinoma cells

1989 • 11 citations

Enteroglucagon release in disaccharide malabsorption induced by intestinal alpha-glucosidase inhibition.

1989 • 11 citations

グルカゴン様ペプチド‐1(7‐37)は,肝のグリコーゲン分解もケトン体生成もどちらも刺激しない

1990 • 10 citations

FIVE pS ANION CHANNELS IN HUMAN AIRWAY EPITHELIAL CELLS

1992 • 10 citations

Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide

1993 • 10 citations

[Human glucagon-like peptide-1 receptor gene in NIDDM].

1994 • 9 citations

Effect of proglucagon-derived peptides on amylase release from rat pancreatic acini

1990 • 8 citations

Glucagon-Like Peptide 1: On Its Way to Clinical Application

1993 • 8 citations

Isolation and characterization of GLP-1 7–36 amide from rat intestine

1989 • 7 citations

The Glucagon Gene Is Transcribed in β-like Pancreatic Cells

1995 • 6 citations

Diabetes

1993 • 2 citations

Deleted Work

1955 • 0 citations

Cited By (0)

Loading...