Role of Aberrant Nitric Oxide Synthase‐3 Expression in Cerebrovascular Degeneration and Vascular‐mediated Injury in Alzheimer's Disease

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

1997 • 1,509 citations

NO at work

1994 • 1,493 citations

A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia

1997 • 973 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics

1983 • 758 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

1994 • 658 citations

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group

1997 • 612 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells

1995 • 484 citations

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

1996 • 413 citations

Proof of Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia

1996 • 377 citations

Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory epithelium

1994 • 375 citations

Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.

1995 • 337 citations

Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis

1997 • 337 citations

Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide

1993 • 327 citations

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

1997 • 300 citations

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.

1996 • 285 citations

Hippocampal sclerosis: a common pathological feature of dementia in very old (≥80 years of age) humans

1994 • 277 citations

Why are stroke patients prone to develop dementia?

1997 • 255 citations

Bax Protein Expression Is Increased in Alzheimerʼs Brain

1997 • 241 citations

Cerebral Infarction in Alzheimer's Disease Is Associated With Severe Amyloid Angiopathy and Hypertension

1995 • 226 citations

The Effects of Additional Pathology on the Cognitive Deficit in Alzheimer Disease

1997 • 220 citations

P53- and CD95-associated apoptosis in neurodegenerative diseases.

1998 • 196 citations

Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury

1996 • 192 citations

Alterations of the Blood-Brain Barrier and Glial Cells in White-Matter Lesions in Cerebrovascular and Alzheimer's Disease Patients

1996 • 189 citations

Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury

1994 • 184 citations

Multicenter clinicopathological correlation in dementia

1995 • 182 citations

Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion

1995 • 175 citations

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

1993 • 174 citations

Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism

1996 • 171 citations

Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP

1998 • 163 citations

Pathological markers associated with normal aging and dementia in the elderly

1993 • 162 citations

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

1994 • 159 citations

Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: A hypothesis for calcium-dependent and calcium-independent events activated by flow

1995 • 158 citations

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity

1997 • 147 citations

Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability

1999 • 147 citations

Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons.

1994 • 138 citations

Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability

1996 • 133 citations

Effect of nitric oxide synthase inhibition on cerebral blood flow and injury volume during focal ischemia in cats.

1993 • 127 citations

Relaxin Activates the <scp>l</scp> -Arginine–Nitric Oxide Pathway in Vascular Smooth Muscle Cells in Culture

1998 • 121 citations

Cyclic-GMP-Binding, Cyclic-GMP-Specific Phosphodiesterase (PDE5) Gene Expression Is Regulated during Rat Pulmonary Development

1998 • 120 citations

Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide

1993 • 119 citations

Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter changes

1998 • 117 citations

Impaired brain microcirculation may trigger Alzheimer's disease

1994 • 112 citations

Regressive changes of astroglia in white matter lesions in cerebrovascular disease and Alzheimer's disease patients

1997 • 111 citations

Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors

1996 • 100 citations

Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase

1993 • 99 citations

Decreased neuronal nitric oxide synthase messenger RNA and somatostatin messenger RNA in the striatum of Huntington's disease

1996 • 97 citations

Neuropathological Diagnoses in Elderly Patients in Oslo: Alzheimers Disease, Lewy Body Disease, Vascular Lesions

1995 • 78 citations

Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease

1998 • 75 citations

The nitric oxide synthase inhibitor, N-monomethyl-L-arginine blocks induction of a long-term potentiation-like phenomenon in rat medial frontal cortical neurons in vitro

1993 • 65 citations

Misery Perfusion with Preserved Vascular Reactivity in Alzheimer's Disease

1997 • 55 citations

Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease

1997 • 48 citations

Serum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects.

1992 • 46 citations

Amyloid β‐Protein Induces the Cerebrovascular Cellular Pathology of Alzheimer's Disease and Related Disordersa

1996 • 45 citations

Neuritic sprouting with aberrant expression of the nitric oxide synthase III gene in neurodegenerative diseases

1999 • 43 citations

Glutamate agonist-induced hippocampal lesion and nitric oxide synthase/NADPH-diaphorase: A light and electron microscopical study in the rat

1993 • 42 citations

Computed Tomography in the Detection of the Vascular Component in Dementia

1995 • 42 citations

[Effectiveness of brief infusions with Ginkgo biloba Special Extract EGb 761 in dementia of the vascular and Alzheimer type].

1996 • 39 citations

Neuronal Damage following Intraspinal Injection of a Nitric Oxide Synthase Inhibitor in the Rat

1996 • 39 citations

Dorsal root ganglion neurons of embryonic chicks contain nitric oxide synthase and respond to nitric oxide

1994 • 33 citations

Leukb-Araiosis and Cerebral Hypoperfusion Compared in Elderly Normals and Alzheimer's Dementia

1992 • 32 citations

[Free radicals and neural cell damage].

1994 • 26 citations

Histochemistry of Guanylate Cyclase, Phosphodiesterase, and NADPH-Diaphorase (Nitric Oxide Synthase) in Rat Brain Vasculature

1992 • 22 citations

In vivo vascular damage, leukocyte activation and inflammatory response induced by beta-amyloid.

1997 • 20 citations

The O-2A Lineage: From Rats to Humans

1994 • 6 citations

[Ginkgo biloba special extract EGb 761--an anti-dementia drug].

1998 • 5 citations

A Case of Alzheimer’s Disease with Extensive Focal White Matter Changes

1995 • 3 citations