The O-2A Lineage: From Rats to Humans

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture

1992 • 1,205 citations

Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types

1993 • 997 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics

1983 • 758 citations

A role for platelet-derived growth factor in normal gliogenesis in the central nervous system

1988 • 756 citations

Glial Cell Diversification in the Rat Optic Nerve

1989 • 725 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

1990 • 573 citations

Specific Expression of N‐Acetylaspartate in Neurons, Oligodendrocyte‐Type‐2 Astrocyte Progenitors, and Immature Oligodendrocytes In Vitro

1992 • 504 citations

Identification of an adult-specific glial progenitor cell

1989 • 476 citations

Evidence for migration of oligodendrocyte–type-2 astrocyte progenitor cells into the developing rat optic nerve

1987 • 471 citations

Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions

1986 • 456 citations

Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells

1993 • 441 citations

PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model

1991 • 410 citations

Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve I. Cell proliferation

1976 • 364 citations

PDGF A-chain gene is expressed by mammalian neurons during development and in maturity

1991 • 360 citations

Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell.

1984 • 336 citations

A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineages

1985 • 316 citations

Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. II. Time of origin

1976 • 315 citations

Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiation

1985 • 296 citations

Two proliferative stages of the oligodendrocyte lineage (A2B5+O4- and O4+GaIC-) under different mitogenic control

1990 • 270 citations

PDGF A chain homodimers drive proliferation of bipotential (O-2A) glial progenitor cells in the developing rat optic nerve.

1989 • 234 citations

Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells.

1992 • 230 citations

Fibroblast growth factor is a mitogen for oligodendrocytes in vitro

1985 • 227 citations

Characterization of cultured rat oligodendrocytes proliferating in a serum-free, chemically defined medium.

1985 • 205 citations

In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells.

1992 • 144 citations

Effects of neonatal transection on glial cell development in the rat optic nerve: evidence that the oligodendrocyte-type 2 astrocyte cell lineage depends on axons for its survival

1984 • 131 citations

In vivo analysis of glial cell phenotypes during a viral demyelinating disease in mice.

1989 • 121 citations

Division of astroblasts and oligodendroblasts in postnatal rodent brain: Evidence for separate astrocyte and oligodendrocyte lineages

1991 • 120 citations

Recovery after optic neuritis in childhood.

1988 • 111 citations

Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody.

1989 • 108 citations

Platelet‐derived growth factor is mitogenic for O‐2A^adult progenitor cells

1991 • 106 citations

Normal rat serum cytotoxicity against syngeneic oligodendrocytes

1989 • 102 citations

Coexistence of perinatal and adult forms of a glial progenitor cell during development of the rat optic nerve

1990 • 94 citations

Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury

1988 • 94 citations

A clonal analysis of glial lineages in neonatal forebrain development in vitro

1990 • 84 citations

The inhibition of oligodendrocytic differentiation of O‐2A progenitors caused by basic fibroblast growth factor is overridden by astrocytes

1993 • 72 citations

Points of controversy in the O‐2A lineage: Clocks and type‐2 astrocytes

1991 • 71 citations

The pathogenesis of demyelinating disease: insights from cell biology

1991 • 70 citations

Glial Cells in the Rat Optic Nerve

1991 • 55 citations

O‐2A glial progenitors from mature brain respond to CNS neuronal cell line‐derived growth factors

1991 • 55 citations

The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals

1992 • 51 citations

Elevation of acidic fibroblast growth factor mRNA in lesioned rat brain

1988 • 43 citations

Glial Cell Lineages in the Rat Optic Nerve

1983 • 36 citations

Postinjury Changes in Platelet‐Derived Growth Factor‐Like Activity in Fish and Rat Optic Nerves

1992 • 23 citations

The cellular measurement of time

1991 • 10 citations