HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death

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1998 • 5,359 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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Features of apoptotic cells measured by flow cytometry

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

2000 • 1,170 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1998 • 496 citations

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

1998 • 494 citations

Phase I Clinical and Pharmacokinetic Study of Bcl-2 Antisense Oligonucleotide Therapy in Patients With Non-Hodgkin’s Lymphoma

2000 • 460 citations

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

2001 • 445 citations

Mechanisms of apoptosis avoidance in cancer

1999 • 371 citations

Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening

2001 • 312 citations

Apoptosis Triggered by Myc-Induced Suppression of Bcl-X_L or Bcl-2 Is Bypassed during Lymphomagenesis

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Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model.

1994 • 187 citations

Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer.

2002 • 165 citations

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

1999 • 153 citations

Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: Correlation with 3q27 and 18q21 chromosomal abnormalities

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Glucocorticoids and rituximab in vitro: synergistic direct antiproliferative and apoptotic effects

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Bcl-XL protects cancer cells from p53-mediated apoptosis.

1995 • 126 citations

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

2002 • 121 citations

Measurement of Spontaneous and Therapeutic Agent-Induced Apoptosis With BCL-2 Protein Expression in Acute Myeloid Leukemia

1997 • 112 citations

Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.

2002 • 99 citations

The Chemical Biology of Apoptosis

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Apoptosis and the response to anticancer therapy

2001 • 90 citations

Bcl‐2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins

1999 • 85 citations

In vitro expansion of hematopoietic progenitor cells induces functional expression of Fas antigen (CD95)

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The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195.

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Expression of Apoptosis-Controlling Proteins in Acute Leukemia Cells

1999 • 48 citations

Clinical studies of antisense therapy in cancer

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Controlling the mitochondrial gatekeeper for effective chemotherapy

2000 • 12 citations

Clinical studies of antisense therapy in cancer

2000 • 10 citations