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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

A simple method for organotypic cultures of nervous tissue

1991 • 3,075 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

1992 • 617 citations

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1993 • 546 citations

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

1993 • 489 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Rapid Communication: Characterization of β‐Amyloid Peptide from Human Cerebrospinal Fluid

1993 • 383 citations

An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

1997 • 368 citations

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

1989 • 353 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

1994 • 317 citations

Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells

1996 • 308 citations

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

1992 • 231 citations

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

1994 • 214 citations

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 202 citations

The neuropathology of Alzheimer's disease: A review with pathogenetic, aetiological and therapeutic considerations

1985 • 199 citations

Age-Dependent Neuronal and Synaptic Degeneration in Mice Transgenic for the C Terminus of the Amyloid Precursor Protein

1996 • 197 citations

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease

1995 • 183 citations

Regional synaptic pathology in Alzheimer's disease

1992 • 176 citations

APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain

1994 • 166 citations

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

1997 • 164 citations

Long‐term hippocampal slices: A model system for investigating synaptic mechanisms and pathologic processes

1995 • 154 citations

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.

1993 • 152 citations

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

1997 • 135 citations

Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.

1995 • 130 citations

Enhanced Release of Amyloid -Protein from Codon 670/671 Swedish Mutant -Amyloid Precursor Protein Occurs in Both Secretory and Endocytic Pathways

1996 • 129 citations

Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells

1995 • 126 citations

Evidence for lysosomal processing of amyloid ?-protein precursor in cultured cells

1989 • 114 citations

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1–42, in differentiated PC12 cells

1997 • 110 citations

The Unique Nature of the Serine Interactions for α1-Adrenergic Receptor Agonist Binding and Activation

1996 • 103 citations

Quantitative Assessment of Synaptic Density in the Outer Molecular Layer of the Hippocampal Dentate Gyrus in Alzheimer's Disease

1996 • 97 citations

Stable maintenance of glutamate receptors and other synaptic components in long‐term hippocampal slices

1995 • 89 citations

Chloroquine inhibits intracellular segradation but not decretion of Alzheimerβ/A4 amyloid precursor protein.

1992 • 80 citations

Induction of β-Amyloid-Containing Polypeptides in Hippocampus: Evidence for a Concomitant Loss of Synaptic Proteins and Interactions with an Excitotoxin

1994 • 72 citations

Abnormal tau species are produced during Alzheimer's disease neurodegenerating process

1989 • 67 citations

Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia

1984 • 65 citations

Lamina‐specific synaptic connections of hippocampal neurons in vitro

1995 • 47 citations

β-amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin

1994 • 29 citations

Age-Related Phosphorylation and Fragmentation Events Influence the Distribution Profiles of Distinct Tau Isoforms in Mouse Brain

1998 • 22 citations

Discoveries and Inventions of the Nineteenth Century

1875 • 4 citations