Animal models of inflammatory bowel disease

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

1990 • 2,321 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

Experimental models of inflammatory bowel disease

1995 • 1,215 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

Endoscopic and histological healing with infliximab anti–tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial

1999 • 755 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Colorectal cancer prevention in ulcerative colitis: a case‐control study

2000 • 580 citations

Oxazolone Colitis: A Murine Model of T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4

1998 • 523 citations

1,25-Dihydroxycholecalciferol Prevents and Ameliorates Symptoms of Experimental Murine Inflammatory Bowel Disease

2000 • 499 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease

1998 • 393 citations

Experimental Production of Diffuse Colitis in Rats

1978 • 339 citations

Different Subsets of Enteric Bacteria Induce and Perpetuate Experimental Colitis in Rats and Mice

2001 • 334 citations

Citrobacter rodentiumInfection in Mice Elicits a Mucosal Th1 Cytokine Response and Lesions Similar to Those in Murine Inflammatory Bowel Disease

1999 • 279 citations

Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain

1998 • 273 citations

A comparative analysis of two models of colitis in rats

1992 • 265 citations

Therapeutic effect of intracolonically administered nuclear factorκB (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis

2000 • 261 citations

Regulation of Murine Intestinal Inflammation by Reactive Metabolites of Oxygen and Nitrogen

2001 • 245 citations

XII. IL-10-deficient (IL-10^−/−) mice and intestinal inflammation

2000 • 227 citations

TNF-αneutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis

2003 • 194 citations

Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice.

2002 • 178 citations

Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens.

1999 • 178 citations

VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice

2000 • 177 citations

Specific type IV phosphodiesterase inhibitor rolipram mitigates experimental colitis in mice.

2000 • 158 citations

Green Tea Polyphenol Extract Attenuates Inflammation in Interleukin-2–Deficient Mice, a Model of Autoimmunity

2001 • 158 citations

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis

2003 • 154 citations

Colitis in transgenic and knockout animals as models of human inflammatory bowel disease

1999 • 151 citations

Cutting Edge: Chronic Intestinal Inflammation in STAT-4 Transgenic Mice: Characterization of Disease and Adoptive Transfer by TNF- Plus IFN-γ-Producing CD4+ T Cells That Respond to Bacterial Antigens

1999 • 143 citations

Autoimmune Intestinal Pathology Induced by hsp60-Specific CD8 T Cells

1999 • 136 citations

Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis

2000 • 136 citations

Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats

1999 • 134 citations

Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1.

2000 • 133 citations

Acetyl-11-keto-β-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis

2001 • 129 citations

Treatment of T Cell-Dependent Experimental Colitis in SCID Mice by Local Administration of an Adenovirus Expressing IL-18 Antisense mRNA

2002 • 128 citations

Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells

1998 • 115 citations

Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.

2003 • 108 citations

Animal models of inflammatory bowel disease

2002 • 108 citations

CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice

1997 • 107 citations

Down-Regulation of Intestinal Lymphocyte Activation and Th1 Cytokine Production by Antibiotic Therapy in a Murine Model of Crohn’s Disease

2002 • 92 citations

Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine

2002 • 91 citations

Dextran sulfate sodium-induced murine colitis activates NF-κB and increases galanin-1 receptor expression

2000 • 86 citations

Novel antioxidants zolimid and AEOL11201 ameliorate colitis in rats.

2001 • 78 citations

Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury

1988 • 76 citations

Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis

2003 • 74 citations

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

2002 • 74 citations

Treatment of experimental colitis by oral tolerance induction: a central role for suppressor lymphocytes

2000 • 65 citations

Involvement of CD4+ T Cells in the Development of Dextran Sulfate Sodium-Induced Experimental Colitis and Suppressive Effect of IgG on Their Action

1998 • 59 citations

The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis

2000 • 59 citations

Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.

2001 • 49 citations

New Ulcerative Colitis Model Induced by Sulfhydryl Blockers in Rats and the Effects of Antiinflammatory Drugs on the Colitis.

1997 • 45 citations

Effects of Trimetazidine on Acetic Acid-Induced Colitis in Female Swiss Rats

2003 • 45 citations

The Specific Type-4 Phosphodiesterase Inhibitor Mesopram Alleviates Experimental Colitis in Mice

2003 • 39 citations

Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.

2001 • 39 citations

Anorexia in a rat model of colitis: interaction of interleukin-1 and hypothalamic serotonin

2002 • 38 citations

The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7.

1997 • 37 citations

Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis

2003 • 31 citations

Effect of Heparin on Tissue Binding Activity of Fibroblast Growth Factor and Heparin-Binding Epidermal Growth Factor in Experimental Colitis in Rats

2002 • 28 citations

Role of Commensal Bacteria in Chronic Experimental Colitis: Lessons from the HLA-B27 Transgenic Rat

2002 • 27 citations

Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis

2002 • 26 citations

Effect of L-arginine on the course of experimental colitis

2001 • 26 citations

Murine monoclonal anti-tNF antibody administration has a beneficial effect on inflammatory bowel disease that develops in IL-10 knockout mice.

2002 • 24 citations

Therapeutic effects of an oral adsorbent on acute dextran sulphate sodium-induced colitis and its recovery phase in rats, especially effects of elimination of bile acids in gut lumen

2000 • 16 citations

Mucosal T cells as a target for treatment of IBD.

2003 • 15 citations

Interleukin-2-Deficient Mice Develop Colitis in the Absence of CD28 Costimulation

2002 • 13 citations

The majority of lamina propria CD4+ T-cells from scid mice with colitis undergo Fas-mediated apoptosis in vivo

2001 • 11 citations

Sulphydryl Blocker-Induced Rat Colitis Is Ameliorated by Intravenous Injection of Antibody to Colonic Surfactant-Like Particle

1999 • 10 citations

Sulphydryl blocker-induced rat colitis is ameliorated by intravenous injection of antibody to colonic surfactant-like particle

2007 • 4 citations