Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

2002 • 4,069 citations

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

2001 • 1,520 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

Proteasome inhibitors: from research tools to drug candidates

2001 • 1,159 citations

Activity-based protein profiling: The serine hydrolases

1999 • 1,054 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

2000 • 574 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

2000 • 564 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

Proteasome Inhibition Measurements: Clinical Application

2000 • 308 citations

A transgenic mouse model of the ubiquitin/proteasome system

2003 • 237 citations

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

2002 • 224 citations

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

1998 • 179 citations

Imaging 26S proteasome activity and inhibition in living mice

2003 • 177 citations

Chemistry in Living Cells: Detection of Active Proteasomes by a Two‐Step Labeling Strategy

2003 • 168 citations

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

2001 • 164 citations

Profiling the specific reactivity of the proteome with non-directed activity-based probes

2001 • 150 citations

Kinetic Characterization of the Chymotryptic Activity of the 20S Proteasome

1996 • 137 citations

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

2002 • 88 citations

Subtypes of 20S proteasomes from skeletal muscle

2001 • 77 citations

Recent Advances in the Identification and Development of 20S Proteasome Inhibitors

2002 • 25 citations

Assays for Proteasome Inhibition

2003 • 20 citations