Endogenous interleukin‐6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

1996 • 1,498 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Cytokine signal transduction

1994 • 1,358 citations

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.

1969 • 1,011 citations

Messenger plasticity in primary sensory neurons following axotomy and its functional implications

1994 • 743 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor

1997 • 622 citations

Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons

1995 • 622 citations

Primary afferent tachykinins are required to experience moderate to intense pain

1998 • 587 citations

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons

1996 • 583 citations

Defective inflammatory response in interleukin 6-deficient mice.

1994 • 540 citations

Peripheral and Central Mechanisms of NGF‐induced Hyperalgesia

1994 • 505 citations

Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain

1994 • 469 citations

The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo

1994 • 460 citations

The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule

1995 • 427 citations

Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons

1995 • 382 citations

Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons

1992 • 367 citations

Interleukin-6-Mediated Hyperalgesia/Allodynia and Increased Spinal IL-6 Expression in a Rat Mononeuropathy Model

1996 • 366 citations

Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice.

1996 • 346 citations

Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons

1995 • 298 citations

Central hyperexcitability triggered by noxious inputs

1993 • 290 citations

Impaired neuroglial activation in interleukin-6 deficient mice

1997 • 284 citations

Induction of interleukin-6 in axotomized sensory neurons

1995 • 273 citations

Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section

1985 • 268 citations

Interleukin‐6 Production by Schwann Cells and Induction in Sciatic Nerve Injury

1995 • 254 citations

The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study

1991 • 247 citations

Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons

1993 • 244 citations

Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy

1996 • 212 citations

Effects of intrathecal administration of neuropeptides on a spinal nociceptive reflex in the rat: VIP, galanin, CGRP, TRH, somatostatin and angiotensin II

1988 • 207 citations

Interleukin‐6 and Transforming Growth Factor‐β1 mRNAs are Induced in Rat Facial Nucleus Following Motoneuron Axotomy

1993 • 205 citations

N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint

1993 • 194 citations

Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human

1983 • 179 citations

Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain

1994 • 176 citations

Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice

1998 • 172 citations

Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG

1997 • 167 citations

Histochemical characterization of sensory neurons with high-affinity receptors for nerve growth factor

1989 • 165 citations

Up-regulation of leukaemia inhibitory factor and interleukin-6 in transected sciatic nerve and muscle following denervation

1996 • 160 citations

NOCICEPTIVE RESPONSES IN INTERLEUKIN-6-DEFICIENT MICE TO PERIPHERAL INFLAMMATION AND PERIPHERAL NERVE SECTION

1997 • 147 citations

Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord

1987 • 144 citations

Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation

1994 • 142 citations

Correlation between GAP43 and nerve growth factor receptors in rat sensory neurons

1990 • 140 citations

Interleukin 6 in Intact and Injured Mouse Peripheral Nerves

1996 • 139 citations

Influence of leukemia inhibitory factor on galanin/GMAP and neuropeptide Y expression in mouse primary sensory neurons after axotomy

1996 • 137 citations

Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats

1995 • 127 citations

Leukaemia Inhibitory Factor Induced in the Sciatic Nerve after Axotomy is Involved in the Induction of Galanin in Sensory Neurons

1996 • 124 citations

Influence of nerve growth factor on neurofilament gene expression in mature primary sensory neurons

1990 • 123 citations

The differential control of c-jun expression in regenerating sensory neurons and their associated glial cells

1994 • 122 citations

Differential expression of galanin immunoreactivities in the primary sensory neurons following partial and complete sciatic nerve injuries

1997 • 119 citations

Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.

1988 • 106 citations

Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones.

1995 • 106 citations

Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine

1998 • 97 citations

Intrathecal injections of galanin and its antiserum affect nociceptive response of rat to mechanical, but not thermal, stimuli

1991 • 86 citations

Interferon-γ receptors in nociceptive pathways

1997 • 83 citations

Intrathecal galanin at low doses increases spinal reflex excitability in rats more to thermal than mechanical stimuli

1988 • 78 citations

Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia

1996 • 77 citations

Responses to heat of C-fiber nociceptors in monkey are altered by injury in the receptive field but not by adjacent injury

1988 • 57 citations

Sprouting of A‐fibre primary afferents into lamina II in two rat models of neuropathic pain

1997 • 53 citations

Leukemia inhibitory factor induces sympathetic sprouting in intact dorsal root ganglia in the adult rat in vivo

1998 • 48 citations

GP130 cytokines, leukemia inhibitory factor and interleukin-6, induce neuropeptide expression in intact adult rat sensory neuronsin vivo: Time-course, specificity and comparison with sciatic nerve axotomy

1998 • 46 citations

Leukemia inhibitory factor induces mechanical allodynia but not thermal hyperalgesia in the juvenile rat

1996 • 40 citations

The effect of NGF, BDNF and bFGF on expression of galanin in cultured rat dorsal root ganglia

1997 • 40 citations

Isolation and characterization of biologically active murine interleukin-6 produced in Escherichia coli

1991 • 22 citations

Vector-Derived Expression of Recombinant Rat Interleukin-6

1996 • 8 citations

Isolation and characterization of biologically active murine interleukin-6 produced in Escherichia coli

1991 • 4 citations