The cell-cell channel in the control of growth

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Oncogenes and signal transduction

1991 • 2,816 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN

1925 • 1,630 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

1976 • 1,290 citations

Junctional intercellular communication: the cell-to-cell membrane channel.

1981 • 1,268 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

Junctional intercellular communication and the control of growth

1979 • 965 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

Cellular Biology and Biochemistry of the Retinoids

1984 • 730 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.

1990 • 697 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

PERMEABILITY OF MEMBRANE JUNCTIONS*

1966 • 654 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus

1981 • 591 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Elimination of Metabolic Cooperation in Chinese Hamster Cells by a Tumor Promoter

1979 • 559 citations

Connexin family of gap junction proteins

1990 • 553 citations

STUDIES ON AN EPITHELIAL (GLAND) CELL JUNCTION

1964 • 503 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

Tumor Suppressor Genes: The Puzzle and the Promise

1989 • 488 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

Morphoregulatory molecules

1988 • 460 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

Growth inhibition of transformed cells correlates with their junctional communication with normal cells

1986 • 416 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.

1986 • 374 citations

Two configurations of a channel-forming membrane protein

1984 • 368 citations

Transfection of C6 glioma cells with connexin 43 cDNA: analysis of expression, intercellular coupling, and cell proliferation.

1991 • 366 citations

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.

1991 • 366 citations

Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation

1990 • 358 citations

Phosphorylation of Connexin43 Gap Junction Protein in Uninfected and Rous Sarcoma Virus-Transformed Mammalian Fibroblasts

1990 • 352 citations

STUDIES ON THE MECHANISM OF ACTION OF A NEW Ca²⁺ ANTAGONIST, 8‐(N,N‐DIETHYLAMINO)OCTYL 3,4,5‐TRIMETHOXYBENZOATE HYDROCHLORIDE IN SMOOTH AND SKELETAL MUSCLES

1975 • 347 citations

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation

1984 • 333 citations

Permeability of cell junction depends on local cytoplasmic calcium activity

1975 • 328 citations

Positive selection of candidate tumor-suppressor genes by subtractive hybridization.

1991 • 320 citations

Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells

1979 • 315 citations

Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules.

1988 • 301 citations

Two homologous protein components of hepatic gap junctions

1987 • 284 citations

Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.

1990 • 276 citations

Permeability of the Cell-to-Cell Membrane Channels in Mammalian Cell Junction

1979 • 274 citations

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

1986 • 272 citations

Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori region

1982 • 257 citations

Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts

1984 • 232 citations

Intercellular Communication: Renal, Urinary Bladder, Sensory, and Salivary Gland Cells

1965 • 218 citations

Intercellular communication and tissue growth

1971 • 212 citations

Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

1985 • 210 citations

The cell-to-cell channel of gap junctions

1987 • 206 citations

Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth

1991 • 201 citations

The actions of retinoids on cellular growth correlate with their actions on gap junctional communication.

1989 • 184 citations

Transcription Control by Oncogenes

1985 • 176 citations

Oncogenes, ions, and phospholipids

1985 • 171 citations

Diameter of the Cell-to-Cell Junctional Membrane Channels as Probed with Neutral Molecules

1981 • 170 citations

The Cellular src Gene Product Regulates Junctional Cell-to-Cell Communication

1988 • 169 citations

Rapid and reversible reduction of junctional permeability in cells infected with a temperature-sensitive mutant of avian sarcoma virus.

1981 • 164 citations

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins.

1991 • 162 citations

On the genesis of cellular communication

1967 • 160 citations

Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation

1989 • 154 citations

INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

1967 • 151 citations

The Croonian Lecture, 1971 Cell fusion and the analysis of malignancy

1971 • 150 citations

Intercellular communication in normal and regenerating rat liver: a quantitative analysis.

1981 • 142 citations

Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32.

1990 • 142 citations

A study of communication specificity between cells in culture.

1977 • 137 citations

Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos.

1990 • 135 citations

Altered junctional permeability between cells transformed by v-ras, v-mos, or v-src

1988 • 128 citations

Neural differentiation, NCAM-mediated adhesion, and gap junctional communication in neuroectoderm. A study in vitro.

1988 • 126 citations

Growth factors modulate junctional cell-to-cell communication

1988 • 119 citations

Tumor promoters cause a rapid and reversible inhibition of the formation and maintenance of electrical cell coupling in culture.

1981 • 116 citations

Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester.

1985 • 115 citations

Diacylglycerol inhibits gap junctional communication in cultured epidermal cells: Evidence for a role of protein kinase C

1985 • 111 citations

Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle

1992 • 109 citations

Intercellular communication and the control of growth: X. Alteration of junctional permeability by thesrc gene. A study with temperature-sensitive mutant Rous sarcoma virus

1984 • 106 citations

Major loss of the 28-kD protein of gap junction in proliferating hepatocytes.

1987 • 105 citations

Transfer of growth inhibition between normal and virus-transformed cells: autoradiographic studies using marked cells

1967 • 104 citations

Selective lack of intercellular communication between transformed and nontransformed cells as a common property of chemical and oncogene transformation of BALB/c 3T3 cells.

1987 • 103 citations

Retinoid‐enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein

1990 • 101 citations

Mitogens and melittin stimulate an increase in intracellular free calcium concentration in human fibroblasts

1984 • 99 citations

The Membrane Junctions in Communicating and Noncommunicating Cells, Their Hybrids, and Segregants

1974 • 97 citations

Decreased incidence of gap junctions between Chinese hamster V-79 cells upon exposure to the tumor promoter 12--tetradecanoyl phorbol-13-acetate

1982 • 97 citations

Communication between Cells of Different Type

1971 • 93 citations

Potential role of the src gene product in inhibition of gap-junctional communication in NIH/3T3 cells.

