Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

1990 • 2,321 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Ulcerative Colitis and Colorectal Cancer

1990 • 1,755 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Experimental models of inflammatory bowel disease

1995 • 1,215 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders

1990 • 1,001 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Colorectal cancer prevention in ulcerative colitis: a case‐control study

2000 • 580 citations

Folate and carcinogenesis: evidence, mechanisms, and implications

1999 • 566 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.

2000 • 475 citations

APC gene: database of germline and somatic mutations in human tumors and cell lines

1996 • 428 citations

Mutations in the p53 gene: An early marker of neoplastic progression in ulcerative colitis

1994 • 420 citations

Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

1995 • 416 citations

Risk factors for colorectal cancer in patients with ulcerative colitis: A case-control study

1994 • 343 citations

The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis

1997 • 300 citations

Neoplastic progression in ulcerative colitis: Histology, DNA content, and loss of a p53 allele

1992 • 280 citations

Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis.

1996 • 273 citations

Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice.

2000 • 241 citations

Promotion of colorectal neoplasia in experimental murine ulcerative colitis.

1996 • 231 citations

p53 Point mutations in dysplastic and cancerous ulcerative colitis lesions

1993 • 231 citations

DNA mismatch repair and cancer

1995 • 178 citations

Genomic Instability Is an Early Event during the Progression Pathway of Ulcerative-Colitis-Related Neoplasia

1999 • 177 citations

Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms.

1995 • 176 citations

Molecular genetic profiles of colitis-associated neoplasms

1994 • 168 citations

Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.

1992 • 159 citations

C-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma

1990 • 150 citations

Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers.

1994 • 146 citations

Evidence that CD4⁺, but not CD8⁺ T cells are responsible for murine interleukin‐2‐deficient colitis

1995 • 144 citations

Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model

1996 • 142 citations

p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma

1994 • 138 citations

Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias

1995 • 138 citations

K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.

1994 • 110 citations

Activation of c-Ki-ras in human gastrointestinal dysplasias determined by direct sequencing of polymerase chain reaction products.

1990 • 100 citations

Comparative analysis of histology, DNA content,p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis

1998 • 100 citations

INFLAMMATORY BOWEL DISEASE AND CANCER

1997 • 99 citations

SomaticApc mutations are selected upon their capacity to inactivate the ?-catenin downregulating activity

2000 • 95 citations

Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development

2001 • 94 citations

A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis

1995 • 91 citations

c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis

1991 • 88 citations

Lens epithelial cells derived from αB‐crystallin knockout mice demonstrate hyperproliferation and genomic instability

2001 • 70 citations

Molecular Genetics of Colorectal Cancer

1995 • 66 citations

Microsatellite instability and K- mutations in patients with ulcerative colitis

2000 • 61 citations

Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats

1998 • 58 citations

Histochemical study of colonic cancer in experimental colitis of rats

1993 • 58 citations

c-Ki-ras mutations in dysplastic fields and cancers in ulcerative colitis

1992 • 56 citations

Tumor-associated Apc mutations in Mlh1−/−Apc1638N mice reveal a mutational signature of Mlh1 deficiency

2000 • 42 citations

High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease.

1995 • 33 citations

Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.

1999 • 26 citations

The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer *

1999 • 26 citations

No involvement of Ki‐ras or p53 gene mutations in colitis‐associated rat colon tumors induced by 1‐hydroxyanthraquinone and methylazoxymethanol acetate

1995 • 23 citations

No involvement ofAPC gene mutations in ulcerative colitis–associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate

1997 • 18 citations

Polyploidization induced by acridine orange in mouse osteosarcoma cells.

2000 • 12 citations