Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch

Principles of CDK regulation

1995 • 3,267 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

p53-Independent Expression of p21 ^Cip1 in Muscle and Other Terminally Differentiating Cells

1995 • 1,058 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase

1995 • 404 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Reversal of Terminal Differentiation Mediated by p107 in Rb ^-/- Muscle Cells

1994 • 369 citations

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

1993 • 341 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

1994 • 289 citations

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 • 286 citations

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

1994 • 280 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

1989 • 248 citations

Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.

1993 • 233 citations

Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein

1993 • 220 citations

Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators.

1994 • 186 citations

Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubes.

1995 • 141 citations

Speculations on the roles of RB1 in tissue‐specific differentiation, tumor initiation, and tumor progression

1993 • 107 citations

MyoD induces retinoblastoma gene expression during myogenic differentiation.

1994 • 104 citations

Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells.

1994 • 102 citations

Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells.

1993 • 76 citations

Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile.

1995 • 46 citations