New perspectives into the biological and clinical relevance of oestrogen receptors in the human breast

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 • 1,680 citations

Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells

2004 • 1,360 citations

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

2001 • 1,179 citations

Mechanisms of Tamoxifen Resistance: Increased Estrogen Receptor-HER2/neu Cross-Talk in ER/HER2-Positive Breast Cancer

2004 • 1,134 citations

Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse

1997 • 968 citations

Estrogen receptor pathways to AP-1

2000 • 867 citations

Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

1978 • 797 citations

Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

2003 • 716 citations

Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells

1977 • 686 citations

Dissociation between steroid receptor expression and cell proliferation in the human breast.

1997 • 623 citations

Human Estrogen Receptor -Gene Structure, Chromosomal Localization, and Expression Pattern

1997 • 576 citations

Nature of Functional Estrogen Receptors at the Plasma Membrane

2006 • 518 citations

The Complete Primary Structure of Human Estrogen Receptor β (hERβ) and Its Heterodimerization with ER αin Vivoandin Vitro

1998 • 510 citations

Cloning and Characterization of Human Estrogen Receptor β Isoforms

1998 • 508 citations

Estrogen Receptor (ER)-β Reduces ERα-Regulated Gene Transcription, Supporting a “Ying Yang” Relationship between ERα and ERβ in Mice

2003 • 476 citations

Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors.

2001 • 476 citations

Estrogen receptor phosphorylation

2002 • 468 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Estrogen Receptor–Positive, Progesterone Receptor–Negative Breast Cancer: Association With Growth Factor Receptor Expression and Tamoxifen Resistance

2005 • 459 citations

Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human

1998 • 452 citations

Steroid hormone receptors in breast cancer management

1998 • 445 citations

AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to the Estrogen Receptor

2000 • 438 citations

Transcriptional activation of genes by 17β-estradiol through estrogen receptor-Sp1 interactions

2001 • 414 citations

Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements

2000 • 393 citations

Prognostic significance of progesterone receptor levels in estrogen receptor-positive patients with metastatic breast cancer treated with tamoxifen: results of a prospective Southwest Oncology Group study.

1992 • 360 citations

Distribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression

2006 • 357 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor

1997 • 326 citations

A putative human breast stem cell population is enriched for steroid receptor-positive cells

2004 • 319 citations

Identification of a Structural Determinant Necessary for the Localization and Function of Estrogen Receptor α at the Plasma Membrane

2003 • 317 citations

Nuclear Receptor Minireview Series

2001 • 308 citations

Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer.

1995 • 297 citations

Invited Review: Cell localization, physiology, and nongenomic actions of estrogen receptors

2001 • 296 citations

Breast cancer, stem/progenitor cells and the estrogen receptor

2004 • 293 citations

Estrogen Receptor-Positive Proliferating Cells in the Normal and Precancerous Breast

1999 • 277 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

1995 • 273 citations

Enhanced Epidermal Growth Factor Receptor Signaling in MCF7 Breast Cancer Cells after Long-Term Culture in the Presence of the Pure Antiestrogen ICI 182,780 (Faslodex)*

2001 • 253 citations

Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer?

1999 • 244 citations

Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients.

1999 • 240 citations

Localization of the Estrogen Receptor Locus (ESR) to Chromosome 6q25.1 by FISH and a Simple Post-FISH Banding Technique

1993 • 229 citations

Estrogen receptors and proliferation markers in primary and recurrent breast cancer

2001 • 216 citations

Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-Free Survival Rates

2004 • 211 citations

Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer

2005 • 207 citations

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer

2004 • 207 citations

Reduced expression of oestrogen receptor β in invasive breast cancer and its re‐expression using DNA methyl transferase inhibitors in a cell line model

2003 • 200 citations

Oestrogen receptor expression in the normal and pre-cancerous breast

1999 • 199 citations

Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu.

2001 • 193 citations

Diversity in the mechanisms of gene regulation by estrogen receptors

2002 • 193 citations

Low Levels of Estrogen Receptor β Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer

2004 • 188 citations

Estrogen receptor beta expression in invasive breast cancer

2001 • 183 citations

Declining Estrogen Receptor-β Expression Defines Malignant Progression of Human Breast Neoplasia

2003 • 175 citations

Estrogen Induces Vascular Wall Dilation

2005 • 171 citations

Distinct steady–state nuclear receptor coregulator complexes exist in vivo

1998 • 165 citations

Expression of estrogen receptor β isoforms in normal breast epithelial cells and breast cancer: regulation by methylation

2003 • 162 citations

Estrogen Receptor β (ERβ) Level but Not Its ERβcx Variant Helps to Predict Tamoxifen Resistance in Breast Cancer

2004 • 158 citations

Expression of estrogen receptor beta1, beta2, and beta5 messenger RNAs in human breast tissue.

