Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Dysregulation of Apoptosis in Cancer

1999 • 983 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Mitochondrion as a Novel Target of Anticancer Chemotherapy

2000 • 536 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Cell biological mechanisms of multidrug resistance in tumors.

1994 • 377 citations

The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2.

1995 • 293 citations

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

1995 • 258 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

Apoptosis of Lung Cancer Cells Caused by Some Anti-cancer Agents (MMC, CPT-11, ADM) is Inhibited by BCL-2

1993 • 168 citations

Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.

1993 • 166 citations

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 • 146 citations

Bcl‐2 overexpression enhances the metastatic potential of a human breast cancer line

1997 • 142 citations

Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

1993 • 109 citations

Partial Inhibition of Multidrug Resistance by Safingol Is Independent of Modulation of P-glycoprotein Substrate Activities and Correlated with Inhibition of Protein Kinase C

1995 • 98 citations

Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2.

2001 • 90 citations

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1992 • 85 citations

Bcl-2 overexpression results in reciprocal downregulation of Bcl-XL and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis

1999 • 79 citations

Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes α and θ

2001 • 67 citations

Flavopiridol circumvents Bcl‐2 family mediated inhibition of apoptosis and drug resistance in B‐cell chronic lymphocytic leukaemia

2001 • 64 citations

Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

1996 • 60 citations

Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoptosis of human melanoma cells

2001 • 57 citations

Down-regulation of apoptosis-related bcl-2 but not bcl-xL or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells

1996 • 51 citations

Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells.

1996 • 39 citations

bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant mcf7 cells

1999 • 34 citations

Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells.

1996 • 34 citations

N‐Acetylcysteine Modifies cis‐Dichlorodiammineplatinum‐induced Effects in Bladder Cancer Cells

1999 • 32 citations

Temozolomide reduces the metastatic potential of lewis lung carcinoma (3LL) in mice: Role of α-6 integrin phosphorylation

1995 • 22 citations

Inhibition of protein kinase C in multidrug-resistant cells by modulators of multidrug resistance

1997 • 18 citations

Bcl‐2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity

2001 • 15 citations

Characterization and modulation of drug transport kinetics in K562 cl.6 daunorubicin‐resistant cell line

1994 • 10 citations