Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Introduction of a rabbit β-globin gene into the mouse germ line

1981 • 458 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

QUANTITATIVE INVESTIGATIONS OF IDIOTYPIC ANTIBODIES

1972 • 291 citations

A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues

1983 • 245 citations

DNA Sequences Mediating Class Switching in α-Immunoglobulins

1980 • 243 citations

5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1980 • 238 citations

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

1980 • 213 citations

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

1978 • 211 citations

Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

1983 • 202 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

The role of gene deletion in the immunoglobulin heavy chain switch

1980 • 164 citations

Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes

1980 • 159 citations

The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse

1983 • 151 citations

Exon shuffling generates an immunoglobulin heavy chain gene.

1980 • 146 citations

Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.

1986 • 145 citations

Expression of lymphocyte surface IgE does not require switch recombination

1982 • 133 citations

Somatic hypermutation of an immunoglobulin transgene in K transgenic mice

1987 • 110 citations

The genetic basis of antibody production: The dominant anti‐arsonate idiotype response of the strain a mouse

1982 • 100 citations

Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.

1981 • 99 citations

Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype

1977 • 91 citations

Antibodies of the secondary response can be expressed without switch recombination in normal mouse B cells.

1984 • 88 citations

Suppression of idiotype and generation of suppressor T cells with idiotype-conjugated thymocytes.

1979 • 87 citations

Heterogeneity of an intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of A/J mice.

1980 • 81 citations

Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.

1987 • 74 citations

Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement.

1986 • 61 citations

Control of Immunoglobulin Class Switch Recombination

1986 • 60 citations

Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch.

1988 • 57 citations

Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate.

1983 • 45 citations

Unequal sister chromatid exchange. A mechanism affecting Ig gene arrangement and expression.

1985 • 40 citations

Recombinant Rabbit Secretory Immunoglobulin Molecules: Alpha Chains with Maternal (Paternal) Variable-Region Allotypes and Paternal (Maternal) Constant-Region Allotypes

1974 • 33 citations

Homologous chromosome recombination generating immunoglobulin allotype and isotype switch variants.

1986 • 32 citations

Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch

1985 • 22 citations

Relationship of VH and VL genes encoding three idiotypic families of anti-p-azobenzenearsonate antibodies.

1986 • 22 citations

Molecular analysis of heavy and light chains used by primary and secondary anti-(T,G)-A--L antibodies produced by normal and xid mice.

1987 • 16 citations