1999 • 149 citations

Distinct expression patterns of ER and ER in normal human mammary gland

2002 • 147 citations

Evaluation of seven oestrogen receptor β antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue

2002 • 138 citations

Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast

1991 • 133 citations

Estrogen receptor corepressors -- a role in human breast cancer?

2003 • 130 citations

Quantitative analysis of estrogen receptor-? mRNA and its variants in human breast cancers

2000 • 127 citations

Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor.

2002 • 126 citations

Influence of menstrual cycle, parity and oral contraceptive use on steroid hormone receptors in normal breast

1992 • 126 citations

Linkage of Rapid Estrogen Action to MAPK Activation by ER -Shc Association and Shc Pathway Activation

2002 • 119 citations

Nonendocrine Pathways and Endocrine Resistance

2004 • 118 citations

Evaluation of oestrogen receptor β wild-type and variant protein expression, and relationship with clinicopathological factors in breast cancers

2002 • 112 citations

Estrogen Modulation of Prolactin Gene Expression Requires an Intact Mitogen-Activated Protein Kinase Signal Transduction Pathway in Cultured Rat Pituitary Cells

2000 • 110 citations

Activation of Transcription by Estrogen Receptor α and β Is Cell Type- and Promoter-dependent

1999 • 106 citations

Oestrogen receptors alpha and beta differ in normal human breast and breast carcinomas

2002 • 105 citations

Phosphorylation of ERα at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERα phosphorylation in breast cancer progression

2006 • 98 citations

Multiple progesterone receptor assays in human breast cancer.

1984 • 92 citations

Differential Regulation of Estrogen Receptor (ER)α and ERβ in Primate Mammary Gland

2005 • 82 citations

Methylation of estrogen receptor β promoter correlates with loss of ER-β expression in mammary carcinoma and is an early indication marker in premalignant lesions

2005 • 79 citations

Membrane receptors for steroid hormones: Signal transduction and physiological significance

2002 • 77 citations

Phospho-Serine-118 Estrogen Receptor-α Expression Is Associated with Better Disease Outcome in Women Treated with Tamoxifen

2004 • 72 citations

Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promoters

1993 • 71 citations

Inducible upregulation of oestrogen receptor-β1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells

2005 • 68 citations

Endocrinology and hormone therapy in breast cancer: New insight into estrogen receptor-α function and its implication for endocrine therapy resistance in breast cancer

2005 • 66 citations

The Expression of ERβcx in Human Breast Cancer and the Relationship to Endocrine Therapy and Survival

2004 • 62 citations

Increased Estrogen Receptor βcx Expression during Mammary Carcinogenesis

2005 • 59 citations

Assessment of multiple different estrogen receptor-β antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions

2006 • 58 citations

A Multi-Centre Investigation Towards Reaching a Consensus on the Immunohistochemical Detection of ERβ in Archival Formalin-fixed Paraffin Embedded Human Breast Tissue

2005 • 49 citations

Expression of the estrogen receptor gene in developing and adult human breast

1996 • 44 citations

Growth factor signalling and response to endocrine therapy: the Royal Marsden Experience

2005 • 41 citations

Targeting estrogen responsive elements (EREs): design of potent transactivators for ERE-containing genes

2004 • 36 citations

Prognostic Significance of Estrogen Receptor Beta in Epithelial Hyperplasia of Usual Type With Known Outcome

2005 • 36 citations

Prospective evaluation of estrogen receptor-β in predicting response to neoadjuvant antiestrogen therapy in elderly breast cancer patients

2004 • 27 citations

Immunohistochemical evaluation of biological markers in mammary carcinoma in situ: correlation with morphological features and recently proposed schemes for histological classification

1996 • 25 citations

Identification of Wild-Type and Exon 5 Deletion Variants of Estrogen Receptor in Normal Human Mammary Gland

2000 • 17 citations

Oestrogen receptor, epidermal growth factor receptor and oncoprotein expression in non-involved tissue of cancerous breasts

1992 • 12 citations

Potential of endogenous estrogen receptor β to influence the selective ER modulator ERβ complex

2005 • 7 citations