1985 • 93 citations

Correction of cell–cell communication defect by introduction of a protein kinase into mutant cells

1983 • 92 citations

Intercellular Diffusion

1964 • 92 citations

Selective contact-dependent cell communication

1976 • 90 citations

Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-β and peptide hormones in normal human keratinocytes

1989 • 80 citations

Phorbol ester-mediated inhibition of intercellular communication in BALB/c 3T3 cells: relationship to enhancement of cell transformation.

1985 • 79 citations

Role of small t antigen in the acute transforming activity of SV40

1982 • 76 citations

Low-resistance Coupling between Gland Cells. Some Observations on Intercellular Contact Membranes and Intercellular Space

1964 • 69 citations

Density-dependent regulation of cell growth: An example of a cell-cell recognition phenomenon

1981 • 68 citations

Infection of rat liver epithelial cells with v‐Ha‐ras: Correlation between oncogene expression, gap junctional communication, and tumorigenicity

1990 • 67 citations

Polyomavirus Middle T Antigen Downregulates Junctional Cell-to-Cell Communication

1987 • 66 citations

Specific viral oncogenes cause differential effects on cell‐to‐cell communication, relevant to the suppression of the transformed phenotype by normal cells

1988 • 65 citations

Rapid inhibition of intercellular communication between BALB/c 3T3 cells by diacylglycerol, a possible endogenous functional analogue of phorbol esters.

1985 • 64 citations

Diacylglycerol downregulates junctional membrane permeability. TMB-8 blocks this effect

1985 • 63 citations

Retinol inhibition of ornithine decarboxylase induction and G1 progression in Chinese hamster ovary cells.

1979 • 62 citations

Rapid and reversible inhibition of junctional communication by tumor promoters in a mouse cell line.

1983 • 61 citations

Regulation of cell-to-cell communication by phosphorylation.

1985 • 56 citations

Interaction with normal cells suppresses the transformed phenotype of v-myc-transformed quail muscle cells

1989 • 56 citations

Monoclonal antibody ECCD-1 inhibits intercellular communication in teratocarcinoma PCC3 cells

1984 • 52 citations

Quantitative neoplastic transformation of C3H/10T1/2 fibroblasts: dependence upon the size of the initiated cell colony at confluence.

1983 • 49 citations

Polyomavirus middle T antigen downregulates junctional cell-to-cell communication.

1987 • 46 citations

Intercellular communication and tissue growth: VIII. A genetic analysis of junctional communication and cancerous growth

1977 • 45 citations

Retinoic acid inhibits junctional communication between animal cells

1986 • 43 citations

Differential regulation of communication by retinoic acid in homologous and heterologous junctions between normal and transformed cells.

1991 • 40 citations

Regulation of cell-to-cell communication by phosphorylation.

1985 • 40 citations

Potential role of the human Ha‐ras oncogene in the inhibition of gap junctional intercellular communication

1989 • 39 citations

The relevance of gap junctions to stage I tumor promotion in mouse epidermis

1984 • 37 citations

Similar and synergistic inhibition of gap-junctional communication by ras transformation and tumor promoter treatment of mouse primary keratinocytes.

1989 • 35 citations

Inhibition of gap-junctional intercellular communication between epithelial cells transformed by the activated H-ras-1 oncogene

1989 • 33 citations

Inhibition of electrical coupling in pairs of murine pancreatic acinar cells by OAG and isolated protein kinase C

1989 • 32 citations

Requirements for and kinetics of growth arrest of neoplastic cells by confluent 10T1/2 fibroblasts induced by a specific inhibitor of cyclic adenosine 3':5'-phosphodiesterase.

1985 • 29 citations

Properties of a hybrid between lines sensitive and insensitive to contact inhibition of cell division

1968 • 28 citations

Effects of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate on junctional communication in intact mouse skin: persistance of homologous communication and increase of epidermal – dermal coupling

1988 • 28 citations

A simian virus 40 dl884/tsA58 double mutant is temperature sensitive for abortive transformation

1983 • 27 citations

Transformation of NIH 3T3 cells by cotransfection with c-src and nuclear oncogenes.

1987 • 26 citations

Intercellular communication and the control of growth: XI. Alteration of junctional permeability by thesrc gene in a revertant cell with normal cytoskeleton

1984 • 25 citations

Intercellular communication and the control of growth: XII. Alteration of junctional permeability by simian virus 40. roles of the large and smallT antigens

1984 • 24 citations

Downregulation of cell-to-cell communication by the viralsrc gene is blocked by TMB-8 and recovery of communication is blocked by vanadate

1986 • 23 citations

Limiting factors of the V79 cell metabolic cooperation assay for tumor promoters

1983 • 23 citations

The effect of phorbols on metabolic cooperation between human fibroblasts

1982 • 23 citations

Transfer of information through cell junctions and growth control.

1969 • 21 citations

Action of TMB-8 (8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate) on cytoplasmic free calcium in adrenal glomerulosa cell

1986 • 20 citations

Junctional intercellular communication is cooperatively inhibited by oncogenes in transformation.

1989 • 19 citations

The action of v-src on gap junctional permeability is modulated by pH.

1990 • 19 citations

Retinoic acid blocks junctional communication between animal cells

1981 • 18 citations

Regulation of Intercellular Communication and Growth by the Cellular src Gene ^a

1988 • 14 citations

Inhibition of protein kinase C activation by 8-(N,N-diethylamino)-octyl-3, 4, 5-trimethoxybenzoate (TMB-8), an intracellular Ca2+ antagonist.

1985 • 8 citations