Is there a balance between microglia and astrocytes in regulating Th1/Th2-cell responses and neuropathologies?

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

1998 • 275 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

IL-12 production by central nervous system microglia is inhibited by astrocytes.

1997 • 263 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

Dialogue between the CNS and the immune system in lymphoid organs

1998 • 159 citations

IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells.

1997 • 153 citations

Indictment of the microglia as the villain in multiple sclerosis

1997 • 148 citations

T-cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture

1995 • 143 citations

Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis

1997 • 137 citations

Immune regulation within the central nervous system

1998 • 126 citations

Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion

1998 • 109 citations

Astrocytic Factors Deactivate Antigen Presenting Cells that Invade the Central Nervous System

1998 • 94 citations

Astrocytes protect neurons from neurotoxic injury by serum glutamate

1998 • 89 citations

CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.

1999 • 86 citations

Microglial phagocytosis is modulated by pro-and anti-inflammatory cytokines

1997 • 72 citations

Astrocytes promote process outgrowth by adult human oligodendrocytes in vitro through interaction between bFGF and astrocyte extracellular matrix

1996 • 70 citations

CD40-CD154 Interaction and IFN-γ Are Required for IL-12 But Not Prostaglandin E2 Secretion by Microglia During Antigen Presentation to Th1 Cells

1999 • 67 citations

Transforming growth factor-β1 induces apoptosis of rat microglia without relation to bcl-2 oncoprotein expression

1997 • 55 citations

Interaction between apoptotic cells and reactive brain cells in the central nervous system of rats with autoimmune encephalomyelitis

1998 • 38 citations

Astrocytes induce hyporesponses of myelin basic protein-reactive T and B cell function

1998 • 35 citations

Modulation of T cell-endothelial adhesion by astrocyte conditioned medium.

1997 • 12 citations

Modulation of T cell-endothelial adhesion by astrocyte conditioned medium

1997 • 11 citations

Nerve growth factor prevents inflammation and demyelination in a non human model of multiple sclerosis

1998 • 3 citations