Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

1989 • 912 citations

Spin trapping of superoxide and hydroxyl radical: Practical aspects

1980 • 861 citations

Spin trapping

1971 • 829 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Nitric oxide as a neuronal messenger

1991 • 638 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals

1988 • 507 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

1992 • 344 citations

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

1991 • 164 citations

Brain nitric oxide synthase is a haemoprotein

1992 • 151 citations

Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells

1987 • 146 citations

When are metal ion-dependent hydroxyl and alkoxyl radical adducts of 5,5-dimethyl-1-pyrroline N-oxide artifacts?

1992 • 117 citations

Endogenous Amino Acid Release from Cultured Cerebellar Neuronal Cells: Effect of Tetanus Toxin on Glutamate Release

1989 • 109 citations

Use of spin traps in biological systems

1985 • 102 citations

A Nitric Oxide Synthase Activity Selectively Stimulated by NMDA Receptors Depends on Protein Kinase C Activation in Mouse Striatal Neurons

1992 • 87 citations

Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus

1992 • 84 citations

Optimal EPR detection of weak nitroxide spin adduct and ascorbyl free radical signals

1992 • 53 citations

Antagonism by Ng-nitro-l-arginine ofl-glutamate-induced neurotoxicity in cultured neonatal rat cortical neurons. Prolonged application enhances neuroprotective efficacy

1993 • 49 citations

Atrial natriuretic peptide effects on cGMP and cAMP contents in microdissected glomeruli and segments of the rat and rabbit nephrons

1987 • 49 citations

Acute glutamate toxicity in cultured cerebellar granule cells: agonist potency, effects of pH, Zn2+ and the potentiation by serum albumin

1991 • 43 citations

Molecular characteristics and enzymology of nitric oxide synthase and soluble guanylyl cyclase in the CNS

1993 • 30 citations