Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

1993 • 809 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine

1984 • 689 citations

The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

1995 • 559 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

The Golgi complex: In vitro veritas?

1992 • 481 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

1989 • 437 citations

Neurofilaments are obligate heteropolymers in vivo

1993 • 387 citations

Research advances in Alzheimer's disease and related disorders

1995 • 230 citations

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1991 • 210 citations

Characterization of Sorting Signals in the β-Amyloid Precursor Protein Cytoplasmic Domain

1995 • 194 citations

A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein.

1991 • 185 citations

Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells.

1991 • 178 citations

Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein

1994 • 175 citations

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.

1993 • 152 citations

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

1992 • 147 citations

The Alzheimer β-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

1993 • 141 citations

Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11.

1993 • 137 citations

Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.

1995 • 130 citations

Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway

1992 • 103 citations

Altered cleavage and secretion of a recombinant β–APP bearing the Swedish familial Alzheimer's disease mutation

1994 • 90 citations

Basolateral Secretion of Amyloid Precursor Protein in Madin-Darby Canine Kidney Cells Is Disturbed by Alterations of Intracellular pH and by Introducing a Mutation Associated with Familial Alzheimer's Disease

1995 • 64 citations

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

1995 • 62 citations

Metabolism of the “Swedish” amyloid precursor protein variant in Madin-Darby canine kidney cells.

1994 • 51 citations

Mutant and native human β-amyloid precursor proteins in transgenic mouse brain

1995 • 39 citations

Response : Delivery of Na ⁺ ,K ⁺ -ATPase in Polarized Epithelial Cells

1993 • 18 citations